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Biomolecular condensates help organize the cell cytoplasm and nucleoplasm into spatial compartments with different chemical compositions. A key feature of such compositional patterning is the local enrichment of enzymatically active…

生物物理 · 物理学 2024-08-06 Andriy Goychuk , Leonardo Demarchi , Ivan Maryshev , Erwin Frey

The structural reorganization of the actin cytoskeleton is facilitated through the action of motor proteins that crosslink the actin filaments and transport them relative to each other. Here, we present a combined experimental-computational…

生物物理 · 物理学 2015-06-04 Daniel Gordon , Anne Bernheim-Groswasser , Chen Keasar , Oded Farago

The mechanosensitivity of cells, which determines how they are able to respond to mechanical signals received from their environment, is crucial for the functioning of all biological systems. In experiments, cells placed on cyclically…

生物物理 · 物理学 2019-01-17 John J. Molina , Ryoichi Yamamoto

This study investigates the three-dimensional organisation and evolution of stall cells in the separated flow region over an airfoil. Using a hybrid RANS/LES approach based on the DDES-SST turbulence model, we characterise the formation and…

流体动力学 · 物理学 2026-02-11 Rishabh Mishra , Emmanuel Guilmineau , Ingrid Neunaber , Caroline Braud

Internet, social media, neuronal or blood vessel are organized in complex networks. These networks are characterized by several quantities such as the underlying graph connectivity (topology), how they grow in time, scaling laws or by the…

亚细胞过程 · 定量生物学 2018-10-18 Matteo Dora , David Holcman

We present a theory for self-driven fluids, such as motorized cytoskeletal extracts or bacterial suspensions, that takes into account the underlying periodic duty cycle carried by the active particles of which the system is composed. We…

软凝聚态物质 · 物理学 2013-12-09 Sebastian Fürthauer , Sriram Ramaswamy

Viscous streaming is an efficient mechanism to exploit inertia at the microscale for flow control. While streaming from rigid features has been thoroughly investigated, when body compliance is involved, as in biological settings, little is…

流体动力学 · 物理学 2022-02-22 Yashraj Bhosale , Tejaswin Parthasarathy , Mattia Gazzola

Cell crawling crucially depends on the collective dynamics of the acto-myosin cytoskeleton. However, it remains an open question to what extent cell polarization and persistent motion depend on continuous regulatory mechanisms and…

生物物理 · 物理学 2023-08-11 Fenna Stegemerten , Karin John , Uwe Thiele

Blob-filaments (or simply 'blobs') are coherent structures formed by turbulence and sustained by nonlinear processes in the edge and scrape-off layer (SOL) of tokamaks and other magnetically confined plasmas. The dynamics of these…

等离子体物理 · 物理学 2023-07-26 J. R. Myra , J. Cheng , S. E. Parker

Channel formation and branching is widely seen in physical systems where movement of fluid through a porous structure causes the spatiotemporal evolution of the medium in response to the flow, in turn causing flow pathways to evolve. We…

Complex interactions between cellular systems and their surrounding extracellular matrices are emerging as important mechanical regulators of cell functions such as proliferation, motility, and cell death, and such cellular systems are…

软凝聚态物质 · 物理学 2021-04-16 Emmanuel L. C. VI M. Plan , Julia M. Yeomans , Amin Doostmohammadi

Viscous streaming is an efficient rectification mechanism to exploit flow inertia at small scales for fluid and particle manipulation. It typically entails a fluid vibrating around an immersed solid feature that, by concentrating stresses,…

流体动力学 · 物理学 2024-11-20 Songyuan Cui , Yashraj Bhosale , Mattia Gazzola

Viewed under a fluorescence microscope, the actomyosin cytoskeleton presents vivid streaks of lines together with persistent oscillatory waves. Using an active hydrodynamic approach, we show how a uniform distribution of single or mixture…

软凝聚态物质 · 物理学 2025-04-25 Ayan Roychowdhury , Saptarshi Dasgupta , Madan Rao

The cell cortex, a thin film of active material assembled below the cell membrane, plays a key role in cellular symmetry breaking processes such as cell polarity establishment and cell division. Here, we present a minimal model of the…

生物物理 · 物理学 2019-09-30 Alexander Mietke , V. Jemseena , K. Vijay Kumar , Ivo F. Sbalzarini , Frank Jülicher

How internal forces are transduced into motion through soft, fluid membranes remains a fundamental question in the study of active systems. To investigate this coupling, we develop a minimal system consisting of a single ferromagnetic…

软凝聚态物质 · 物理学 2025-07-11 Paula Magrinya , Arin Escobar Ortiz , Juan L. Aragones , Laura R. Arriaga

Active fluids operate by constantly dissipating energy at the particle level to perform a directed motion, yielding dynamics and phases without any equilibrium equivalent. The emerging behaviors have been studied extensively, yet…

统计力学 · 物理学 2020-02-03 Étienne Fodor , Takahiro Nemoto , Suriyanarayanan Vaikuntanathan

Activity can organize matter in unique configurations inaccessible to equilibrium systems, including a sundry of spiraling shapes seen in nature that range from galaxies to living tissues to fossilized stromatolites. How these dynamic yet…

软凝聚态物质 · 物理学 2023-05-23 Xingting Gong , Manu Prakash

Cell migration is a fundamental process underlying the survival and function of both unicellular and multicellular organisms. Crawling motility in eukaryotic cells arises from cyclic protrusion and retraction driven by the cytoskeleton,…

生物物理 · 物理学 2025-11-04 Blaž Ivšić , Igor Weber , Piotr Nowakowski , Ana-Sunčana Smith

Motor proteins drive persistent motion and self-organisation of cytoskeletal filaments. However, state-of-the-art microscopy techniques and continuum modelling approaches focus on large length and time scales. Here, we perform…

软凝聚态物质 · 物理学 2024-06-03 Gerrit Vliegenthart , Arvind Ravichandran , Marisol Ripoll , Thorsten Auth , Gerhard Gompper

Phase separation of multicomponent lipid membranes is characterized by the nucleation and coarsening of circular membrane domains that grow slowly in time as $\sim t^{1/3}$, following classical theories of coalescence and Ostwald ripening.…

软凝聚态物质 · 物理学 2023-08-01 Daniel P. Arnold , Aakanksha Gubbala , Sho C. Takatori