相关论文: In vitro evaluation of solution-based pressurised …
A challenge in pressurised metered-dose inhaler formulation design is management of adhesion of the drug to the canister wall, valve and actuator internal components and surfaces, especially for sedimenting or creaming suspensions. Visual…
Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug…
This study presents direct numerical simulation (DNS) of finite-size, interface-resolved ammonia and n-heptane droplets evaporating in decaying homogeneous isotropic turbulence. Simulations are conducted for each fuel to model the dynamics…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
In this paper, the self-assembly of condensed droplets on smooth and constrained surfaces under saturated vapor atmosphere of ethanol and methanol binary system is reported. Hexagonally ordered array of pores are obtained on smooth surfaces…
Reactor grade plasmas are likely to be fuelled by pellet injection. This technique transiently perturbs the profiles, driving the density profile hollow and flattening the edge temperature profile. After the pellet perturbation, the density…
A numerical study of suspension plasma spraying (SPS) is presented in the current work. The liquid suspension jet is replaced with a train of droplets containing the suspension particles injected into the plasma flow. Atomization,…
Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and…
The goal of this paper is to enable 3D printed lightweight composite foams by blending hollow glass micro balloons (GMB) with high density polyethylene (HDPE). To that end, lightweight feedstock for printing syntactic foam composites is…
In the present work, Jet A-Hexane binary fuel droplet impact dynamics on heated solid surfaces were studied numerically. This study is crucial for practical applications such as fuel injection in combustors and thermal management of engine…
The weakly compressible Smoothed Particle Hydrodynamics (SPH) is known to suffer from the pressure oscillation, which would undermine the simulation stability and accuracy. To address this issue, we propose a generalized density dissipation…
The combustion instability is investigated computationally for a multi-injector rocket engine using the flamelet progress variable (FPV) model. A C++ code is developed based on OpenFOAM 4.0 to apply the combustion model. Flamelet tables are…
First simulations of deuterium shattered pellet injection (SPI) into an ASDEX Upgrade H-Mode plasma with the JOREK MHD code are presented. Resistivity is increased by one order of magnitude in most simulations to reduce computational costs…
We present an extensive experimental study focused on understanding the impact of cavitation in a high-pressure diesel nozzle on the macroscopic properties of fuel spray. Several high-speed videos of the liquid flow through a transparent,…
In this work we present, for the first time, a computational fluid dynamics tool for the simulation of the metered discharge in a pressurized metered dose inhaler. The model, based on open-source software, adopts the Volume-Of-Fluid method…
The combustion instability is investigated computationally for a ten-injector rocket engine using the compressible flamelet progress variable (FPV) model and detached eddy simulation (DES). An C++ code is developed based on OpenFOAM 4.1 to…
The potential of the Dense Plasma Focus (DPF) for industrial applications in many fields is well recognized, although yet to be realized in practice. Particularly attractive is the possibility of its use as inexpensive industrial source of…
The testing of atmosphere-breathing electric propulsion intakes is an important step in the development of functional propulsion systems which provide sustained drag compensation in very low Earth orbits. To make satellite operations more…
We develop a probabilistic, antenna- and propagation-centric framework to quantify the effectiveness of high-power microwave (HPM) engagements against unmanned aerial vehicles (UAVs). The model couples stochastic UAV kinematics, a…
One of the harmful contaminants in the atmosphere, which negatively affects the well-being of both humans and animals, is the suspended respirable particles. The most difficult aspect of the study is now removing these fine respirable…