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Text Image Machine Translation (TIMT)-the task of translating textual content embedded in images-is critical for applications in accessibility, cross-lingual information access, and real-world document understanding. However, TIMT remains a…

计算与语言 · 计算机科学 2025-05-27 Zhaopeng Feng , Yupu Liang , Shaosheng Cao , Jiayuan Su , Jiahan Ren , Zhe Xu , Yao Hu , Wenxuan Huang , Jian Wu , Zuozhu Liu

Studying protein mutations within amino acid sequences holds tremendous significance in life sciences. Protein language models (PLMs) have demonstrated strong capabilities in broad biological applications. However, due to architectural…

机器学习 · 计算机科学 2024-10-31 Yizhen Luo , Zikun Nie , Massimo Hong , Suyuan Zhao , Hao Zhou , Zaiqing Nie

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

机器学习 · 计算机科学 2024-10-17 Xinyou Wang , Zaixiang Zheng , Fei Ye , Dongyu Xue , Shujian Huang , Quanquan Gu

Reparameterized diffusion models (RDMs) have recently matched autoregressive methods in protein generation, motivating their use for challenging tasks such as designing membrane proteins, which possess interleaved soluble and transmembrane…

生物大分子 · 定量生物学 2025-09-30 Shrey Goel , Peregrine M. Schray , Yinuo Zhang , Sophia Vincoff , Huong T. Kratochvil , Pranam Chatterjee

Fine-tuned pre-trained language models (PLMs) have achieved awesome performance on almost all NLP tasks. By using additional prompts to fine-tune PLMs, we can further stimulate the rich knowledge distributed in PLMs to better serve…

计算与语言 · 计算机科学 2021-09-16 Xu Han , Weilin Zhao , Ning Ding , Zhiyuan Liu , Maosong Sun

Recent advances in Neural Machine Translation (NMT) show that adding syntactic information to NMT systems can improve the quality of their translations. Most existing work utilizes some specific types of linguistically-inspired tree…

计算与语言 · 计算机科学 2018-08-29 Xinyi Wang , Hieu Pham , Pengcheng Yin , Graham Neubig

Pre-trained large language models (LLM) are starting to be widely used in many applications. In this work, we explore the use of these models in interactive machine translation (IMT) environments. In particular, we have chosen mBART…

计算与语言 · 计算机科学 2024-07-10 Angel Navarro , Francisco Casacuberta

Consistency is a key requirement of high-quality translation. It is especially important to adhere to pre-approved terminology and adapt to corrected translations in domain-specific projects. Machine translation (MT) has achieved…

计算与语言 · 计算机科学 2023-05-10 Yasmin Moslem , Rejwanul Haque , John D. Kelleher , Andy Way

Pretrained language models (PTLMs) are typically learned over a large, static corpus and further fine-tuned for various downstream tasks. However, when deployed in the real world, a PTLM-based model must deal with data distributions that…

计算与语言 · 计算机科学 2022-07-20 Xisen Jin , Dejiao Zhang , Henghui Zhu , Wei Xiao , Shang-Wen Li , Xiaokai Wei , Andrew Arnold , Xiang Ren

Protein language models (PLMs) have revolutionised computational biology through their ability to generate powerful sequence representations for diverse prediction tasks. However, their black-box nature limits biological interpretation and…

生物大分子 · 定量生物学 2025-04-11 Jan van Eck , Dea Gogishvili , Wilson Silva , Sanne Abeln

The prediction of amyloidogenicity in peptides and proteins remains a focal point of ongoing bioinformatics. The crucial step in this field is to apply advanced computational methodologies. Many recent approaches to predicting…

机器学习 · 计算机科学 2025-08-19 Zohra Yagoub , Hafida Bouziane

Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base…

人工智能 · 计算机科学 2025-02-04 L. I. Zablocki , L. A. Bugnon , M. Gerard , L. Di Persia , G. Stegmayer , D. H. Milone

Large language models (LLMs) pretrained on vast source code have achieved prominent progress in code intelligence. However, existing code LLMs have two main limitations in terms of architecture and pretraining tasks. First, they often adopt…

计算与语言 · 计算机科学 2023-05-23 Yue Wang , Hung Le , Akhilesh Deepak Gotmare , Nghi D. Q. Bui , Junnan Li , Steven C. H. Hoi

Emotion recognition from speech is a challenging task that requires capturing both linguistic and paralinguistic cues, with critical applications in human-computer interaction and mental health monitoring. Recent works have highlighted the…

音频与语音处理 · 电气工程与系统科学 2025-08-21 Hugo Thimonier , Antony Perzo , Renaud Seguier

Pre-trained Language Model (PLM) has become a representative foundation model in the natural language processing field. Most PLMs are trained with linguistic-agnostic pre-training tasks on the surface form of the text, such as the masked…

计算与语言 · 计算机科学 2022-11-11 Yiming Cui , Wanxiang Che , Shijin Wang , Ting Liu

Identification of protein-protein interactions (PPIs) helps derive cellular mechanistic understanding, particularly in the context of complex conditions such as neurodegenerative disorders, metabolic syndromes, and cancer. Large Language…

The advent of Multilingual Language Models (MLLMs) and Large Language Models has spawned innovation in many areas of natural language processing. Despite the exciting potential of this technology, its impact on developing high-quality…

计算与语言 · 计算机科学 2024-03-06 Séamus Lankford , Haithem Afli , Andy Way

The adaptive immune response, largely mediated by B-cell receptors (BCRs), plays a crucial role for effective pathogen neutralization due to its diversity and antigen specificity. Designing BCRs de novo, or from scratch, has been…

生物大分子 · 定量生物学 2024-09-11 Desmond Kuan , Amir Barati Farimani

Proteins are complex biomolecules that play a central role in various biological processes, making them critical targets for breakthroughs in molecular biology, medical research, and drug discovery. Deciphering their intricate, hierarchical…

机器学习 · 计算机科学 2025-05-09 Viet Thanh Duy Nguyen , Truong-Son Hy

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

生物大分子 · 定量生物学 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez