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Live-cell imaging of multiple subcellular structures is essential for understanding subcellular dynamics. However, the conventional multi-color sequential fluorescence microscopy suffers from significant imaging delays and limited number of…

亚细胞过程 · 定量生物学 2025-01-13 Mingyang Chen , Luhong Jin , Xuwei Xuan , Defu Yang , Yun Cheng , Ju Zhang

Recent advances in deep learning have enabled the development of automated frameworks for analysing medical images and signals, including analysis of cervical cancer. Many previous works focus on the analysis of isolated cervical cells, or…

计算机视觉与模式识别 · 计算机科学 2024-03-06 Ruiqi Wang , Mohammad Ali Armin , Simon Denman , Lars Petersson , David Ahmedt-Aristizabal

Clinical cystoscopy, the current standard for bladder cancer diagnosis, suffers from significant reliance on physician expertise, leading to variability and subjectivity in diagnostic outcomes. There is an urgent need for objective,…

图像与视频处理 · 电气工程与系统科学 2025-08-22 Jinliang Yu , Mingduo Xie , Yue Wang , Tianfan Fu , Xianglai Xu , Jiajun Wang

Counting cells in fluorescent microscopy is a tedious, time-consuming task that researchers have to accomplish to assess the effects of different experimental conditions on biological structures of interest. Although such objects are…

计算机视觉与模式识别 · 计算机科学 2021-03-02 R. Morelli , L. Clissa , M. Dalla , M. Luppi , L. Rinaldi , A. Zoccoli

Fine-grained classification of microscopic image data with limited samples is an open problem in computer vision and biomedical imaging. Deep learning based vision systems mostly deal with high number of low-resolution images, whereas…

计算机视觉与模式识别 · 计算机科学 2020-10-07 Mengran Fan , Tapabrata Chakrabort , Eric I-Chao Chang , Yan Xu , Jens Rittscher

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

计算机视觉与模式识别 · 计算机科学 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly

Cell instance segmentation in fluorescence microscopy images is becoming essential for cancer dynamics and prognosis. Data extracted from cancer dynamics allows to understand and accurately model different metabolic processes such as…

Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…

图像与视频处理 · 电气工程与系统科学 2024-11-07 Simon Gutwein , Daria Lazic , Thomas Walter , Sabine Taschner-Mandl , Roxane Licandro

We propose a general framework for a collaborative machine learning system to assist bioscience researchers with the task of labeling specific cell identities from microscopic still or video imaging. The distinguishing features of this…

定量方法 · 定量生物学 2019-03-25 Greg Bubnis , Steven Ban , Matthew D. DiFranco , Saul Kato

Explainability for Deep Learning Models is especially important for clinical applications, where decisions of automated systems have far-reaching consequences. While various post-hoc explainable methods, such as attention visualization and…

Fluorescence microscopy allows for a detailed inspection of cells, cellular networks, and anatomical landmarks by staining with a variety of carefully-selected markers visualized as color channels. Quantitative characterization of…

计算机视觉与模式识别 · 计算机科学 2021-08-26 Alvaro Gomariz , Tiziano Portenier , Patrick M. Helbling , Stephan Isringhausen , Ute Suessbier , César Nombela-Arrieta , Orcun Goksel

Detecting and segmenting brain metastases is a tedious and time-consuming task for many radiologists, particularly with the growing use of multi-sequence 3D imaging. This study demonstrates automated detection and segmentation of brain…

图像与视频处理 · 电气工程与系统科学 2019-12-30 Endre Grøvik , Darvin Yi , Michael Iv , Elisabeth Tong , Daniel L. Rubin , Greg Zaharchuk

Brain tumor detection can make the difference between life and death. Recently, deep learning-based brain tumor detection techniques have gained attention due to their higher performance. However, obtaining the expected performance of such…

图像与视频处理 · 电气工程与系统科学 2022-02-22 Wessam M. Salama , Ahmed Shokry

Breast cancer is the most diagnosed cancer and the most predominant cause of death in women worldwide. Imaging techniques such as the breast cancer pathology helps in the diagnosis and monitoring of the disease. However identification of…

图像与视频处理 · 电气工程与系统科学 2019-08-06 Francisco Perdigon Romero , An Tang , Samuel Kadoury

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

图像与视频处理 · 电气工程与系统科学 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

Automatic cell segmentation is an essential step in the pipeline of computer-aided diagnosis (CAD), such as the detection and grading of breast cancer. Accurate segmentation of cells can not only assist the pathologists to make a more…

图像与视频处理 · 电气工程与系统科学 2020-12-29 Muyi Sun , Zeyi Yao , Guanhong Zhang

In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The…

光学 · 物理学 2021-01-07 Antoine Boniface , Jonathan Dong , Sylvain Gigan

Recent studies have demonstrated the superiority of deep learning in medical image analysis, especially in cell instance segmentation, a fundamental step for many biological studies. However, the excellent performance of the neural networks…

图像与视频处理 · 电气工程与系统科学 2022-10-25 Huaqian Wu , Nicolas Souedet , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual…

Fluorescence microscopy plays a vital role in understanding the subcellular structures of living cells. However, it requires considerable effort in sample preparation related to chemical fixation, staining, cost, and time. To reduce those…

图像与视频处理 · 电气工程与系统科学 2020-12-02 Thanh Nguyen , Vy Bui , Anh Thai , Van Lam , Christopher B. Raub , Lin-Ching Chang , George Nehmetallah
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