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Segmentation of nuclei regions from histological images is an important task for automated computer-aided analysis of histological images, particularly in the presence of impermissible color variation in the color appearance of stained…

图像与视频处理 · 电气工程与系统科学 2025-06-10 Suman Mahapatra , Pradipta Maji

Semantic segmentation in a supervised learning manner has achieved significant progress in recent years. However, its performance usually drops dramatically due to the data-distribution discrepancy between seen and unseen domains when we…

计算机视觉与模式识别 · 计算机科学 2021-09-01 Jian Zhang , Lei Qi , Yinghuan Shi , Yang Gao

For medical image analysis, segmentation models trained on one or several domains lack generalization ability to unseen domains due to discrepancies between different data acquisition policies. We argue that the degeneration in segmentation…

计算机视觉与模式识别 · 计算机科学 2022-08-09 Ziqi Zhou , Lei Qi , Yinghuan Shi

Ki67 is a significant biomarker in the diagnosis and prognosis of cancer, whose index can be evaluated by quantifying its expression in Ki67 immunohistochemistry (IHC) stained images. However, quantitative analysis on multi-source Ki67…

计算机视觉与模式识别 · 计算机科学 2021-07-07 Jiatong Cai , Chenglu Zhu , Can Cui , Honglin Li , Tong Wu , Shichuan Zhang , Lin Yang

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained…

计算机视觉与模式识别 · 计算机科学 2026-04-09 Reiji Saito , Kazuhiro Hotta

The different stain styles of cytopathological images have a negative effect on the generalization ability of automated image analysis algorithms. This article proposes a new framework that normalizes the stain style for cytopathological…

图像与视频处理 · 电气工程与系统科学 2019-09-12 Xihao Chen , Jingya Yu , Li Chen , Shaoqun Zeng , Xiuli Liu , Shenghua Cheng

For medical image segmentation, imagine if a model was only trained using MR images in source domain, how about its performance to directly segment CT images in target domain? This setting, namely generalizable cross-modality segmentation,…

计算机视觉与模式识别 · 计算机科学 2022-03-29 Ziqi Zhou , Lei Qi , Xin Yang , Dong Ni , Yinghuan Shi

Since the introduction of digital and computational pathology as a field, one of the major problems in the clinical application of algorithms has been the struggle to generalize well to examples outside the distribution of the training…

图像与视频处理 · 电气工程与系统科学 2023-01-10 Quoc Dang Vu , Robert Jewsbury , Simon Graham , Mostafa Jahanifar , Shan E Ahmed Raza , Fayyaz Minhas , Abhir Bhalerao , Nasir Rajpoot

The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

图像与视频处理 · 电气工程与系统科学 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

Autonomous driving is a challenging scenario for image segmentation due to the presence of uncontrolled environmental conditions and the eventually catastrophic consequences of failures. Previous work suggested that a biologically motivated…

计算机视觉与模式识别 · 计算机科学 2026-04-01 Pablo Hernández-Cámara , Jorge Vila-Tomás , Paula Dauden-Oliver , Nuria Alabau-Bosque , Valero Laparra , Jesús Malo

The domain gap caused mainly by variable medical image quality renders a major obstacle on the path between training a segmentation model in the lab and applying the trained model to unseen clinical data. To address this issue, domain…

图像与视频处理 · 电气工程与系统科学 2022-09-27 Shishuai Hu , Zehui Liao , Jianpeng Zhang , Yong Xia

Convolutional Neural Networks (CNNs) show impressive performance in the standard classification setting where training and testing data are drawn i.i.d. from a given domain. However, CNNs do not readily generalize to new domains with…

计算机视觉与模式识别 · 计算机科学 2020-07-13 Nathan Somavarapu , Chih-Yao Ma , Zsolt Kira

Unsupervised domain adaptation (UDA) for nuclei instance segmentation is important for digital pathology, as it alleviates the burden of labor-intensive annotation and domain shift across datasets. In this work, we propose a Cycle…

计算机视觉与模式识别 · 计算机科学 2020-05-06 Dongnan Liu , Donghao Zhang , Yang Song , Fan Zhang , Lauren O'Donnell , Heng Huang , Mei Chen , Weidong Cai

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…

计算机视觉与模式识别 · 计算机科学 2026-04-29 Franz Thaler , Martin Urschler , Mateusz Kozinski , Matthias AF Gsell , Gernot Plank , Darko Stern

Deep learning advances have revolutionized automated digital pathology analysis. However, differences in staining protocols and imaging conditions can introduce significant color variability. In deep learning, such color inconsistency often…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Tianyue Xu , Yanlin Wu , Abhai K. Tripathi , Matthew M. Ippolito , Benjamin D. Haeffele

Single-source domain generalization (SDG) in medical image segmentation remains a significant challenge, particularly for images with varying color distributions and qualities. Previous approaches often struggle when models trained on…

图像与视频处理 · 电气工程与系统科学 2025-02-12 Ravi Shah , Atsushi Fukuda , Quan Huu Cap

With the advent of digital pathology and microscopic systems that can scan and save whole slide histological images automatically, there is a growing trend to use computerized methods to analyze acquired images. Among different…

图像与视频处理 · 电气工程与系统科学 2024-01-10 Amirreza Mahbod , Georg Dorffner , Isabella Ellinger , Ramona Woitek , Sepideh Hatamikia

In search of robust and generalizable machine learning models, Domain Generalization (DG) has gained significant traction during the past few years. The goal in DG is to produce models which continue to perform well when presented with data…

计算机视觉与模式识别 · 计算机科学 2023-12-05 Aristotelis Ballas , Christos Diou

Accurate cell instance segmentation is foundational for digital pathology analysis. Existing methods based on contour detection and distance mapping still face significant challenges in processing complex and dense cellular regions. Graph…

计算机视觉与模式识别 · 计算机科学 2026-02-06 Rui Sun , Yiwen Yang , Kaiyu Guo , Chen Jiang , Dongli Xu , Zhaonan Liu , Tan Pan , Limei Han , Xue Jiang , Wu Wei , Yuan Cheng

Nuclear segmentation and classification is an essential step for computational pathology. TIA lab from Warwick University organized a nuclear segmentation and classification challenge (CoNIC) for H&E stained histopathology images in…

图像与视频处理 · 电气工程与系统科学 2022-03-22 Jijun Cheng , Xipeng Pan , Feihu Hou , Bingchao Zhao , Jiatai Lin , Zhenbing Liu , Zaiyi Liu , Chu Han
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