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Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

机器学习 · 计算机科学 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

统计方法学 · 统计学 2026-03-27 Alex Chen , Qing Zhou

Adjusting for latent covariates is crucial for estimating causal effects from observational textual data. Most existing methods only account for confounding covariates that affect both treatment and outcome, potentially leading to biased…

计算与语言 · 计算机科学 2023-11-27 Yuxiang Zhou , Yulan He

Researchers commonly use difference-in-differences (DiD) designs to evaluate public policy interventions. While methods exist for estimating effects in the context of binary interventions, policies often result in varied exposures across…

统计方法学 · 统计学 2025-02-07 Gary Hettinger , Youjin Lee , Nandita Mitra

Mediation analysis has become a widely used method for identifying the pathways through which an independent variable influences a dependent variable via intermediate mediators. However, limited research addresses the case where mediators…

统计方法学 · 统计学 2025-06-10 Rui Ren , Haoyi Yang , Qian Xiao , Lingzhou Xue , Yuan Huang

Mediation analysis extending beyond single mediators has gained significant attention in recent years. However, related methods often assume the absence of unmeasured mediator-outcome confounding. To address this, we develop a mediation…

统计方法学 · 统计学 2026-03-31 Kang Shuai , Lan Liu , Yangbo He , Wei Li

Clinical decisions to treat and diagnose patients are affected by implicit biases formed by racism, ableism, sexism, and other stereotypes. These biases reflect broader systemic discrimination in healthcare and risk marginalizing already…

机器学习 · 计算机科学 2025-01-29 Kara Liu , Russ Altman , Vasilis Syrgkanis

Adjusting for covariates is a well established method to estimate the total causal effect of an exposure variable on an outcome of interest. Depending on the causal structure of the mechanism under study there may be different adjustment…

统计理论 · 数学 2021-04-27 Jack Kuipers , Giusi Moffa

When estimating causal effects using observational data, it is desirable to replicate a randomized experiment as closely as possible by obtaining treated and control groups with similar covariate distributions. This goal can often be…

统计方法学 · 统计学 2010-10-28 Elizabeth A. Stuart

Linear causal disentanglement is a recent method in causal representation learning to describe a collection of observed variables via latent variables with causal dependencies between them. It can be viewed as a generalization of both…

机器学习 · 统计学 2024-07-08 Paula Leyes Carreno , Chiara Meroni , Anna Seigal

We consider the problem of assessing whether, in an individual case, there is a causal relationship between an observed exposure and a response variable. When data are available on similar individuals we may be able to estimate prospective…

统计理论 · 数学 2023-11-15 Monica Musio , Philip Dawid

Causal decomposition depicts a cause-effect relationship that is not based on the concept of prediction, but based on the phase dependence of time series. It has been validated in both stochastic and deterministic systems and is now…

信号处理 · 电气工程与系统科学 2020-08-18 Yi Zhang , Qin Yang , Lifu Zhang , Branko Celler , Steven Su , Peng Xu , Dezhong Yao

In causal analysis, understanding the causal mechanisms through which an intervention or treatment affects an outcome is often of central interest. We propose a test to evaluate (i) whether the causal effect of a treatment that is randomly…

计量经济学 · 经济学 2026-03-05 Martin Huber , Kevin Kloiber , Lukáš Lafférs

Comparing outcomes across treatments is essential in medicine and public policy. To do so, researchers typically estimate a set of parameters, possibly counterfactual, with each targeting a different treatment. Treatment-specific means are…

统计方法学 · 统计学 2025-10-07 Alec McClean , Yiting Li , Sunjae Bae , Mara A. McAdams-DeMarco , Iván Díaz , Wenbo Wu

Conditioning on some set of confounders that causally affect both treatment and outcome variables can be sufficient for eliminating bias introduced by all such confounders when estimating causal effect of the treatment on the outcome from…

统计方法学 · 统计学 2018-04-24 Priyantha Wijayatunga

This paper aims to provide practitioners of causal mediation analysis with a better understanding of estimation options. We take as inputs two familiar strategies (weighting and model-based prediction) and a simple way of combining them…

Algorithmic fairness has aroused considerable interests in data mining and machine learning communities recently. So far the existing research has been mostly focusing on the development of quantitative metrics to measure algorithm…

机器学习 · 计算机科学 2021-08-12 Weishen Pan , Sen Cui , Jiang Bian , Changshui Zhang , Fei Wang

The incorporation of causal inference in mediation analysis has led to theoretical and methodological advancements -- effect definitions with causal interpretation, clarification of assumptions required for effect identification, and an…

统计方法学 · 统计学 2022-10-31 Trang Quynh Nguyen , Ian Schmid , Elizabeth A. Stuart

Causal disentanglement aims to uncover a representation of data using latent variables that are interrelated through a causal model. Such a representation is identifiable if the latent model that explains the data is unique. In this paper,…

Traditional mediation analysis typically examines the relations among an intervention, a time-invariant mediator, and a time-invariant outcome variable. Although there may be a direct effect of the intervention on the outcome, there is a…

应用统计 · 统计学 2020-08-28 Xizhen Cai , Donna L. Coffman , Megan E. Piper , Runze Li