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By interpreting the forward dynamics of the latent representation of neural networks as an ordinary differential equation, Neural Ordinary Differential Equation (Neural ODE) emerged as an effective framework for modeling a system dynamics…

机器学习 · 计算机科学 2020-10-19 Daehoon Gwak , Gyuhyeon Sim , Michael Poli , Stefano Massaroli , Jaegul Choo , Edward Choi

Mechanistic dynamic models of biochemical networks such as Ordinary Differential Equations (ODEs) contain unknown parameters like the reaction rate constants and the initial concentrations of the compounds. The large number of parameters as…

数据分析、统计与概率 · 物理学 2017-08-14 Clemens Kreutz , Andreas Raue , Jens Timmer

Ordinary differential equations (ODEs) are a mathematical model used in many application areas such as climatology, bioinformatics, and chemical engineering with its intuitive appeal to modeling. Despite ODE's wide usage in modeling, the…

应用统计 · 统计学 2021-08-10 Hyunjoo Yang , Jaeyong Lee

Statistical models can involve implicitly defined quantities, such as solutions to nonlinear ordinary differential equations (ODEs), that unavoidably need to be numerically approximated in order to evaluate the model. The approximation…

统计计算 · 统计学 2024-09-16 Juho Timonen , Nikolas Siccha , Ben Bales , Harri Lähdesmäki , Aki Vehtari

Traditional survival models often rely on restrictive assumptions such as proportional hazards or instantaneous effects of time-varying covariates on the hazard function, which limit their applicability in real-world settings. We consider…

统计方法学 · 统计学 2025-05-30 Bingqing Hu , Bin Nan

Ordinary differential equation (ODE) models are widely used to describe systems in many areas of science. To ensure these models provide accurate and interpretable representations of real-world dynamics, it is often necessary to infer…

统计方法学 · 统计学 2026-03-24 Selva Salimi , David J. Warne , Christopher Drovandi

We introduce a numerically tractable formulation of Bayesian joint models for longitudinal and survival data. The longitudinal process is modelled using generalised linear mixed models, while the survival process is modelled using a…

统计方法学 · 统计学 2021-04-23 Danilo Alvares , Francisco Javier Rubio

Inferring the parameters of ordinary differential equations (ODEs) from noisy observations is an important problem in many scientific fields. Currently, most parameter estimation methods that bypass numerical integration tend to rely on…

统计方法学 · 统计学 2023-10-25 Mingwei Xu , Samuel W. K. Wong , Peijun Sang

Regular and rapid variation have been extensively studied in the literature and applied across various fields, particularly in extreme value theory. In this paper, we examine regular and rapid variation through the lens of generalized…

概率论 · 数学 2025-04-17 Haijun Li

Statistical regression models whose mean functions are represented by ordinary differential equations (ODEs) can be used to describe phenomenons dynamical in nature, which are abundant in areas such as biology, climatology and genetics. The…

统计方法学 · 统计学 2017-05-15 Kyoungjae Lee , Jaeyong Lee , Sarat C. Dass

Neural ordinary differential equations (Neural ODEs) is a class of machine learning models that approximate the time derivative of hidden states using a neural network. They are powerful tools for modeling continuous-time dynamical systems,…

机器学习 · 统计学 2024-07-16 Wenbo Hao

The order/dimension of models derived on the basis of data is commonly restricted by the number of observations, or in the context of monitored systems, sensing nodes. This is particularly true for structural systems (e.g., civil or…

机器学习 · 计算机科学 2022-12-01 Zhilu Lai , Wei Liu , Xudong Jian , Kiran Bacsa , Limin Sun , Eleni Chatzi

Ordinary differential equations (ODEs) are widely used to model dynamical behavior of systems. It is important to perform identifiability analysis prior to estimating unknown parameters in ODEs (a.k.a. inverse problem), because if a system…

最优化与控制 · 数学 2021-03-11 Xing Qiu , Tao Xu , Babak Soltanalizadeh , Hulin Wu

Autonomous vehicles (AV) look set to become common on our roads within the next few years. However, to achieve the final breakthrough, not only functional progress is required, but also satisfactory safety assurance must be provided. Among…

机器人学 · 计算机科学 2025-06-04 Peter Popov , Lorenzo Strigini , Cornelius Buerkle , Fabian Oboril , Michael Paulitsch

Survival analysis, or time-to-event modelling, is a classical statistical problem that has garnered a lot of interest for its practical use in epidemiology, demographics or actuarial sciences. Recent advances on the subject from the point…

机器学习 · 计算机科学 2021-07-28 Guillaume Ausset , Tom Ciffreo , Francois Portier , Stephan Clémençon , Timothée Papin

Survival Analysis (SA) constitutes the default method for time-to-event modeling due to its ability to estimate event probabilities of sparsely occurring events over time. In this work, we show how to improve the training and inference of…

机器学习 · 计算机科学 2023-12-12 Chris Solomou

The Proportional Hazards (PH) model is one of the most widely used models in survival analysis, typically assuming a log-linear relationship between covariates and the hazard function. However, in the context of spatial survival data, where…

统计方法学 · 统计学 2026-02-17 Lorenzo Tedesco , Francesco Finazzi

Stochastic compartmental models are prevalent tools for describing disease spread, but inference under these models is challenging for many types of surveillance data when the marginal likelihood function becomes intractable due to missing…

统计方法学 · 统计学 2026-02-05 Suchismita Roy , Alexander A. Fisher , Jason Xu

In this paper, we model dependence between operational risks by allowing risk profiles to evolve stochastically in time and to be dependent. This allows for a flexible correlation structure where the dependence between frequencies of…

风险管理 · 定量金融 2009-07-31 Gareth W. Peters , Pavel V. Shevchenko , Mario V. Wüthrich

Ordinary differential equations (ODEs) are used to model dynamic systems appearing in engineering, physics, biomedical sciences and many other fields. These equations contain unknown parameters, say $\theta$ of physical significance which…

统计理论 · 数学 2014-03-05 Prithwish Bhaumik , Subhashis Ghosal