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Gene annotation has traditionally required direct comparison of DNA sequences between an unknown gene and a database of known ones using string comparison methods. However, these methods do not provide useful information when a gene does…

机器学习 · 计算机科学 2019-09-17 James K. Senter , Taylor M. Royalty , Andrew D. Steen , Amir Sadovnik

Minimizing data storage poses a significant challenge in large-scale metagenomic projects. In this paper, we present a new method for improving the encoding of FASTQ files generated by metagenomic sequencing. This method incorporates…

信息论 · 计算机科学 2024-01-04 Diogo Pratas , Armando J. Pinho

Biological sequence comparison is a key step in inferring the relatedness of various organisms and the functional similarity of their components. Thanks to the Next Generation Sequencing efforts, an abundance of sequence data is now…

机器学习 · 计算机科学 2016-09-13 Dhananjay Kimothi , Akshay Soni , Pravesh Biyani , James M. Hogan

In a distributed information application an encoder compresses an arbitrary vector while a similar reference vector is available to the decoder as side information. For the Hamming-distance similarity measure, and when guaranteed perfect…

信息论 · 计算机科学 2020-09-08 Yuval Cassuto , Jacob Ziv

Embedding vectors are widely used for representing unstructured data and searching through it for semantically similar items. However, the large size of these vectors, due to their high-dimensionality, creates problems for modern vector…

机器学习 · 计算机科学 2025-09-24 Mariano Tepper , Ted Willke

The metadata about scientific experiments published in online repositories have been shown to suffer from a high degree of representational heterogeneity---there are often many ways to represent the same type of information, such as a…

计算与语言 · 计算机科学 2020-12-17 Rafael S. Gonçalves , Maulik R. Kamdar , Mark A. Musen

Traditional retrieval methods have been essential for assessing document similarity but struggle with capturing semantic nuances. Despite advancements in latent semantic analysis (LSA) and deep learning, achieving comprehensive semantic…

信息检索 · 计算机科学 2024-09-27 Solmaz Seyed Monir , Irene Lau , Shubing Yang , Dongfang Zhao

Machine learning for data-driven diagnosis has been actively studied in medicine to provide better healthcare. Supporting analysis of a patient cohort similar to a patient under treatment is a key task for clinicians to make decisions with…

医学物理 · 物理学 2020-03-25 Rongchen Guo , Takanori Fujiwara , Yiran Li , Kelly M. Lima , Soman Sen , Nam K. Tran , Kwan-Liu Ma

Similarity query is the family of queries based on some similarity metrics. Unlike the traditional database queries which are mostly based on value equality, similarity queries aim to find targets "similar enough to" the given data objects,…

数据库 · 计算机科学 2022-04-19 Yifan Wang

Nowadays, data is represented by vectors. Retrieving those vectors, among millions and billions, that are similar to a given query is a ubiquitous problem, known as similarity search, of relevance for a wide range of applications.…

机器学习 · 计算机科学 2023-07-26 Cecilia Aguerrebere , Ishwar Bhati , Mark Hildebrand , Mariano Tepper , Ted Willke

DNA sequence alignment involves assigning short DNA reads to the most probable locations on an extensive reference genome. This process is crucial for various genomic analyses, including variant calling, transcriptomics, and epigenomics.…

The Basic Local Alignment Search Tool (BLAST) is currently the most popular method for searching databases of biological sequences. BLAST compares sequences via similarity defined by a weighted edit distance, which results in it being…

生物大分子 · 定量生物学 2020-10-29 Amir Shanehsazzadeh , David Belanger , David Dohan

This paper proposes a novel framework for accelerating support vector clustering. The proposed method first computes much smaller compressed data sets while preserving the key cluster properties of the original data sets based on a novel…

机器学习 · 计算机科学 2023-05-16 Yuxuan Song , Yongyu Wang

Vectors of data are at the heart of machine learning and data mining. Recently, vector quantization methods have shown great promise in reducing both the time and space costs of operating on vectors. We introduce a vector quantization…

性能 · 计算机科学 2017-07-03 Davis W Blalock , John V Guttag

Single-cell RNA sequencing (scRNA-seq) provides unprecedented insights into cellular heterogeneity, enabling detailed analysis of complex biological systems at single-cell resolution. However, the high dimensionality and technical noise…

基因组学 · 定量生物学 2025-09-04 Hojjat Torabi Goudarzi , Maziyar Baran Pouyan

Dense Retrieval (DR) has achieved state-of-the-art first-stage ranking effectiveness. However, the efficiency of most existing DR models is limited by the large memory cost of storing dense vectors and the time-consuming nearest neighbor…

信息检索 · 计算机科学 2021-10-13 Jingtao Zhan , Jiaxin Mao , Yiqun Liu , Jiafeng Guo , Min Zhang , Shaoping Ma

Vector Quantization (VQ) is an appealing model compression method to obtain a tiny model with less accuracy loss. While methods to obtain better codebooks and codes under fixed clustering dimensionality have been extensively studied,…

计算机视觉与模式识别 · 计算机科学 2022-11-22 Zezhou Zhu , Yucong Zhou , Zhao Zhong

We present a feature vector formation technique for documents - Sparse Composite Document Vector (SCDV) - which overcomes several shortcomings of the current distributional paragraph vector representations that are widely used for text…

计算与语言 · 计算机科学 2017-05-15 Dheeraj Mekala , Vivek Gupta , Bhargavi Paranjape , Harish Karnick

The exponential growth of DNA sequencing data has outpaced traditional heuristic-based methods, which struggle to scale effectively. Efficient computational approaches are urgently needed to support large-scale similarity search, a…

The use of deep neural network (DNN) autoencoders (AEs) has recently exploded due to their wide applicability. However, the embedding representation produced by a standard DNN AE that is trained to minimize only the reconstruction error…

机器学习 · 计算机科学 2020-11-20 Mark Alan Matties
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