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Coronary artery disease (CAD) is one of the most common causes of death in the European Union and the USA. The crucial biomarker in its diagnosis is called Fractional Flow Reserve (FFR) and its in-vivo measurement is obtained via an…

图像与视频处理 · 电气工程与系统科学 2024-05-22 Patryk Rygiel

Coronary Artery Disease (CAD) is one of the most common forms of heart disease, which is caused by a buildup of atherosclerotic plaque (known as stenosis) in the coronary arteries, leading to insufficient supplement of blood, oxygen, and…

计算工程、金融与科学 · 计算机科学 2024-09-06 Haizhou Yang , C. Alberto Figueroa , Krishna Garikipati

In patients with obstructive coronary artery disease, the functional significance of a coronary artery stenosis needs to be determined to guide treatment. This is typically established through fractional flow reserve (FFR) measurement,…

图像与视频处理 · 电气工程与系统科学 2019-11-12 Majd Zreik , Robbert W. van Hamersvelt , Nadieh Khalili , Jelmer M. Wolterink , Michiel Voskuil , Max A. Viergever , Tim Leiner , Ivana Išgum

In patients with coronary artery stenoses of intermediate severity, the functional significance needs to be determined. Fractional flow reserve (FFR) measurement, performed during invasive coronary angiography (ICA), is most often used in…

计算机视觉与模式识别 · 计算机科学 2018-08-21 Majd Zreik , Nikolas Lessmann , Robbert W. van Hamersvelt , Jelmer M. Wolterink , Michiel Voskuil , Max A. Viergever , Tim Leiner , Ivana Išgum

Analysing coronary artery plaque segments with respect to their functional significance and therefore their influence to patient management in a non-invasive setup is an important subject of current research. In this work we compare and…

图像与视频处理 · 电气工程与系统科学 2019-12-16 Felix Denzinger , Michael Wels , Katharina Breininger , Anika Reidelshöfer , Joachim Eckert , Michael Sühling , Axel Schmermund , Andreas Maier

Assessing coronary artery plaque segments in coronary CT angiography scans is an important task to improve patient management and clinical outcomes, as it can help to decide whether invasive investigation and treatment are necessary. In…

Treatment of patients with obstructive coronary artery disease is guided by the functional significance of a coronary artery stenosis. Fractional flow reserve (FFR), measured during invasive coronary angiography (ICA), is considered the…

图像与视频处理 · 电气工程与系统科学 2019-11-13 Majd Zreik , Tim Leiner , Nadieh Khalili , Robbert W. van Hamersvelt , Jelmer M. Wolterink , Michiel Voskuil , Max A. Viergever , Ivana Išgum

Coronary CT angiography (CCTA) has established its role as a non-invasive modality for the diagnosis of coronary artery disease (CAD). The CAD-Reporting and Data System (CAD-RADS) has been developed to standardize communication and aid in…

Coronary heart disease (CHD) remains a top reason of mortality worldwide. This study introduces a novel approach by integrating patient-specific Multi-slice CT scans into CAD models and employing a one-dimensional numerical framework to…

医学物理 · 物理学 2025-07-01 Oeshee Roy , Priyanshu Ghosh , Sayan Karmakar , Supratim Saha

Computational fluid dynamics (CFD) based simulation of coronary blood flow provides valuable hemodynamic markers, such as pressure gradients, for diagnosing coronary artery disease (CAD). However, CFD is computationally expensive,…

计算机视觉与模式识别 · 计算机科学 2025-12-12 Rene Lisasi , Michele Esposito , Chen Zhao

Prediction of the blood flow characteristics is of utmost importance for understanding the behavior of the blood arterial network, especially in the presence of vascular diseases such as stenosis. Computational fluid dynamics (CFD) has…

机器学习 · 计算机科学 2021-11-11 Mohammad Farajtabar , Mohit Biglarian , Morteza Miansari

Purpose of Review Imaging derived fractional flow reserve (FFR) is rapidly evolving beyond conventional computational fluid dynamics (CFD) based pipelines toward machine learning (ML), deep learning (DL), and physics informed approaches…

医学物理 · 物理学 2026-04-08 Tanxin Zhu , Emran Hossen , Chen Zhao , Jingfeng Jiang , Michele Esposito , Jiguang Sun , Weihua Zhou

Background: Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide. Precise segmentation of coronary arteries from invasive coronary angiography (ICA) is critical for effective clinical decision-making.…

图像与视频处理 · 电气工程与系统科学 2025-06-16 Nan Mu , Ruiqi Song , Xiaoning Li , Zhihui Xu , Jingfeng Jiang , Chen Zhao

Local hemodynamic forces play an important role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) have been widely…

计算机视觉与模式识别 · 计算机科学 2023-05-31 Ziyu Ni , Linda Wei , Lijian Xu , Simon Yu , Qing Xia , Hongsheng Li , Shaoting Zhang

Coronary artery disease (CAD) is the dominant cause of death and hospitalization across the globe. Atherosclerosis, an inflammatory condition that gradually narrows arteries and has potentially fatal effects, is the most frequent cause of…

The standard non-invasive imaging technique used to assess the severity and extent of Coronary Artery Disease (CAD) is Coronary Computed Tomography Angiography (CCTA). However, manual grading of each patient's CCTA according to the…

Fractional flow reserve (FFR) is the gold standard for diagnosing coronary artery disease (CAD). FFRCT uses computational fluid dynamics (CFD) to evaluate FFR non-invasively by simulating coronary flow in geometries reconstructed from…

Coronary artery disease (CAD) remains a leading cause of mortality worldwide, requiring accurate segmentation and stenosis detection using Coronary Computed Tomography angiography (CCTA). Existing methods struggle with challenges such as…

计算机视觉与模式识别 · 计算机科学 2025-04-29 Ni Yao , Xiangyu Liu , Danyang Sun , Chuang Han , Yanting Li , Jiaofen Nan , Chengyang Li , Fubao Zhu , Weihua Zhou , Chen Zhao

Coronary artery disease (CAD) is a leading cause of cardiovascular-related mortality, and accurate stenosis detection is crucial for effective clinical decision-making. Coronary angiography remains the gold standard for diagnosing CAD, but…

图像与视频处理 · 电气工程与系统科学 2025-03-25 Baixiang Huang , Yu Luo , Guangyu Wei , Songyan He , Yushuang Shao , Xueying Zeng

Diagnostic investigation has an important role in risk stratification and clinical decision making of patients with suspected and documented Coronary Artery Disease (CAD). However, the majority of existing tools are primarily focused on the…

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