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Correct measurement of the shell properties of coated microbubbles (MBs) is essential to understanding and optimizing their response to ultrasound (US) exposure parameters in diagnostic and therapeutic ultrasound. MBs are surrounded by…

A lipid coated bubble (LCB) oscillator is a very interesting non-smooth oscillator with many important applications ranging from industry and chemistry to medicine. However, due to the complex behavior of the coating intermixed with the…

流体动力学 · 物理学 2021-07-28 AJ Sojahrood , H. Haghi , T. M. Porter , R. Karshafian , M. C. Kolios

Monodisperse lipid-coated microbubbles are a promising route to unlock the full potential of ultrasound contrast agents for medical diagnosis and therapy. Here, we present a stand-alone lab-on-a-chip instrument that allows microbubbles to…

Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress in this…

流体动力学 · 物理学 2023-08-14 Marco Cattaneo , Outi Supponen

Understanding the pressure dependence of the nonlinear behavior of ultrasonically excited phospholipid (PL)-stabilized NBs is important for optimizing US exposure parameters for implementations of contrast enhanced ultrasound, critical to…

The problem of attenuation and sound speed of bubbly media has remained partially unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation and sound speed of a bubbly medium are not available. Our theoretical…

流体动力学 · 物理学 2022-09-20 AJ. Sojahrood , Q. Li , H. Haghi , R. Karshafian , T. M. Porter , M. C. Kolios

A way forward for high throughput fabrication of microcapsules with uniform size and mechanical properties was reported irrespective of the kinetic process of shell assembly. Microcapsules were produced using lab-scale emulsification…

软凝聚态物质 · 物理学 2021-02-12 Mehdi Maleki , Clément de Loubens , Kaili Xie , Emeline Talansier , Hugues Bodiguel , Marc Leonetti

Ultrasound is increasingly being used to modulate the properties of biological membranes for applications in drug delivery and neuromodulation. While various studies have investigated the mechanical aspect of the interaction such as…

软凝聚态物质 · 物理学 2018-11-19 Shamit Shrivastava , Robin O. Cleveland , Matthias F. Schneider

We demonstrate that the permeability of the cell wall of microalga $\textit{C. reinhardtii}$ can be enhanced in controlled microstreaming flow conditions using single bubbles adherent to a wall and driven by ultrasound near their resonance…

定量方法 · 定量生物学 2021-12-20 Angelo Pommella , Irina Harun , Klaus Hellgardt , Valeria Garbin

Sensors based on whispering gallery resonators have minute footprints and can push achievable sensitivities and resolutions to their limits. Here, we use a microbubble resonator, with a wall thickness of 500 nm and an intrinsic Q-factor of…

光学 · 物理学 2016-01-08 Yong Yang , Sunny Saurabh , Jonathan M Ward , Síle Nic Chormaic

Colloidal gels possess a memory of previous shear events, both steady and oscillatory. This memory, embedded in the microstructure, affects the mechanical response of the gel, and therefore enables precise tuning of the material properties…

软凝聚态物质 · 物理学 2022-03-10 Brice Saint-Michel , George Petekidis , Valeria Garbin

We present a computational study of the behaviour of a lipid-coated SonoVue microbubble with initial radius $1 \, \mu \text{m} \leq R_0 \leq 2 \, \mu \text{m}$, excited at frequencies (200-1500 kHz) significantly below the linear resonance…

流体动力学 · 物理学 2022-01-17 Jonas Gümmer , Sören Schenke , Fabian Denner

The mechanical properties of cells play key roles in their physiology, function, physiological and pathological transformations. Micro-elastography has recently emerged as a promising tool to estimate cellular viscoelastic properties within…

A variety of numerical methods exist for the study of deformable particles in dense suspensions. None of the standard tools, however, currently include volume-changing objects such as oscillating microbubbles in three-dimensional periodic…

生物物理 · 物理学 2017-08-14 Achim Guckenberger , Stephan Gekle

This review describes the analytical calculation of lateral pressure profile in lipid membrane with finite curvature. The derivation is based on the previously developed microscopic model of flexible strings [1,2]. According to this theory…

软凝聚态物质 · 物理学 2016-07-08 Anna A. Drozdova

Exploiting the full potential of MBs for applications requires a good understanding of their complex dynamics. Improved understanding of MB oscillations can lead to further enhancement in optimizing their efficacy in many applications and…

应用物理 · 物理学 2019-02-06 H. Haghi , AJ Sojahrood , M. C. Kolios

Locally (re)structuring colloidal gels $\unicode{x2013}$ micron-sized particles forming a connected network with arrested dynamics $\unicode{x2013}$ enables precise tuning of the micromechanical and -rheological properties of the system. A…

软凝聚态物质 · 物理学 2022-11-07 Kim William Torre , Joost de Graaf

The tunability of an optical cavity is an essential requirement for many areas of research. Here, we use the Pound-Drever-Hall technique to lock a laser to a whispering gallery mode (WGM) of a microbubble resonator, to show that linear…

光学 · 物理学 2016-05-04 Ramgopal Madugani , Yong Yang , Vu H Le , Jonathan M. Ward , Síle Nic Chormaic

Results of the measurements of sound speed and attenuation in a bubbly medium are reported. Monodisperse bubble solutions are sonicated with broadband ultrasound pulses with pressure amplitudes ranging between 12.5-100 kPa. Fundamental…

流体动力学 · 物理学 2018-11-20 A. J. Sojahrood , Q. Li , H. Haghi , R. Karshafian , T. M. Porter , M. C. Kolios

Contrast-enhanced ultrasound (CEUS) presents distinct advantages in diagnostic echography. Utilizing microbubbles (MBs) as conventional contrast agents enhances vascular visualization and organ perfusion, facilitating real-time,…

医学物理 · 物理学 2024-12-04 Agisilaos Matalliotakis , Martin D. Verweij
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