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Two major challenges in time-of-flight positron emission tomography (TOF-PET) are low spatial resolution and high radioactive dose to the patient, both of which result from limitations in detection technology rather than fundamental…

We have used the TOPAS simulation framework to model the direct conversion of 511 keV gamma rays to electrons in a micro-channel plate (MCP) constructed from thin laminae of a heavy-metal-loaded dielectric such as lead-glass, patterned with…

高能物理 - 实验 · 物理学 2023-10-03 Kepler Domurat-Sousa , Cameron Poe , Henry J. Frisch , Bernhard W. Adams , Camden Ertley , Neal Sullivan

In positron emission tomography (PET), time-of-flight (TOF) information localizes source positions along lines of response. Cherenkov-radiator-integrated microchannel-plate photomultiplier tubes have achieved 30 ps TOF resolution,…

We have used the TOPAS Geant4-based package to create a parametric simulation of a new TOF-PET scanner design based on a low atomic number scintillator. TOPAS was extended to provide complete information on individual particle position,…

医学物理 · 物理学 2023-10-03 Kepler Domurat-Sousa , Cameron Poe

Time-Of-Flight (TOF) is a noble technique that is used in Positron Emission Tomography (PET) imaging worldwide. The scintillator based imaging system that is being used around the world for TOF-PET is very expensive. Multi-gap Resistive…

The purpose of this study was to show how advanced concepts of compact, lossless and "Time Of Flight" (TOF) capable electronics similar to those foreseen for the LHC and ILC experiments could be fairly and easily transferred to the medical…

仪器与探测器 · 物理学 2009-08-03 P. -E. Vert , J. Lecoq , G. Montarou , N. Pauna , B. Joly , M. Boutemeur , H. Mathez , R. Gaglione , P. Le Dû

Intraoperative Gamma Probe (IPG) remains the current gold standard modality for sentinel lymph node identification and tumor removal in cancer patients. However, even alongside the optical dyes they do not meet with <5% false negative rates…

医学物理 · 物理学 2022-01-26 S. Sajedi , L. Blackberg , S. Majewski , H. Sabet

Single-bed whole-body positron emission tomography based on resistive plate chamber detectors (RPC-PET) has been proposed for human studies, as a complementary resource to scintillator-based PET scanners. The purpose of this work is mainly…

The low cost and high resolution gas-based Multi-gap Resistive Plate Chamber (MRPC) opens a new possibility to find an efficient alternative detector for Time of Flight (TOF) based Positron Emission Tomography, where the sensitivity of the…

仪器与探测器 · 物理学 2011-06-30 A. Banerjee , S. Chattopadhyay

Improving the coincidence time resolution (CTR) of time-of-flight positron emission tomography (TOF-PET) systems to achieve a higher signal-to-noise ratio (SNR) gain or even direct positron emission imaging (dPEI) is of paramount importance…

We propose PET scanners using low atomic number media that undergo a persistent local change of state along the paths of the Compton recoil electrons. Measurement of the individual scattering locations and angles, deposited energies, and…

In this study we address the feasibility and main properties of a positron emission tomograph (PET) based on RPCs. The concept, making use of the converter-plate principle, takes advantage of the intrinsic layered structure of RPCs and its…

仪器与探测器 · 物理学 2009-11-07 A. Blanco , V. Chepel , R. Ferreira-Marques , P. Fonte , M. I. Lopes , V. Peskov , A. Policarpo

In this work, we present modeling and imaging performance of a dual panel limited-angle TOF-PET system for intraoperative surgical applications using GATE monte carlo toolkit. Several detector parameters such as detector pixel dimensions,…

医学物理 · 物理学 2024-02-13 Salar Sajedi , Yuemeng Feng , Hamid Sabet

This master thesis presents a new type of Positron Emission TOF Apparatus using Liquid xenOn (PETALO). The detector is based in the Liquid Xenon Scintillating Cell (LXSC). The cell is a box filled with liquid xenon (LXe) whose transverse…

医学物理 · 物理学 2016-06-01 J. M. Benlloch-Rodriguez

The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment…

Positron Emission Tomography (PET) imaging requires accurate attenuation correction (AC) to account for photon loss due to tissue density variations. In PET/MR systems, computed tomography (CT), which offers a straightforward estimation of…

图像与视频处理 · 电气工程与系统科学 2025-04-11 Weijie Chen , James Wang , Alan McMillan

PET is a functional imaging technique based on detection of annihilation photons following beta decay producing positrons. In this paper, we present the concept of a new PET system for preclinical applications consisting of a ring of twelve…

Objective: Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes…

图像与视频处理 · 电气工程与系统科学 2024-04-18 Shaoyan Pan , Elham Abouei , Junbo Peng , Joshua Qian , Jacob F Wynne , Tonghe Wang , Chih-Wei Chang , Justin Roper , Jonathon A Nye , Hui Mao , Xiaofeng Yang

Positron emission tomography (PET) is an advanced medical imaging technique that plays a crucial role in non-invasive clinical diagnosis. However, while reducing radiation exposure through low-dose PET scans is beneficial for patient…

计算机视觉与模式识别 · 计算机科学 2024-07-02 Bin Huang , Xubiao Liu , Lei Fang , Qiegen Liu , Bingxuan Li

Positron Emission Tomography (PET) is an important molecular imaging tool widely used in medicine. Traditional PET systems rely on complete detector rings for full angular coverage and reliable data collection. However, incomplete-ring PET…

计算机视觉与模式识别 · 计算机科学 2026-05-26 Yeqi Fang , Rong Zhou
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