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Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

计算机视觉与模式识别 · 计算机科学 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only…

机器学习 · 计算机科学 2022-12-20 Wei Tang , Weijia Zhang , Min-Ling Zhang

While multiple instance learning (MIL) has shown to be a promising approach for histopathological whole slide image (WSI) analysis, its reliance on permutation invariance significantly limits its capacity to effectively uncover semantic…

图像与视频处理 · 电气工程与系统科学 2025-07-14 Xiwen Chen , Peijie Qiu , Wenhui Zhu , Hao Wang , Huayu Li , Xuanzhao Dong , Xiaotong Sun , Xiaobing Yu , Yalin Wang , Abolfazl Razi , Aristeidis Sotiras

Mammograms are commonly employed in the large scale screening of breast cancer which is primarily characterized by the presence of malignant masses. However, automated image-level detection of malignancy is a challenging task given the…

计算机视觉与模式识别 · 计算机科学 2020-04-27 Sarath Chandra K , Arunava Chakravarty , Nirmalya Ghosh , Tandra Sarkar , Ramanathan Sethuraman , Debdoot Sheet

Breast cancer is the most prevalent cancer in women worldwide. Histopathology image analysis serves as the gold standard for cancer diagnosis. In this regard, whole-slide imaging (WSI), a revolutionary technology in digital pathology,…

统计方法学 · 统计学 2026-04-21 Baichen Yu , Xuetong Li , Jing Zhou , Hansheng Wang

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution…

计算机视觉与模式识别 · 计算机科学 2025-03-04 Xitong Ling , Yifeng Ping , Jiawen Li , Jing Peng , Yuxuan Chen , Minxi Ouyang , Yizhi Wang , Yonghong He , Tian Guan , Xiaoping Liu , Lianghui Zhu

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

定量方法 · 定量生物学 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

The quantity and the quality of the training labels are central problems in high-resolution land-cover mapping with machine-learning-based solutions. In this context, weak labels can be gathered in large quantities by leveraging on existing…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Gianmarco Perantoni , Lorenzo Bruzzone

Single-positive multi-label learning (SPMLL) is a typical weakly supervised multi-label learning problem, where each training example is annotated with only one positive label. Existing SPMLL methods typically assign pseudo-labels to…

机器学习 · 计算机科学 2024-05-28 Biao Liu , Ning Xu , Jie Wang , Xin Geng

This document describes a novel learning algorithm that classifies "bags" of instances rather than individual instances. A bag is labeled positive if it contains at least one positive instance (which may or may not be specifically…

机器学习 · 计算机科学 2014-07-11 Ramasubramanian Sundararajan , Hima Patel , Manisha Srivastava

Novelty detection plays an important role in machine learning and signal processing. This paper studies novelty detection in a new setting where the data object is represented as a bag of instances and associated with multiple class labels,…

机器学习 · 计算机科学 2013-12-02 Qi Lou , Raviv Raich , Forrest Briggs , Xiaoli Z. Fern

Multiple instance learning (MIL) has been successfully applied for whole slide images (WSIs) analysis in computational pathology, enabling a wide range of prediction tasks from tumor subtyping to inferring genetic mutations and multi-omics…

计算机视觉与模式识别 · 计算机科学 2024-07-25 Junyu Li , Ye Zhang , Wen Shu , Xiaobing Feng , Yingchun Wang , Pengju Yan , Xiaolin Li , Chulin Sha , Min He

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

计算机视觉与模式识别 · 计算机科学 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

Multilabel classification is a relatively recent subfield of machine learning. Unlike to the classical approach, where instances are labeled with only one category, in multilabel classification, an arbitrary number of categories is chosen…

人工智能 · 计算机科学 2013-03-01 Alfonso E. Romero , Luis M. de Campos

Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

计算机视觉与模式识别 · 计算机科学 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Multiple instance learning (MIL) has been extensively applied to whole slide histopathology image (WSI) analysis. The existing aggregation strategy in MIL, which primarily relies on the first-order distance (e.g., mean difference) between…

计算机视觉与模式识别 · 计算机科学 2024-07-22 Yihang Chen , Tsai Hor Chan , Guosheng Yin , Yuming Jiang , Lequan Yu

In many real-world tasks, the concerned objects can be represented as a multi-instance bag associated with a candidate label set, which consists of one ground-truth label and several false positive labels. Multi-instance partial-label…

机器学习 · 计算机科学 2023-09-29 Wei Tang , Weijia Zhang , Min-Ling Zhang

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

计算机视觉与模式识别 · 计算机科学 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Uncertainty estimation (UE), as an effective means of quantifying predictive uncertainty, is crucial for safe and reliable decision-making, especially in high-risk scenarios. Existing UE schemes usually assume that there are…

机器学习 · 计算机科学 2024-05-10 Pei Liu , Luping Ji

Immune repertoire classification, a typical multiple instance learning (MIL) problem, is a frontier research topic in computational biology that makes transformative contributions to new vaccines and immune therapies. However, the…

机器学习 · 计算机科学 2023-08-01 Mingcai Chen , Yu Zhao , Zhonghuang Wang , Bing He , Jianhua Yao
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