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Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

图像与视频处理 · 电气工程与系统科学 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Survival prediction using whole slide images (WSIs) can be formulated as a multiple instance learning (MIL) problem. However, existing MIL methods often fail to explicitly capture pathological heterogeneity within WSIs, both globally --…

计算机视觉与模式识别 · 计算机科学 2025-06-30 Qin Ren , Yifan Wang , Ruogu Fang , Haibin Ling , Chenyu You

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is particularly challenging due to the different nature of…

计算机视觉与模式识别 · 计算机科学 2024-04-16 Guillaume Jaume , Anurag Vaidya , Richard Chen , Drew Williamson , Paul Liang , Faisal Mahmood

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently…

计算机视觉与模式识别 · 计算机科学 2023-11-21 Mingxin Liu , Yunzan Liu , Hui Cui , Chunquan Li , Jiquan Ma

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

计算机视觉与模式识别 · 计算机科学 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

Few-Shot Remote Sensing Scene Classification (FS-RSSC) presents the challenge of classifying remote sensing images with limited labeled samples. Existing methods typically emphasize single-modal feature learning, neglecting the potential…

计算机视觉与模式识别 · 计算机科学 2025-03-20 Zhong Ji , Ci Liu , Jingren Liu , Chen Tang , Yanwei Pang , Xuelong Li

Survival outcome assessment is challenging and inherently associated with multiple clinical factors (e.g., imaging and genomics biomarkers) in cancer. Enabling multimodal analytics promises to reveal novel predictive patterns of patient…

计算机视觉与模式识别 · 计算机科学 2023-07-25 Kexin Ding , Mu Zhou , Dimitris N. Metaxas , Shaoting Zhang

Transformer has been widely used in histopathology whole slide image (WSI) classification for the purpose of tumor grading, prognosis analysis, etc. However, the design of token-wise self-attention and positional embedding strategy in the…

计算机视觉与模式识别 · 计算机科学 2022-06-28 Yushan Zheng , Jun Li , Jun Shi , Fengying Xie , Zhiguo Jiang

This thesis examines self-attention training through the lens of Optimal Transport (OT) and develops an OT-based alternative for tabular classification. The study tracks intermediate projections of the self-attention layer during training…

机器学习 · 统计学 2026-02-19 Alessandro Quadrio , Antonio Candelieri

The optimal transport (OT) map offers the most economical way to transfer one probability measure distribution to another. Classical OT theory does not involve a discussion of preserving topological connections and orientations in…

一般拓扑 · 数学 2025-07-03 Yuping Lv , Qi Zhao , Xuebin Chang , Wei Zeng

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance…

计算机视觉与模式识别 · 计算机科学 2024-10-21 Honglin Li , Yunlong Zhang , Pingyi Chen , Zhongyi Shui , Chenglu Zhu , Lin Yang

Multimodal pathology-genomic analysis is critical for cancer survival prediction. However, existing approaches predominantly integrate formalin-fixed paraffin-embedded (FFPE) slides with genomic data, while neglecting the availability of…

计算机视觉与模式识别 · 计算机科学 2025-06-25 Mingcheng Qu , Guang Yang , Donglin Di , Yue Gao , Tonghua Su , Yang Song , Lei Fan

Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for portal hypertension, but provides variable survival outcomes and frequent overt hepatic encephalopathy (OHE), indicating the necessity of accurate…

计算机视觉与模式识别 · 计算机科学 2025-10-14 Junhao Dong , Dejia Liu , Ruiqi Ding , Zongxing Chen , Yingjie Huang , Zhu Meng , Jianbo Zhao , Zhicheng Zhao , Fei Su

Optimal transport (OT) is a powerful geometric and probabilistic tool for finding correspondences and measuring similarity between two distributions. Yet, its original formulation relies on the existence of a cost function between the…

机器学习 · 统计学 2020-11-09 Ievgen Redko , Titouan Vayer , Rémi Flamary , Nicolas Courty

Optimal transport (OT) is a widely used technique for distribution alignment, with applications throughout the machine learning, graphics, and vision communities. Without any additional structural assumptions on trans-port, however, OT can…

机器学习 · 计算机科学 2021-07-20 Chi-Heng Lin , Mehdi Azabou , Eva L. Dyer

Multimodal machine learning integrating histopathology and molecular data shows promise for cancer prognostication. We systematically reviewed studies combining whole slide images (WSIs) and high-throughput omics to predict overall…

定量方法 · 定量生物学 2025-07-30 Charlotte Jennings , Andrew Broad , Lucy Godson , Emily Clarke , David Westhead , Darren Treanor

Multimodal survival methods combining gigapixel histology whole-slide images (WSIs) and transcriptomic profiles are particularly promising for patient prognostication and stratification. Current approaches involve tokenizing the WSIs into…

计算机视觉与模式识别 · 计算机科学 2024-07-02 Andrew H. Song , Richard J. Chen , Guillaume Jaume , Anurag J. Vaidya , Alexander S. Baras , Faisal Mahmood

Optimal transport (OT) is a widely used technique in machine learning, graphics, and vision that aligns two distributions or datasets using their relative geometry. In symmetry-rich settings, however, OT alignments based solely on pairwise…

机器学习 · 计算机科学 2025-09-26 Annabel Ma , Kaiying Hou , David Alvarez-Melis , Melanie Weber

The objective in statistical Optimal Transport (OT) is to consistently estimate the optimal transport plan/map solely using samples from the given source and target marginal distributions. This work takes the novel approach of posing…

机器学习 · 计算机科学 2020-11-11 J. Saketha Nath , Pratik Jawanpuria

Optimal transport (OT) compares probability distributions by computing a meaningful alignment between their samples. CO-optimal transport (COOT) takes this comparison further by inferring an alignment between features as well. While this…

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