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In histopathology, tissue samples are often larger than a standard microscope slide, making stitching of multiple fragments necessary to process entire structures such as tumors. Automated stitching is a prerequisite for scaling analysis,…

The ability of tumors to evolve and adapt by developing subclones in different genetic and epigenetic states is a major challenge in oncology. Traditional tools like multi-regional sequencing used to study tumor evolution and the resultant…

Multimodal pathological image understanding has garnered widespread interest due to its potential to improve diagnostic accuracy and enable personalized treatment through integrated visual and textual data. However, existing methods exhibit…

计算机视觉与模式识别 · 计算机科学 2025-05-22 Zhe Xu , Cheng Jin , Yihui Wang , Ziyi Liu , Hao Chen

Today, we are seeing an ever-increasing number of clinical notes that contain clinical results, images, and textual descriptions of patient's health state. All these data can be analyzed and employed to cater novel services that can help…

计算与语言 · 计算机科学 2021-06-10 Danilo Dessi , Rim Helaoui , Vivek Kumar , Diego Reforgiato Recupero , Daniele Riboni

Many real-world applications require aligning two temporal sequences, including bioinformatics, handwriting recognition, activity recognition, and human-robot coordination. Dynamic Time Warping (DTW) is a popular alignment method, but can…

机器学习 · 计算机科学 2021-09-21 Sridhar Mahadevan , Anup Rao , Georgios Theocharous , Jennifer Healey

Survival analysis using whole-slide images (WSIs) is crucial in cancer research. Despite significant successes, pathology images typically only provide slide-level labels, which hinders the learning of discriminative representations from…

计算机视觉与模式识别 · 计算机科学 2025-09-23 Chengsheng Zhang , Linhao Qu , Xiaoyu Liu , Zhijian Song

Multimodal variational autoencoders (VAEs) aim to capture shared latent representations by integrating information from different data modalities. A significant challenge is accurately inferring representations from any subset of modalities…

机器学习 · 计算机科学 2024-10-16 Yuta Oshima , Masahiro Suzuki , Yutaka Matsuo

Whole Slide Images (WSI), obtained by high-resolution digital scanning of microscope slides at multiple scales, are the cornerstone of modern Digital Pathology. However, they represent a particular challenge to AI-based/AI-mediated analysis…

计算机视觉与模式识别 · 计算机科学 2024-04-12 Martim Afonso , Praphulla M. S. Bhawsar , Monjoy Saha , Jonas S. Almeida , Arlindo L. Oliveira

High-fidelity registration of histopathological whole slide images (WSIs), such as hematoxylin & eosin (H&E) and immunohistochemistry (IHC), is vital for integrated molecular analysis but challenging to evaluate without ground-truth (GT)…

计算机视觉与模式识别 · 计算机科学 2026-02-05 Shikha Dubey , Patricia Raciti , Kristopher Standish , Albert Juan Ramon , Erik Ames Burlingame

Different medical imaging modalities capture diagnostic information at varying spatial resolutions, from coarse global patterns to fine-grained localized structures. However, most existing vision-language frameworks in the medical domain…

计算机视觉与模式识别 · 计算机科学 2025-06-12 Shivang Chopra , Gabriela Sanchez-Rodriguez , Lingchao Mao , Andrew J Feola , Jing Li , Zsolt Kira

In extreme scenarios such as nighttime or low-visibility environments, achieving reliable perception is critical for applications like autonomous driving, robotics, and surveillance. Multi-modality image fusion, particularly integrating…

计算机视觉与模式识别 · 计算机科学 2025-05-27 Yuchen Guo , Ruoxiang Xu , Rongcheng Li , Weifeng Su

Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies…

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

计算机视觉与模式识别 · 计算机科学 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker as it is a measure for tumor cell proliferation. However, the identification of MFs has a known low inter-rater…

Multimodal medical image fusion (MMIF) extracts the most meaningful information from multiple source images, enabling a more comprehensive and accurate diagnosis. Achieving high-quality fusion results requires a careful balance of…

计算机视觉与模式识别 · 计算机科学 2025-06-19 Dan He , Weisheng Li , Guofen Wang , Yuping Huang , Shiqiang Liu

The segmentation of histopathological whole slide images into tumourous and non-tumourous types of tissue is a challenging task that requires the consideration of both local and global spatial contexts to classify tumourous regions…

The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…

图像与视频处理 · 电气工程与系统科学 2024-09-27 Ardhendu Sekhar , Vrinda Goel , Garima Jain , Abhijeet Patil , Ravi Kant Gupta , Tripti Bameta , Swapnil Rane , Amit Sethi

The combination of electronic health records (EHR) and medical images is crucial for clinicians in making diagnoses and forecasting prognosis. Strategically fusing these two data modalities has great potential to improve the accuracy of…

图像与视频处理 · 电气工程与系统科学 2024-10-24 Wenfang Yao , Kejing Yin , William K. Cheung , Jia Liu , Jing Qin

Major depressive disorder (MDD) is a common neuropsychiatric condition whose accurate diagnosis from resting-state functional magnetic resonance imaging (rs-fMRI) remains difficult. Dynamic functional connectivity (DFC) captures…

计算机视觉与模式识别 · 计算机科学 2026-05-26 Muhammad Asif Hasan , Yanming Zhu , Xuefei Yin , Alan Wee-Chung Liew

The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. However, most prognostic models are either based on histology or…

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