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Machine learning (ML) has been playing important roles in drug discovery in the past years by providing (pre-)screening tools for prioritising chemical compounds to pass through wet lab experiments. One of the main ML tasks in drug…

生物大分子 · 定量生物学 2025-02-25 Alex G. C. de Sá , David B. Ascher

Large Language Models (LLMs) have achieved remarkable capabilities, yet their improvement methods remain fundamentally constrained by human design. We present Self-Developing, a framework that enables LLMs to autonomously discover,…

计算与语言 · 计算机科学 2025-06-11 Yoichi Ishibashi , Taro Yano , Masafumi Oyamada

Large Language Models (LLMs) have demonstrated superior results across a wide range of tasks, and Retrieval-augmented Generation (RAG) is an effective way to enhance the performance by locating relevant information and placing it into the…

计算与语言 · 计算机科学 2024-02-22 Zixuan Ke , Weize Kong , Cheng Li , Mingyang Zhang , Qiaozhu Mei , Michael Bendersky

Recent advances in large language models (LLMs) have made significant progress across multiple biomedical tasks, including biomedical question answering, lay-language summarization of the biomedical literature, and clinical note…

信息检索 · 计算机科学 2026-03-24 Deepak Gupta , Dina Demner-Fushman , William Hersh , Steven Bedrick , Kirk Roberts

This paper presents an approach to lemma synthesis to support advanced inductive entailment procedures based on separation logic. We first propose a mechanism where lemmas are automatically proven and systematically applied. The lemmas may…

编程语言 · 计算机科学 2018-05-15 Quang Loc Le

In this paper, we consider the problem of automatic modulation classification with multiple sensors in the presence of unknown time offset, phase offset and received signal amplitude. We develop a novel hybrid maximum likelihood (HML)…

其他计算机科学 · 计算机科学 2015-02-05 O. Ozdemir , T. Wimalajeewa , B. Dulek , P. K. Varshney , W. Su

To perform effective causal inference in high-dimensional datasets, initiating the process with causal discovery is imperative, wherein a causal graph is generated based on observational data. However, obtaining a complete and accurate…

机器学习 · 计算机科学 2025-04-18 Elahe Khatibi , Mahyar Abbasian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

Diabetes mellitus is a chronic metabolic disorder that has emerged as one of the major health problems worldwide due to its high prevalence and serious complications, which are pricey to manage. Effective management requires good glycemic…

机器学习 · 计算机科学 2024-07-01 Abolfazl Zarghani

Due to the remarkable reasoning ability, Large language models (LLMs) have demonstrated impressive performance in knowledge graph question answering (KGQA) tasks, which find answers to natural language questions over knowledge graphs (KGs).…

计算与语言 · 计算机科学 2025-02-25 Xiao Long , Liansheng Zhuang , Aodi Li , Minghong Yao , Shafei Wang

Difficult decision-making problems abound in various disciplines and domains. The proliferation of generative techniques, especially large language models (LLMs), has excited interest in using them for decision support. However, LLMs cannot…

人工智能 · 计算机科学 2025-09-16 Boris Kovalerchuk , Brent D. Fegley

In the current deep learning based recommendation system, the embedding method is generally employed to complete the conversion from the high-dimensional sparse feature vector to the low-dimensional dense feature vector. However, as the…

信息检索 · 计算机科学 2021-08-10 Huimin Zhou , Qing Li , Yong Jiang , Rongwei Yang , Zhuyun Qi

Scientific discovery plays a pivotal role in advancing human society, and recent progress in large language models (LLMs) suggests their potential to accelerate this process. However, it remains unclear whether LLMs can autonomously…

计算与语言 · 计算机科学 2025-10-28 Zonglin Yang , Wanhao Liu , Ben Gao , Tong Xie , Yuqiang Li , Wanli Ouyang , Soujanya Poria , Erik Cambria , Dongzhan Zhou

LLM pre-training efficacy increasingly depends on data composition rather than sheer volume. Yet, optimal mixing is hindered by categorization flaws: human taxonomies suffer from ontological misalignment, and Euclidean clustering fails to…

机器学习 · 计算机科学 2026-05-27 Yue Min , Ziyun Qiao , Ruining Chen , Yujun Li

Retrieval Augmented Generation or RAG is the most popular pattern for modern Large Language Model or LLM applications. RAG involves taking a user query and finding relevant paragraphs of context in a large corpus typically captured in a…

信息检索 · 计算机科学 2024-08-20 Dattaraj Rao

In genome-scale constraint-based metabolic models, gene deletion strategies are essential for achieving growth-coupled production, where cell growth and target metabolite synthesis occur simultaneously. Despite the inherently networked…

定量方法 · 定量生物学 2026-04-10 Ziwei Yang , Takeyuki Tamura

Ensembles of generative large language models (LLMs) are a promising way to compensate for individual model limitations, integrating the strengths of different LLMs. Existing LLM ensemble methods, however, face limitations such as…

计算与语言 · 计算机科学 2026-03-09 Bo Lv , Nayu Liu , Chen Tang , Xin Liu , Yue Yu , Ping Luo

Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

The material presented in this paper contributes to establishing a basis deemed essential for substantial progress in Automated Deduction. It identifies and studies global features in selected problems and their proofs which offer the…

人工智能 · 计算机科学 2021-07-14 Christoph Wernhard , Wolfgang Bibel

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Retrieval-Augmented Large Language Models (LLMs), which incorporate the non-parametric knowledge from external knowledge bases into LLMs, have emerged as a promising approach to enhancing response accuracy in several tasks, such as…

计算与语言 · 计算机科学 2024-03-29 Soyeong Jeong , Jinheon Baek , Sukmin Cho , Sung Ju Hwang , Jong C. Park