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Breast cancer is the most prevalent cancer in women worldwide. Histopathology image analysis serves as the gold standard for cancer diagnosis. In this regard, whole-slide imaging (WSI), a revolutionary technology in digital pathology,…

统计方法学 · 统计学 2026-04-21 Baichen Yu , Xuetong Li , Jing Zhou , Hansheng Wang

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The difference in procedures to acquire WSIs at various trial sites gives rise to variability in the histopathology images, thus making consistent…

图像与视频处理 · 电气工程与系统科学 2022-04-07 Milad Sikaroudi , Shahryar Rahnamayan , H. R. Tizhoosh

Convolutional neural networks (CNNs) have been recently used for a variety of histology image analysis. However, availability of a large dataset is a major prerequisite for training a CNN which limits its use by the computational pathology…

计算机视觉与模式识别 · 计算机科学 2018-03-07 Ruqayya Awan , Navid Alemi Koohbanani , Muhammad Shaban , Anna Lisowska , Nasir Rajpoot

Whole slide image (WSI) has been widely used to assist automated diagnosis under the deep learning fields. However, most previous works only discuss the SINGLE task setting which is not aligned with real clinical setting, where pathologists…

计算机视觉与模式识别 · 计算机科学 2023-03-31 Weiqin Zhao , Shujun Wang , Maximus Yeung , Tianye Niu , Lequan Yu

Whole-slide image (WSI) classification is a challenging task because 1) patches from WSI lack annotation, and 2) WSI possesses unnecessary variability, e.g., stain protocol. Recently, Multiple-Instance Learning (MIL) has made significant…

计算机视觉与模式识别 · 计算机科学 2025-08-12 Joohyung Lee , Heejeong Nam , Kwanhyung Lee , Sangchul Hahn

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

计算机视觉与模式识别 · 计算机科学 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Whole Slide Imaging (WSI), which involves high-resolution digital scans of pathology slides, has become the gold standard for cancer diagnosis, but its gigapixel resolution and the scarcity of annotated datasets present challenges for deep…

图像与视频处理 · 电气工程与系统科学 2025-02-03 Rita Pereira , M. Rita Verdelho , Catarina Barata , Carlos Santiago

Correct treatment of urothelial carcinoma patients is dependent on accurate grading and staging of the cancer tumour. This is determined manually by a pathologist by examining the histological whole-slide images (WSI). The large size of…

图像与视频处理 · 电气工程与系统科学 2019-09-12 Rune Wetteland , Kjersti Engan , Trygve Eftestøl , Vebjørn Kvikstad , Emilius A. M. Janssen

At the core of self-supervised learning for vision is the idea of learning invariant or equivariant representations with respect to a set of data transformations. This approach, however, introduces strong inductive biases, which can render…

机器学习 · 计算机科学 2024-05-29 Sharut Gupta , Chenyu Wang , Yifei Wang , Tommi Jaakkola , Stefanie Jegelka

Lifelong learning for whole slide images (WSIs) poses the challenge of training a unified model to perform multiple WSI-related tasks, such as cancer subtyping and tumor classification, in a distributed, continual fashion. This is a…

计算机视觉与模式识别 · 计算机科学 2025-04-23 Doanh C. Bui , Hoai Luan Pham , Vu Trung Duong Le , Tuan Hai Vu , Van Duy Tran , Yasuhiko Nakashima

Survival analysis based on Whole Slide Images (WSIs) is crucial for evaluating cancer prognosis, as they offer detailed microscopic information essential for predicting patient outcomes. However, traditional WSI-based survival analysis…

计算机视觉与模式识别 · 计算机科学 2025-09-22 Zheng Wang , Hong Liu , Zheng Wang , Danyi Li , Min Cen , Baptiste Magnier , Li Liang , Liansheng Wang

Diagnostic, prognostic and therapeutic decision-making of cancer in pathology clinics can now be carried out based on analysis of multi-gigapixel tissue images, also known as whole-slide images (WSIs). Recently, deep convolutional neural…

图像与视频处理 · 电气工程与系统科学 2022-09-08 Quoc Dang Vu , Kashif Rajpoot , Shan E Ahmed Raza , Nasir Rajpoot

Accurate nuclei segmentation in microscopy whole slide images (WSIs) remains challenging due to variability in staining, imaging conditions, and tissue morphology. We propose CellGenNet, a knowledge distillation framework for robust…

计算机视觉与模式识别 · 计算机科学 2025-11-20 Srijan Ray , Bikesh K. Nirala , Jason T. Yustein , Sundaresh Ram

Recent advancements in computational pathology have produced patch-level Multi-modal Large Language Models (MLLMs), but these models are limited by their inability to analyze whole slide images (WSIs) comprehensively and their tendency to…

计算机视觉与模式识别 · 计算机科学 2025-08-13 Yuci Liang , Xinheng Lyu , Wenting Chen , Meidan Ding , Jipeng Zhang , Xiangjian He , Song Wu , Xiaohan Xing , Sen Yang , Xiyue Wang , Linlin Shen

Using features extracted from networks pretrained on ImageNet is a common practice in applications of deep learning for digital pathology. However it presents the downside of missing domain specific image information. In digital pathology,…

计算机视觉与模式识别 · 计算机科学 2020-01-14 Jacob Gildenblat , Eldad Klaiman

Cancer remains one of the leading causes of mortality worldwide, necessitating accurate diagnosis and prognosis. Whole Slide Imaging (WSI) has become an integral part of clinical workflows with advancements in digital pathology. While…

图像与视频处理 · 电气工程与系统科学 2025-04-09 Ahmad Hussein , Mukesh Prasad , Ali Anaissi , Ali Braytee

Survival prediction based on whole slide images (WSIs) is a challenging task for patient-level multiple instance learning (MIL). Due to the vast amount of data for a patient (one or multiple gigapixels WSIs) and the irregularly shaped…

计算机视觉与模式识别 · 计算机科学 2023-07-03 Zhuchen Shao , Yang Chen , Hao Bian , Jian Zhang , Guojun Liu , Yongbing Zhang

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Yinsheng He , Xingyu Li

Automatic integration of whole slide images (WSIs) and gene expression profiles has demonstrated substantial potential in precision clinical diagnosis and cancer progression studies. However, most existing studies focus on individual gene…

计算机视觉与模式识别 · 计算机科学 2026-01-14 Junzhuo Liu , Xuemei Du , Daniel Reisenbuchler , Ye Chen , Markus Eckstein , Christian Matek , Friedrich Feuerhake , Dorit Merhof

Accurate cancer diagnosis remains a critical challenge in digital pathology, largely due to the gigapixel size and complex spatial relationships present in whole slide images. Traditional multiple instance learning (MIL) methods often…

计算机视觉与模式识别 · 计算机科学 2024-04-18 Kechun Liu , Wenjun Wu , Joann G. Elmore , Linda G. Shapiro