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Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation…

计算机视觉与模式识别 · 计算机科学 2019-07-31 Jayaraman J. Thiagarajan , Satyananda Kashyap , Alexandros Karagyris

In this paper, we propose a novel approach to tackle the multiple instance regression (MIR) problem. This problem arises when the data is a collection of bags, where each bag is made of multiple instances corresponding to the same unique…

机器学习 · 统计学 2020-03-13 Thomas Uriot

Multiple Instance Learning (MIL) has been widely applied in pathology towards solving critical problems such as automating cancer diagnosis and grading, predicting patient prognosis, and therapy response. Deploying these models in a…

计算机视觉与模式识别 · 计算机科学 2022-10-18 Syed Ashar Javed , Dinkar Juyal , Harshith Padigela , Amaro Taylor-Weiner , Limin Yu , Aaditya Prakash

Classical multiple instance learning (MIL) methods are often based on the identical and independent distributed assumption between instances, hence neglecting the potentially rich contextual information beyond individual entities. On the…

计算机视觉与模式识别 · 计算机科学 2022-06-20 Daniel Reisenbüchler , Sophia J. Wagner , Melanie Boxberg , Tingying Peng

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

计算机视觉与模式识别 · 计算机科学 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

机器学习 · 计算机科学 2022-10-06 Weijia Zhang , Xuanhui Zhang , Han-Wen Deng , Min-Ling Zhang

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

计算机视觉与模式识别 · 计算机科学 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

The dynamic environment of laboratories and clinics, with streams of data arriving on a daily basis, requires regular updates of trained machine learning models for consistent performance. Continual learning is supposed to help train models…

机器学习 · 计算机科学 2025-08-12 Zahra Ebrahimi , Raheleh Salehi , Nassir Navab , Carsten Marr , Ario Sadafi

Multiple instance learning (MIL) stands as a powerful approach in weakly supervised learning, regularly employed in histological whole slide image (WSI) classification for detecting tumorous lesions. However, existing mainstream MIL methods…

图像与视频处理 · 电气工程与系统科学 2024-07-08 Wenhui Zhu , Xiwen Chen , Peijie Qiu , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Whole slide image (WSI) classification is a fundamental task for the diagnosis and treatment of diseases; but, curation of accurate labels is time-consuming and limits the application of fully-supervised methods. To address this, multiple…

计算机视觉与模式识别 · 计算机科学 2022-07-25 Philip Chikontwe , Soo Jeong Nam , Heounjeong Go , Meejeong Kim , Hyun Jung Sung , Sang Hyun Park

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

计算机视觉与模式识别 · 计算机科学 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

In recent years, the integration of pre-trained foundational models with multiple instance learning (MIL) has improved diagnostic accuracy in computational pathology. However, existing MIL methods focus on optimizing feature extractors and…

计算机视觉与模式识别 · 计算机科学 2025-12-24 Le Feng , Li Xiao

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…

计算机视觉与模式识别 · 计算机科学 2026-05-19 Xiangyu Li , Ran Su

The quantity and the quality of the training labels are central problems in high-resolution land-cover mapping with machine-learning-based solutions. In this context, weak labels can be gathered in large quantities by leveraging on existing…

计算机视觉与模式识别 · 计算机科学 2025-10-09 Gianmarco Perantoni , Lorenzo Bruzzone

Lesion appearance is a crucial clue for medical providers to distinguish referable diabetic retinopathy (rDR) from non-referable DR. Most existing large-scale DR datasets contain only image-level labels rather than pixel-based annotations.…

图像与视频处理 · 电气工程与系统科学 2022-10-13 Wenhui Zhu , Peijie Qiu , Natasha Lepore , Oana M. Dumitrascu , Yalin Wang

Attention mechanisms are often used in deep neural networks for distantly supervised relation extraction (DS-RE) to distinguish valid from noisy instances. However, traditional 1-D vector attention models are insufficient for the learning…

计算与语言 · 计算机科学 2018-09-05 Jinhua Du , Jingguang Han , Andy Way , Dadong Wan

Multiple instance learning (MIL) problem is currently solved from either bag-classification or instance-classification perspective, both of which ignore important information contained in some instances and result in limited performance.…

计算机视觉与模式识别 · 计算机科学 2024-08-12 Yingfan Ma , Xiaoyuan Luo , Mingzhi Yuan , Xinrong Chen , Manning Wang

Attention-based multiple instance learning (MIL) has emerged as a powerful framework for whole slide image (WSI) diagnosis, leveraging attention to aggregate instance-level features into bag-level predictions. Despite this success, we find…

计算机视觉与模式识别 · 计算机科学 2026-03-10 Linfeng Ye , Shayan Mohajer Hamidi , Zhixiang Chi , Guang Li , Mert Pilanci , Takahiro Ogawa , Miki Haseyama , Konstantinos N. Plataniotis

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

计算机视觉与模式识别 · 计算机科学 2023-12-22 Wenhao Tang , Sheng Huang , Xiaoxian Zhang , Fengtao Zhou , Yi Zhang , Bo Liu

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

计算机视觉与模式识别 · 计算机科学 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri