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Optical spectroscopy and imaging of microscopic samples have opened up a wide range of applications throughout the physical, chemical, and biological sciences. High chemical specificity may be achieved by directly interrogating the…

Chemical imaging enabled by Raman processes is crucial to investigating biological and chemical samples in a label-free manner. Stimulated Raman spectroscopy (SRS) overcomes the key limitation associated with low signal levels in…

光学 · 物理学 2026-03-25 Florian M. Schweizer , Hannah Terrasa , Manish Garg

Coherent Raman microscopy provide label-free imaging by interrogating the intrinsic vibration of biomolecules. Nevertheless, trade-off between high chemical-specificity and high imaging-speed currently exists in transition from spectroscopy…

光学 · 物理学 2017-10-11 Kun Chen , Tao Wu , Tao Chen , Tian Zhou , Haoyun Wei , Yan Li

Single-shot time resolved Coherent Anti-Stokes Raman Scattering (CARS) is presented as a viable method for fast measurements of molecular spectra. The method is based on the short spatial extension of femtosecond pulses and maps time delays…

光学 · 物理学 2009-11-13 Yuri Paskover , I. Sh. Averbukh , Yehiam Prior

Broadband coherent anti-Stokes Raman scattering (CARS) spectroscopy plays a vital role in chemical sensing and label-free vibrational imaging, yet conventional methods suffer from limited acquisition speeds and complex detection schemes.…

光学 · 物理学 2025-07-23 Jing Hu , Tianjian Lv , Zhaoyang Wen , Wending Huang , Ming Yan , Heping Zeng

We have developed an interferometric implementation of coherent anti-Stokes Raman scattering (CARS) which enables broadband coherent Raman spectroscopy free from non-resonant background (NRB), with a signal strength proportional to…

光学 · 物理学 2014-02-25 Brad Littleton , Thomas Kavanagh , Frederic Festy , David Richards

Since its first demonstration in the sixties, coherent anti-Stokes Raman scattering (CARS) has become a powerful spectroscopic sensing tool with broad applications in biology and chemistry. However, it is a complex nonlinear optical process…

光学 · 物理学 2020-07-15 Gombojav O. Ariunbold , Supriya Nagpal , Bryan Semon

Coherent anti-Stokes Raman scattering (CARS) and, in particular, femtosecond adaptive spectroscopic techniques (FAST CARS) have been successfully used for molecular spectroscopy and microscopic imaging. Recent progress in ultrafast…

We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique…

Coherent Anti Stokes Raman Scattering (CARS) offers many advantages for nonlinear bio-imaging, thanks to its sub-cellular spatial resolution and unique chemical specificity. Its working principle requires two incident pulsed laser beams…

光学 · 物理学 2020-08-19 Matthias Hofer , Siddarth Shivkumar , Bilal El Waly , Sophie Brasselet

We present super-resolved coherent anti-Stokes Raman scattering (CARS) microscopy by implementing phase-resolved image scanning microscopy (ISM), achieving up to two-fold resolution increase as compared with a conventional CARS microscope.…

光学 · 物理学 2024-11-22 Anna Zhitnitsky , Elad Benjamin , Ora Bitton , Dan Oron

Frequency modulation coherent anti-Stokes Raman scattering (FM CARS) is presented, using a compact as well as fast and widely tunable fiber-based light source. With this light source Raman resonances between 700 cm$^{-1}$ and 3200 cm$^{-1}$…

Coherent anti-Stokes Raman scattering (CARS) microspectroscopy has demonstrated significant potential for biological and materials imaging. To date, however, the primary mechanism of disseminating CARS spectroscopic information is through…

光学 · 物理学 2015-10-08 Charles H. Camp , Young Jong Lee , Marcus T. Cicerone

We demonstrate coherent anti-Stokes Raman scattering (CARS) microscopy with 1089 foci, enabled by a high repetition rate amplified oscillator and optical parametric amplifier. We employ a camera as multichannel detector to acquire and…

光学 · 物理学 2024-08-27 Dominykas Gudavicius , Lukas Kontenis , Wolfgang Langbein

We propose a new technique for comparing two Raman active samples. The method employs optical interference of the signals generated via coherent anti-Stokes Raman scattering (CARS) of broadband laser pulses with noisy spectra. It does not…

量子物理 · 物理学 2015-05-27 Evgeny A. Shapiro , Stanislav O. Konorov , Valery Milner

A new interferometric technique is demonstrated for measuring Coherent Anti-Stokes Raman Scattering (CARS) signals. Two forward-directed CARS signals are generated, one in each arm of an interferometer. The deterministic nature of the CARS…

光学 · 物理学 2007-05-23 J. S. Bredfeldt , D. L. Marks , C. Vinegoni , S. Hambir , S. A. Boppart

Dual-comb spectroscopy allows for the rapid, multiplexed acquisition of high-resolution spectra without the need for moving parts or low-resolution dispersive optics. This method of broadband spectroscopy is most often accomplished via…

Raman scattering spectroscopy is widely used as an analytical technique in various fields, but its measurement process tends to be slow due to the low scattering cross-section. In the last decade, various broadband coherent Raman scattering…

光学 · 物理学 2025-05-06 Takuma Nakamura , Kazuki Hashimoto , Takuro Ideguchi

Coherent anti-Stokes Raman scattering (CARS) microscopy offers label-free chemical imaging capabilities, but its performance is constrained by small Raman scattering cross-section, strong non-resonant background (NRB), and limited…

We propose a Bayesian statistical model for analyzing coherent anti-Stokes Raman scattering (CARS) spectra. Our quantitative analysis includes statistical estimation of constituent line-shape parameters, underlying Raman signal,…

应用统计 · 统计学 2020-05-15 Teemu Härkönen , Lassi Roininen , Matthew T. Moores , Erik M. Vartiainen
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