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Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but…

计算机视觉与模式识别 · 计算机科学 2019-02-21 Aman Rana , Gregory Yauney , Alarice Lowe , Pratik Shah

Pathologists routinely use immunohistochemical (IHC)-stained tissue slides against MelanA in addition to hematoxylin and eosin (H&E)-stained slides to improve their accuracy in diagnosing melanomas. The use of diagnostic Deep Learning…

The fast development of self-supervised learning lowers the bar learning feature representation from massive unlabeled data and has triggered a series of research on change detection of remote sensing images. Challenges in adapting…

计算机视觉与模式识别 · 计算机科学 2022-12-07 Meiqi Hu , Chen Wu , Liangpei Zhang

We present SparseAttnNet, a new hierarchical attention-driven framework for efficient image classification that adaptively selects and processes only the most informative pixels from images. Traditional convolutional neural networks…

图像与视频处理 · 电气工程与系统科学 2025-05-13 Elad Yoshai , Dana Yagoda-Aharoni , Eden Dotan , Natan T. Shaked

Learning discriminative representations of unlabelled data is a challenging task. Contrastive self-supervised learning provides a framework to learn meaningful representations using learned notions of similarity measures from simple pretext…

计算机视觉与模式识别 · 计算机科学 2023-01-04 Nicklas Boserup , Raghavendra Selvan

Cell classification and counting in immunohistochemical cytoplasm staining images play a pivotal role in cancer diagnosis. Weakly supervised learning is a potential method to deal with labor-intensive labeling. However, the inconstant cell…

图像与视频处理 · 电气工程与系统科学 2022-03-01 Shichuan Zhang , Chenglu Zhu , Honglin Li , Jiatong Cai , Lin Yang

Large amounts of unlabelled data are commonplace for many applications in computational pathology, whereas labelled data is often expensive, both in time and cost, to acquire. We investigate the performance of unsupervised and supervised…

计算机视觉与模式识别 · 计算机科学 2019-07-27 Koen Dercksen , Wouter Bulten , Geert Litjens

In the present study, we propose a novel case-based similar image retrieval (SIR) method for hematoxylin and eosin (H&E)-stained histopathological images of malignant lymphoma. When a whole slide image (WSI) is used as an input query, it is…

Graph contrastive learning has been successfully applied in text classification due to its remarkable ability for self-supervised node representation learning. However, explicit graph augmentations may lead to a loss of semantics in the…

计算与语言 · 计算机科学 2024-11-28 Wei Ai , Jianbin Li , Ze Wang , Yingying Wei , Tao Meng , Yuntao Shou , Keqin Lib

Stain variations often decrease the generalization ability of deep learning based approaches in digital histopathology analysis. Two separate proposals, namely stain normalization (SN) and stain augmentation (SA), have been spotlighted to…

计算机视觉与模式识别 · 计算机科学 2023-03-03 Yiqing Shen , Yulin Luo , Dinggang Shen , Jing Ke

Multiplex imaging is revolutionizing pathology by enabling the simultaneous visualization of multiple biomarkers within tissue samples, providing molecular-level insights that traditional hematoxylin and eosin (H&E) staining cannot provide.…

图像与视频处理 · 电气工程与系统科学 2026-01-06 Hyun-Jic Oh , Junsik Kim , Zhiyi Shi , Yichen Wu , Yu-An Chen , Peter K Sorger , Hanspeter Pfister , Won-Ki Jeong

Medical imaging technologies are generating increasingly large amounts of high-quality, information-dense data. Despite the progress, practical use of advanced imaging technologies for research and diagnosis remains limited by cost and…

图像与视频处理 · 电气工程与系统科学 2023-07-24 Lucas Farndale , Robert Insall , Ke Yuan

Staining is essential in cell imaging and medical diagnostics but poses significant challenges, including high cost, time consumption, labor intensity, and irreversible tissue alterations. Recent advances in deep learning have enabled…

计算机视觉与模式识别 · 计算机科学 2025-04-15 Ziwang Xu , Lanqing Guo , Satoshi Tsutsui , Shuyan Zhang , Alex C. Kot , Bihan Wen

Prostate cancer (PCa) is graded by pathologists by examining the architectural pattern of cancerous epithelial tissue on hematoxylin and eosin (H&E) stained slides. Given the importance of gland morphology, automatically differentiating…

High-fidelity registration of histopathological whole slide images (WSIs), such as hematoxylin & eosin (H&E) and immunohistochemistry (IHC), is vital for integrated molecular analysis but challenging to evaluate without ground-truth (GT)…

计算机视觉与模式识别 · 计算机科学 2026-02-05 Shikha Dubey , Patricia Raciti , Kristopher Standish , Albert Juan Ramon , Erik Ames Burlingame

Accurate gland segmentation in histopathology images is essential for cancer diagnosis and prognosis. However, significant variability in Hematoxylin and Eosin (H&E) staining and tissue morphology, combined with limited annotated data,…

计算机视觉与模式识别 · 计算机科学 2025-08-05 Ha-Hieu Pham , Nguyen Lan Vi Vu , Thanh-Huy Nguyen , Ulas Bagci , Min Xu , Trung-Nghia Le , Huy-Hieu Pham

Most matting researches resort to advanced semantics to achieve high-quality alpha mattes, and direct low-level features combination is usually explored to complement alpha details. However, we argue that appearance-agnostic integration can…

计算机视觉与模式识别 · 计算机科学 2022-10-14 Yu Qiao , Yuhao Liu , Ziqi Wei , Yuxin Wang , Qiang Cai , Guofeng Zhang , Xin Yang

Scene Text Recognition (STR) is challenging in extracting effective character representations from visual data when text is unreadable. Permutation language modeling (PLM) is introduced to refine character predictions by jointly capturing…

计算机视觉与模式识别 · 计算机科学 2026-02-04 Honghui Chen , Yuhang Qiu , Jiabao Wang , Pingping Chen , Nam Ling

Histological examination is crucial for cancer diagnosis, including hematoxylin and eosin (H&E) staining for mapping morphology and immunohistochemistry (IHC) staining for revealing chemical information. Recently developed two-color…

The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2 (HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies and diagnostic decisions, guiding cancer treatment and investigation…