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Dynamic treatment regimes (DTRs) have received an increasing interest in recent years. DTRs are sequences of treatment decision rules tailored to patient-level information. The main goal of the DTR study is to identify an optimal DTR, a…

统计方法学 · 统计学 2024-04-09 Dan Liu , Wenqing He

A dynamic treatment regimen (DTR) is a set of decision rules to personalize treatments for an individual using their medical history. The Q-learning-based Q-shared algorithm has been used to develop DTRs that involve decision rules shared…

机器学习 · 统计学 2024-12-05 Palash Ghosh , Xinru Wang , Trikay Nalamada , Shruti Agarwal , Maria Jahja , Bibhas Chakraborty

This paper presents the first deep reinforcement learning (DRL) framework to estimate the optimal Dynamic Treatment Regimes from observational medical data. This framework is more flexible and adaptive for high dimensional action and state…

人工智能 · 计算机科学 2018-01-30 Ning Liu , Ying Liu , Brent Logan , Zhiyuan Xu , Jian Tang , Yanzhi Wang

The goal of precision medicine is to provide individualized treatment at each stage of chronic diseases, a concept formalized by Dynamic Treatment Regimes (DTR). These regimes adapt treatment strategies based on decision rules learned from…

统计方法学 · 统计学 2025-06-09 Sophia Yazzourh , Nicolas Savy , Philippe Saint-Pierre , Michael R. Kosorok

In this paper, we introduce Quantum-Train-Based Distributed Multi-Agent Reinforcement Learning (Dist-QTRL), a novel approach to addressing the scalability challenges of traditional Reinforcement Learning (RL) by integrating quantum…

量子物理 · 物理学 2024-12-13 Kuan-Cheng Chen , Samuel Yen-Chi Chen , Chen-Yu Liu , Kin K. Leung

Reinforcement learning (RL) has garnered increasing recognition for its potential to optimise dynamic treatment regimes (DTRs) in personalised medicine, particularly for drug dosage prescriptions and medication recommendations. However, a…

机器学习 · 计算机科学 2024-05-30 Zhiyao Luo , Mingcheng Zhu , Fenglin Liu , Jiali Li , Yangchen Pan , Jiandong Zhou , Tingting Zhu

Dynamic treatment regimes (DTRs) are personalized, adaptive strategies designed to guide the sequential allocation of treatments based on individual characteristics over time. Before each treatment assignment, covariate information is…

统计方法学 · 统计学 2025-07-24 Kai Chen , Yuqian Zhang

To mitigate the limitation that the classical reinforcement learning (RL) framework heavily relies on identical training and test environments, Distributionally Robust RL (DRRL) has been proposed to enhance performance across a range of…

机器学习 · 统计学 2024-09-24 Zhipeng Liang , Xiaoteng Ma , Jose Blanchet , Jiheng Zhang , Zhengyuan Zhou

Dynamic treatment regimes (DTRs) formalize medical decision-making as a sequence of rules for different stages, mapping patient-level information to recommended treatments. In practice, estimating an optimal DTR using observational data…

统计方法学 · 统计学 2024-12-11 Jian Sun , Bo Fu , Li Su

In the rapidly changing healthcare landscape, the implementation of offline reinforcement learning (RL) in dynamic treatment regimes (DTRs) presents a mix of unprecedented opportunities and challenges. This position paper offers a critical…

机器学习 · 计算机科学 2024-06-05 Zhiyao Luo , Yangchen Pan , Peter Watkinson , Tingting Zhu

Medical treatments often involve a sequence of decisions, each informed by previous outcomes. This process closely aligns with reinforcement learning (RL), a framework for optimizing sequential decisions to maximize cumulative rewards under…

机器学习 · 计算机科学 2024-10-15 Ali Shirali , Alexander Schubert , Ahmed Alaa

Background: Clinical diagnosis is typically reached by following a series of steps recommended by guidelines authored by colleges of experts. Accordingly, guidelines play a crucial role in rationalizing clinical decisions but suffer from…

机器学习 · 计算机科学 2024-04-10 Lillian Muyama , Antoine Neuraz , Adrien Coulet

The study of precision medicine involves dynamic treatment regimes (DTRs), which are sequences of treatment decision rules recommended by taking patient-level information as input. The primary goal of the DTR study is to identify an optimal…

统计方法学 · 统计学 2024-12-11 Dan Liu , Wenqing He

In this paper, a novel training paradigm inspired by quantum computation is proposed for deep reinforcement learning (DRL) with experience replay. In contrast to traditional experience replay mechanism in DRL, the proposed deep…

机器学习 · 计算机科学 2021-01-07 Qing Wei , Hailan Ma , Chunlin Chen , Daoyi Dong

A dynamic treatment regime effectively incorporates both accrued information and long-term effects of treatment from specially designed clinical trials. As these become more and more popular in conjunction with longitudinal data from…

统计方法学 · 统计学 2011-08-29 Rui Song , Weiwei Wang , Donglin Zeng , Michael R. Kosorok

This paper introduces the QDQN-DPER framework to enhance the efficiency of quantum reinforcement learning (QRL) in solving sequential decision tasks. The framework incorporates prioritized experience replay and asynchronous training into…

量子物理 · 物理学 2023-04-20 Samuel Yen-Chi Chen

Distributionally robust reinforcement learning (DRRL) focuses on designing policies that achieve good performance under model uncertainties. The goal is to maximize the worst-case long-term discounted reward, where the data for RL comes…

机器学习 · 计算机科学 2026-03-17 Saptarshi Mandal , Yashaswini Murthy , R. Srikant

Deep reinforcement learning has been recognized as an efficient technique to design optimal strategies for different complex systems without prior knowledge of the control landscape. To achieve a fast and precise control for quantum…

量子物理 · 物理学 2021-01-05 Hailan Ma , Daoyi Dong , Steven X. Ding , Chunlin Chen

Reinforcement learning (RL) is one of the most practical ways to learn from real-life use-cases. Motivated from the cognitive methods used by humans makes it a widely acceptable strategy in the field of artificial intelligence. Most of the…

人工智能 · 计算机科学 2026-04-14 Abhishek Sawaika , Samuel Yen-Chi Chen , Udaya Parampalli , Rajkumar Buyya

Dynamic treatment regimens (DTRs) aim at tailoring individualized sequential treatment rules that maximize cumulative beneficial outcomes by accommodating patients' heterogeneity in decision-making. For many chronic diseases including type…

统计方法学 · 统计学 2024-04-23 Mochuan Liu , Yuanjia Wang , Haoda Fu , Donglin Zeng
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