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AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in…

人工智能 · 计算机科学 2025-01-10 Haokun Liu , Yangqiaoyu Zhou , Mingxuan Li , Chenfei Yuan , Chenhao Tan

With the exponential increase in online scientific literature, identifying reliable domain-specific data has become increasingly important but also very challenging. Manual data collection and filtering for domain-specific scientific…

信息检索 · 计算机科学 2026-03-10 Nikita Gautam , Doina Caragea , Ignacio Ciampitti , Federico Gomez

Identifying drug-target interactions is essential for developing effective therapeutics. Binding affinity quantifies these interactions, and traditional approaches rely on computationally intensive 3D structural data. In contrast, language…

定量方法 · 定量生物学 2024-11-08 Radheesh Sharma Meda , Amir Barati Farimani

The recommendation of medication is a vital aspect of intelligent healthcare systems, as it involves prescribing the most suitable drugs based on a patient's specific health needs. Unfortunately, many sophisticated models currently in use…

信息检索 · 计算机科学 2025-01-28 Qidong Liu , Xian Wu , Xiangyu Zhao , Yuanshao Zhu , Zijian Zhang , Feng Tian , Yefeng Zheng

Tabular data synthesis is crucial in machine learning, yet existing general methods-primarily based on statistical or deep learning models-are highly data-dependent and often fall short in recommender systems. This limitation arises from…

信息检索 · 计算机科学 2025-02-12 Jingtong Gao , Zhaocheng Du , Xiaopeng Li , Yichao Wang , Xiangyang Li , Huifeng Guo , Ruiming Tang , Xiangyu Zhao

There is a growing trend of teaching large language models (LLMs) to solve mathematical problems through coding. Existing studies primarily focus on prompting powerful, closed-source models to generate seed training data followed by…

计算与语言 · 计算机科学 2024-08-29 Dian Yu , Baolin Peng , Ye Tian , Linfeng Song , Haitao Mi , Dong Yu

In Biomedical Natural Language Processing (BioNLP) tasks, such as Relation Extraction, Named Entity Recognition, and Text Classification, the scarcity of high-quality data remains a significant challenge. This limitation poisons large…

计算与语言 · 计算机科学 2025-04-01 Zhengyi Zhao , Shubo Zhang , Bin Liang , Binyang Li , Kam-Fai Wong

Scaling laws have allowed Pre-trained Language Models (PLMs) into the field of causal reasoning. Causal reasoning of PLM relies solely on text-based descriptions, in contrast to causal discovery which aims to determine the causal…

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

计算与语言 · 计算机科学 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Pretrained language models (PLMs) have motivated research on what kinds of knowledge these models learn. Fill-in-the-blanks problem (e.g., cloze tests) is a natural approach for gauging such knowledge. BioLAMA generates prompts for…

计算与语言 · 计算机科学 2023-01-26 Zonghai Yao , Yi Cao , Zhichao Yang , Hong Yu

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

计算与语言 · 计算机科学 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

The use of neural language models to model human behavior has met with mixed success. While some work has found that the surprisal estimates from these models can be used to predict a wide range of human neural and behavioral responses,…

计算与语言 · 计算机科学 2023-12-01 Aryaman Chobey , Oliver Smith , Anzi Wang , Grusha Prasad

Recent claims of strong performance by Large Language Models (LLMs) on causal discovery are undermined by a key flaw: many evaluations rely on benchmarks likely included in pretraining corpora. Thus, apparent success suggests that LLM-only…

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Large Language Models (LLMs) and causal learning each hold strong potential for clinical decision making (CDM). However, their synergy remains poorly understood, largely due to the lack of systematic benchmarks evaluating their integration…

机器学习 · 计算机科学 2025-11-14 Linna Wang , Zhixuan You , Qihui Zhang , Jiunan Wen , Ji Shi , Yimin Chen , Yusen Wang , Fanqi Ding , Ziliang Feng , Li Lu

With the advent of large language models (LLMs), managing scientific literature via LLMs has become a promising direction of research. However, existing approaches often overlook the rich structural and semantic relevance among scientific…

社会与信息网络 · 计算机科学 2025-12-19 Jiasheng Zhang , Jialin Chen , Ali Maatouk , Ngoc Bui , Qianqian Xie , Leandros Tassiulas , Jie Shao , Hua Xu , Rex Ying

With the proliferation of open-sourced Large Language Models (LLMs) and efficient finetuning techniques, we are on the cusp of the emergence of numerous domain-specific LLMs that have been finetuned for expertise across specialized fields…

计算与语言 · 计算机科学 2023-06-28 Teo Susnjak

We present BEEP (Biomedical Evidence-Enhanced Predictions), a novel approach for clinical outcome prediction that retrieves patient-specific medical literature and incorporates it into predictive models. Based on each individual patient's…

计算与语言 · 计算机科学 2022-11-17 Aakanksha Naik , Sravanthi Parasa , Sergey Feldman , Lucy Lu Wang , Tom Hope

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

计算与语言 · 计算机科学 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

The rapid advancement of large language models (LLMs) in biological-medical applications has highlighted a gap between their potential and the limited scale and often low quality of available open-source annotated textual datasets. In…

计算与语言 · 计算机科学 2025-12-19 Xunxin Cai , Chengrui Wang , Qingqing Long , Yuanchun Zhou , Meng Xiao
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