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Accurate reconstruction of neuronal morphology is essential for classifying cell types and understanding brain connectivity. Recent advances in imaging and reconstruction techniques have greatly expanded the scale and quality of neuronal…

神经元与认知 · 定量生物学 2025-08-05 Wu Chen , Mingwei Liao , Xueyan Jia , Xiaowei Chen , Chi Xiao , Qingming Luo , Hui Gong , Anan Li

Automated segmentation of anatomical sub-regions with high precision has become a necessity to enable the quantification and characterization of cells/ tissues in histology images. Currently, a machine learning model to analyze…

图像与视频处理 · 电气工程与系统科学 2023-06-05 Hosein Barzekar , Hai Ngu , Han Hui Lin , Mohsen Hejrati , Steven Ray Valdespino , Sarah Chu , Baris Bingol , Somaye Hashemifar , Soumitra Ghosh

Automatic segmentation of neuronal topology is critical for handling large scale neuroimaging data, as it can greatly accelerate neuron annotation and analysis. However, the intricate morphology of neuronal branches and the occlusions among…

图像与视频处理 · 电气工程与系统科学 2025-08-01 Huayu Fu , Jiamin Li , Haozhi Qu , Xiaolin Hu , Zengcai Guo

Reconstructing multiple molecularly defined neurons from individual brains and across multiple brain regions can reveal organizational principles of the nervous system. However, high resolution imaging of the whole brain is a technically…

计算机视觉与模式识别 · 计算机科学 2019-03-19 James Gornet , Kannan Umadevi Venkataraju , Arun Narasimhan , Nicholas Turner , Kisuk Lee , H. Sebastian Seung , Pavel Osten , Uygar Sümbül

Neuron segmentation is the cornerstone of reconstructing comprehensive neuronal connectomes, which is essential for deciphering the functional organization of the brain. The irregular morphology and densely intertwined structures of neurons…

计算机视觉与模式识别 · 计算机科学 2026-01-23 Liuyun Jiang , Yizhuo Lu , Yanchao Zhang , Jiazheng Liu , Hua Han

Semantic segmentation of neuronal structures in 3D high-resolution fluorescence microscopy imaging of the human brain cortex can take advantage of bidimensional CNNs, which yield good results in neuron localization but lead to inaccurate…

图像与视频处理 · 电气工程与系统科学 2020-09-03 Filippo Maria Castelli , Matteo Roffilli , Giacomo Mazzamuto , Irene Costantini , Ludovico Silvestri , Francesco Saverio Pavone

We explore encoding brain symmetry into a neural network for a brain tumor segmentation task. A healthy human brain is symmetric at a high level of abstraction, and the high-level asymmetric parts are more likely to be tumor regions. Paying…

计算机视觉与模式识别 · 计算机科学 2017-11-20 Hejia Zhang , Xia Zhu , Theodore L. Willke

Whole-brain neural connectivity data are now available from viral tracing experiments, which reveal the connections between a source injection site and elsewhere in the brain. These hold the promise of revealing spatial patterns of…

神经元与认知 · 定量生物学 2016-10-27 Kameron Decker Harris , Stefan Mihalas , Eric Shea-Brown

Neuroanatomical segmentation in magnetic resonance imaging (MRI) of the brain is a prerequisite for volume, thickness and shape measurements. This work introduces a new highly accurate and versatile method based on 3D convolutional neural…

定量方法 · 定量生物学 2019-02-07 Philip Novosad , Vladimir Fonov , D. Louis Collins

Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for…

图像与视频处理 · 电气工程与系统科学 2019-07-04 Pawel Mlynarski , Hervé Delingette , Hamza Alghamdi , Pierre-Yves Bondiau , Nicholas Ayache

Neural circuit reconstruction at single synapse resolution is increasingly recognized as crucially important to decipher the function of biological nervous systems. Volume electron microscopy in serial transmission or scanning mode has been…

计算机视觉与模式识别 · 计算机科学 2018-05-09 Larissa Heinrich , Jan Funke , Constantin Pape , Juan Nunez-Iglesias , Stephan Saalfeld

Automated sample preparation and electron microscopy enables acquisition of very large image data sets. These technical advances are of special importance to the field of neuroanatomy, as 3D reconstructions of neuronal processes at the nm…

The throughput of electron microscopes has increased significantly in recent years, enabling detailed analysis of cell morphology and ultrastructure. Analysis of neural circuits at single-synapse resolution remains the flagship target of…

计算机视觉与模式识别 · 计算机科学 2019-08-07 Constantin Pape , Alex Matskevych , Adrian Wolny , Julian Hennies , Giula Mizzon , Marion Louveaux , Jacob Musser , Alexis Maizel , Detlev Arendt , Anna Kreshuk

Recent developments within memory-augmented neural networks have solved sequential problems requiring long-term memory, which are intractable for traditional neural networks. However, current approaches still struggle to scale to large…

人工智能 · 计算机科学 2017-10-16 Jakob Merrild , Mikkel Angaju Rasmussen , Sebastian Risi

In comparative neuroanatomy, the characterization of brain cytoarchitecture is critical to a better understanding of brain structure and function, as it helps to distill information on the development, evolution, and distinctive features of…

图像与视频处理 · 电气工程与系统科学 2023-11-07 Valentina Vadori , Jean-Marie Graïc , Livio Finos , Livio Corain , Antonella Peruffo , Enrico Grisan

Accurate segmentation of blood vessels in brain magnetic resonance angiography (MRA) is essential for successful surgical procedures, such as aneurysm repair or bypass surgery. Currently, annotation is primarily performed through manual…

图像与视频处理 · 电气工程与系统科学 2025-09-09 Alexandra Bernadotte , Elfimov Nikita , Mikhail Shutov , Ivan Menshikov

A fundamental challenge in neuroscience is to decode mental states from brain activity. While functional magnetic resonance imaging (fMRI) offers a non-invasive approach to capture brain-wide neural dynamics with high spatial precision,…

图像与视频处理 · 电气工程与系统科学 2025-07-31 Yueh-Po Peng , Vincent K. M. Cheung , Li Su

Brain extraction (skull stripping) is a challenging problem in neuroimaging. It is due to the variability in conditions from data acquisition or abnormalities in images, making brain morphology and intensity characteristics changeable and…

计算机视觉与模式识别 · 计算机科学 2022-01-31 Duy H. M. Nguyen , Duy M. Nguyen , Mai T. N. Truong , Thu Nguyen , Khanh T. Tran , Nguyen A. Triet , Pham T. Bao , Binh T. Nguyen

Removing skull artifacts from functional magnetic images (fMRI) is a well understood and frequently encountered problem. Because the fMRI field has grown mostly due to human studies, many new tools were developed to handle human data.…

图像与视频处理 · 电气工程与系统科学 2019-12-09 Sidney Pontes-Filho , Annelene Gulden Dahl , Stefano Nichele , Gustavo Borges Moreno e Mello

Deep learning methods have surpassed the performance of traditional techniques on a wide range of problems in computer vision, but nearly all of this work has studied consumer photos, where precisely correct output is often not critical. It…

计算机视觉与模式识别 · 计算机科学 2018-07-24 Mingze Xu , Chenyou Fan , John D Paden , Geoffrey C Fox , David J Crandall