相关论文: On Pre-trained Language Models for Antibody

Designing protein mutants of both high stability and activity is a critical yet challenging task in protein engineering. Here, we introduce PRIME, a deep learning model, which can suggest protein mutants of improved stability and activity…

Supervised fine-tuning has become the predominant method for adapting large pretrained models to downstream tasks. However, recent studies have revealed that these models are vulnerable to backdoor attacks, where even a small number of…

Language model (LM) pre-training is useful in many language processing tasks. But can pre-trained LMs be further leveraged for more general machine learning problems? We propose an approach for using LMs to scaffold learning and…

Pathology text mining is a challenging task given the reporting variability and constant new findings in cancer sub-type definitions. However, successful text mining of a large pathology database can play a critical role to advance 'big…

Pre-trained language models have been shown to improve performance in many natural language tasks substantially. Although the early focus of such models was single language pre-training, recent advances have resulted in cross-lingual and…

Protein engineering is important for biomedical applications, but conventional approaches are often inefficient and resource-intensive. While deep learning (DL) models have shown promise, their training or implementation into protein…

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

The application of deep learning methods, particularly foundation models, in biological research has surged in recent years. These models can be text-based or trained on underlying biological data, especially omics data of various types.…

With the growing prominence of antibody-based therapeutics, antibody engineering has gained increasing attention as a critical area of research and development. Recent progress in transformer-based protein large language models (LLMs) has…

In recent years, protein-text models have gained significant attention for their potential in protein generation and understanding. Current approaches focus on integrating protein-related knowledge into large language models through…

Although pre-trained language models (PrLMs) have achieved significant success, recent studies demonstrate that PrLMs are vulnerable to adversarial attacks. By generating adversarial examples with slight perturbations on different levels…

Recent work using auxiliary prediction task classifiers to investigate the properties of LSTM representations has begun to shed light on why pretrained representations, like ELMo (Peters et al., 2018) and CoVe (McCann et al., 2017), are so…

The exploration of various vision-language tasks, such as visual captioning, visual question answering, and visual commonsense reasoning, is an important area in artificial intelligence and continuously attracts the research community's…

Pretrained language models (PLMs) display impressive performances and have captured the attention of the NLP community. Establishing best practices in pretraining has, therefore, become a major focus of NLP research, especially since…

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens. The effectiveness of antigen neutralisation and elimination hinges upon the strength, sensitivity, and specificity of the…

Pre-training language models (LMs) on large-scale unlabeled text data makes the model much easier to achieve exceptional downstream performance than their counterparts directly trained on the downstream tasks. In this work, we study what…

Pre-trained language models learn informative word representations on a large-scale text corpus through self-supervised learning, which has achieved promising performance in fields of natural language processing (NLP) after fine-tuning.…

Despite the widespread adoption, there is a lack of research into how various critical aspects of pretrained language models (PLMs) affect their performance in hate speech detection. Through five research questions, our findings and…

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…