中文
相关论文

相关论文: Ankh: Optimized Protein Language Model Unlocks Gen…

200 篇论文

Fine-tuning and inference with large Language Models (LM) are generally known to be expensive. Parameter-efficient fine-tuning over pretrained LMs reduces training memory by updating a small number of LM parameters but does not improve…

计算与语言 · 计算机科学 2024-06-05 Bowen Zhao , Hannaneh Hajishirzi , Qingqing Cao

Bengali is an underrepresented language in NLP research. However, it remains a challenge due to its unique linguistic structure and computational constraints. In this work, we systematically investigate the challenges that hinder Bengali…

计算与语言 · 计算机科学 2025-08-01 Shimanto Bhowmik , Tawsif Tashwar Dipto , Md Sazzad Islam , Sheryl Hsu , Tahsin Reasat

Automated Program Repair (APR) uses various tools and techniques to help developers achieve functional and error-free code faster. In recent years, Large Language Models (LLMs) have gained popularity as components in APR tool chains because…

软件工程 · 计算机科学 2025-07-29 Roman Macháček , Anastasiia Grishina , Max Hort , Leon Moonen

Protein language models (PLMs) encode rich biological information, yet their internal neuron representations are poorly understood. We introduce the first automated framework for labeling every neuron in a PLM with biologically grounded…

机器学习 · 计算机科学 2025-07-10 Arjun Banerjee , David Martinez , Camille Dang , Ethan Tam

Pretrained language models (PLMs) have produced substantial improvements in discourse-aware neural machine translation (NMT), for example, improved coherence in spoken language translation. However, the underlying reasons for their strong…

计算与语言 · 计算机科学 2023-06-01 Zhihong Huang , Longyue Wang , Siyou Liu , Derek F. Wong

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

机器学习 · 计算机科学 2023-01-04 Lirong Wu , Yufei Huang , Haitao Lin , Stan Z. Li

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

定量方法 · 定量生物学 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

In the evolutionary computing community, the remarkable language-handling capabilities and reasoning power of large language models (LLMs) have significantly enhanced the functionality of evolutionary algorithms (EAs), enabling them to…

神经与进化计算 · 计算机科学 2025-09-25 Jiao Liu , Zhu Sun , Shanshan Feng , Caishun Chen , Yew-Soon Ong

Large Audio-Language Models (LALMs) have demonstrated strong performance in audio understanding and generation. Yet, our extensive benchmarking reveals that their behavior is largely generic (e.g., summarizing spoken content) and fails to…

计算与语言 · 计算机科学 2026-01-08 Yuwen Wang , Xinyuan Qian , Tian-Hao Zhang , Jiaran Gao , Yuchen Pan , Xin Wang , Zhou Pan , Chen Wei , Yiming Wang

Evolutionary algorithms excel in solving complex optimization problems, especially those with multiple objectives. However, their stochastic nature can sometimes hinder rapid convergence to the global optima, particularly in scenarios…

神经与进化计算 · 计算机科学 2024-05-10 Zeyi Wang , Songbai Liu , Jianyong Chen , Kay Chen Tan

Vision-Language Models (VLMs) excel at many multimodal tasks, yet they frequently struggle with tasks requiring precise understanding and handling of fine-grained visual elements. This is mainly due to information loss during image encoding…

计算机视觉与模式识别 · 计算机科学 2025-10-03 Xuchen Li , Xuzhao Li , Jiahui Gao , Renjie Pi , Shiyu Hu , Wentao Zhang

Training large language models (LLMs) is often constrained by GPU memory limitations. To alleviate memory pressure, activation recomputation and data compression have been proposed as two major strategies. However, both approaches have…

机器学习 · 计算机科学 2025-08-11 Ping Chen , Zhuohong Deng , Ping Li , Shuibing He , Hongzi Zhu , Yi Zheng , Zhefeng Wang , Baoxing Huai , Minyi Guo

Current Large Language Models (LLMs) for understanding proteins primarily treats amino acid sequences as a text modality. Meanwhile, Protein Language Models (PLMs), such as ESM-2, have learned massive sequential evolutionary knowledge from…

机器学习 · 计算机科学 2024-12-17 Nuowei Liu , Changzhi Sun , Tao Ji , Junfeng Tian , Jianxin Tang , Yuanbin Wu , Man Lan

Machine learning and the use of neural networks has increased precipitously over the past few years primarily due to the ever-increasing accessibility to data and the growth of computation power. It has become increasingly easy to harness…

机器学习 · 计算机科学 2020-08-05 Aaron Hein , Casey Cole , Homayoun Valafar

Understanding the relationships between protein sequence, structure and function is a long-standing biological challenge with manifold implications from drug design to our understanding of evolution. Recently, protein language models have…

定量方法 · 定量生物学 2024-01-29 Dexiong Chen , Philip Hartout , Paolo Pellizzoni , Carlos Oliver , Karsten Borgwardt

The advancement of Large Language Models (LLMs) has significantly boosted performance in natural language processing (NLP) tasks. However, the deployment of high-performance LLMs incurs substantial costs, primarily due to the increased…

机器学习 · 计算机科学 2024-03-22 Saehan Jo , Immanuel Trummer

Large language models (LLMs) have demonstrated significant success in natural language processing (NLP) tasks and have shown promising results in other domains such as protein sequence generation. However, there remain salient differences…

生物大分子 · 定量生物学 2024-11-12 Aayush Shah , Shankar Jayaratnam

Large Language Models (LLMs) excel in handling general knowledge tasks, yet they struggle with user-specific personalization, such as understanding individual emotions, writing styles, and preferences. Personalized Large Language Models…

人工智能 · 计算机科学 2025-09-23 Jiahong Liu , Zexuan Qiu , Zhongyang Li , Quanyu Dai , Wenhao Yu , Jieming Zhu , Minda Hu , Menglin Yang , Tat-Seng Chua , Irwin King

Unlike the predictable scaling laws in natural language processing and computer vision, protein language models (PLMs) scale poorly: for many tasks, models within the same family plateau or even decrease in performance, with mid-sized…

机器学习 · 计算机科学 2026-03-10 Darius Catrina , Christian Bepler , Samuel Sledzieski , Rohit Singh

The remarkable performance of large language models (LLMs) in various language tasks has attracted considerable attention. However, the ever-increasing size of these models presents growing challenges for deployment and inference.…

计算与语言 · 计算机科学 2025-02-21 Jiayu Qin , Jianchao Tan , Kefeng Zhang , Xunliang Cai , Wei Wang