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X-ray phase-contrast imaging has experienced rapid development over the last few decades, and in this technology, the phase modulation strategy of phase-stepping is used most widely to measure the sample's phase signal. However, because of…

医学物理 · 物理学 2017-12-06 Faiz Wali , Shenghao Wang , Huajie Han , Kun Gao , Zhao Wu , Peiping Zhu , Yangchao Tiana

Phase contrast microscopy (PCM) has been widely used in biomedicine research, which allows users to observe objectives without staining or killing them. One important related research is to employ PCM to monitor live cells. How to segment…

计算机视觉与模式识别 · 计算机科学 2019-11-26 Lin Zhang

Since their discovery in 1896, x-rays have had a profound impact on science, medicine and technology. Here we show that the x-rays from a novel tabletop source of bright coherent synchrotron radiation can be applied to phase contrast…

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

X-ray fluorescence computed tomography based on sheet-beam can save a huge amount of time to obtain a whole set of projections using synchrotron. However, it is clearly unpractical for most biomedical research laboratories. In this paper,…

医学物理 · 物理学 2017-03-07 Shanghai Jiang , Peng He , Luzhen Deng , Mianyi Chen , Biao Wei

Imaging of microvasculature is primarily performed with X-ray contrast agents, owing to the wide availability of absorption-contrast laboratory source microCT compared to phase contrast capable devices. Standard commercial contrast agents…

组织与器官 · 定量生物学 2023-01-18 Willy Kuo , Ngoc An Le , Bernhard Spingler , Georg Schulz , Bert Müller , Vartan Kurtcuoglu

The visualization of pure phase objects by wavefront sensing has important applications ranging from surface profiling to biomedical microscopy, and generally requires bulky and complicated setups involving optical spatial filtering,…

光学 · 物理学 2023-08-29 Jianing Liu , Hao Wang , Yuyu Li , Lei Tian , Roberto Paiella

This study presents a comprehensive workflow for investigating particulate materials through combined 360{\deg} electron tomography (ET), nano-computed X-ray tomography (nanoCT), and micro-computed X-ray tomography (microCT), alongside a…

Recently, X-ray interferometers with more than one phase grating have been developed for differential phase contrast (DPC) imaging. In this study, a novel framework is developed to predict such interferometers' angular sensitivity responses…

仪器与探测器 · 物理学 2020-06-25 Jianwei Chen , Jiecheng Yang , Peiping Zhu , Ting Su , Huitao Zhang , Hairong Zheng , Dong Liang , Yongshuai Ge

The use of x-ray imaging in medicine and other research is well known. Generally, the image quality is proportional to the total flux, but high photon energy could severely damage the specimen, so how to decrease the radiation dose while…

医学物理 · 物理学 2017-09-05 Ai-Xin Zhang , Yu-Hang He , Ling-An Wu , Li-Ming Chen , Bing-Bing Wang

X-ray imaging is a prevalent technique for non-invasively visualizing the interior of the human body and opaque instruments. In most commercial x-ray modalities, an image is formed by measuring the x-rays that pass through the object of…

医学物理 · 物理学 2023-05-23 A. Ben Yehuda , O. Sefi , Y. Klein , R. H Shukrun , H. Schwartz , E. Cohen , S. Shwartz

A new approach for image reconstruction in THz computed tomography (THz-CT) is presented. Based on a geometrical optics model containing the THz signal amplitude and phase, a novel algorithm for extracting an average phase from the measured…

X-ray interferometry provides valuable information in terms of attenuation, small-angle scatter, and differential phase contrast. This multi-modal contrast can aid in many clinical applications, such as lung diseases and breast cancer.…

光学 · 物理学 2026-03-12 Murtuza S. Taqi , Joyoni Dey , Hunter C. Meyer

Ptychography provides highly efficient imaging in scanning transmission electron microscopy (STEM), but questions have remained over its applicability to strongly scattering samples such as those most commonly seen in materialsscience.…

应用物理 · 物理学 2022-09-07 C. Gao , C. Hofer , D. Jannis , A. Béché , J. Verbeeck , T. J. Pennycook

Investigating the structure of matter at the nanoscale non destructively is a key capability enabled by X-ray imaging. One of the most powerful nano-imaging methods is X-ray ptychography, a coherent diffraction imaging technique that has…

X-ray computed tomography is a powerful tool for volumetric imaging, but requires the collection of a large number of low-noise projection images, which is often too time consuming, limiting its applicability. In our previous work…

图像与视频处理 · 电气工程与系统科学 2025-05-02 Zhenduo Shang , Thomas Blumensath

Spectral CT has great potential for a variety of clinical applications due to the improved material discrimination with respect to conventional CT. Many clinical and preclinical spectral CT systems have two spectral channels for dual-energy…

医学物理 · 物理学 2020-10-17 Matthew Tivnan , Wenying Wang , J. Webster Stayman

Minibeam and microbeam radiation therapy promise improved treatment outcomes through reduced normal tissue toxicity at better tumor control rates. The lack of suitable compact radiation sources limits the clinical application of minibeams…