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The rapid adoption of transformer-based models in computational pathology has enabled prediction of molecular and clinical biomarkers from H&E whole-slide images, yet interpretability has not kept pace with model complexity. While…

Manual counting of mitotic tumor cells in tissue sections constitutes one of the strongest prognostic markers for breast cancer. This procedure, however, is time-consuming and error-prone. We developed a method to automatically detect…

Melanoma detection is vital for early diagnosis and effective treatment. While deep learning models on dermoscopic images have shown promise, they require specialized equipment, limiting their use in broader clinical settings. This study…

计算机视觉与模式识别 · 计算机科学 2026-05-20 Volodymyr Sydorskyi , Igor Krashenyi , Oleksii Yakubenko

Pathological diagnosis is the gold standard for cancer diagnosis, but it is labor-intensive, in which tasks such as cell detection, classification, and counting are particularly prominent. A common solution for automating these tasks is…

图像与视频处理 · 电气工程与系统科学 2021-10-27 Anyu Mao , Jialun Wu , Xinrui Bao , Zeyu Gao , Tieliang Gong , Chen Li

We present a nonparametric Bayesian method for disease subtype discovery in multi-dimensional cancer data. Our method can simultaneously analyse a wide range of data types, allowing for both agreement and disagreement between their…

基因组学 · 定量生物学 2013-04-16 Richard S. Savage , Zoubin Ghahramani , Jim E. Griffin , Paul Kirk , David L. Wild

Anomaly detection is important in many real-life applications. Recently, self-supervised learning has greatly helped deep anomaly detection by recognizing several geometric transformations. However these methods lack finer features, usually…

计算机视觉与模式识别 · 计算机科学 2022-12-12 Loic Jezequel , Ngoc-Son Vu , Jean Beaudet , Aymeric Histace

The cells and their spatial patterns in the tumor microenvironment (TME) play a key role in tumor evolution, and yet the latter remains an understudied topic in computational pathology. This study, to the best of our knowledge, is among the…

定量方法 · 定量生物学 2021-09-21 Pingjun Chen , Muhammad Aminu , Siba El Hussein , Joseph D. Khoury , Jia Wu

Automated mitotic detection in time-lapse phasecontrast microscopy provides us much information for cell behavior analysis, and thus several mitosis detection methods have been proposed. However, these methods still have two problems; 1)…

机器学习 · 计算机科学 2020-06-02 Kazuya Nishimura , Ryoma Bise

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

图像与视频处理 · 电气工程与系统科学 2023-03-21 Yinsheng He , Xingyu Li

Breast cancer is one of the leading causes of mortality in women. Early detection and treatment are imperative for improving survival rates, which have steadily increased in recent years as a result of more sophisticated…

计算机视觉与模式识别 · 计算机科学 2018-02-27 Sulaiman Vesal , Nishant Ravikumar , AmirAbbas Davari , Stephan Ellmann , Andreas Maier

Machine learning models for medical image analysis often suffer from poor performance on important subsets of a population that are not identified during training or testing. For example, overall performance of a cancer detection model may…

机器学习 · 计算机科学 2019-11-18 Luke Oakden-Rayner , Jared Dunnmon , Gustavo Carneiro , Christopher Ré

Canine mammary carcinoma (CMC) has been used as a model to investigate the pathogenesis of human breast cancer and the same grading scheme is commonly used to assess tumor malignancy in both. One key component of this grading scheme is the…

计算机视觉与模式识别 · 计算机科学 2020-11-30 Marc Aubreville , Christof A. Bertram , Taryn A. Donovan , Christian Marzahl , Andreas Maier , Robert Klopfleisch

One issue with computer based histopathology image analysis is that the size of the raw image is usually very large. Taking the raw image as input to the deep learning model would be computationally expensive while resizing the raw image to…

计算机视觉与模式识别 · 计算机科学 2019-03-01 Bolei Xu , Jingxin Liu , Xianxu Hou , Bozhi Liu , Jon Garibaldi , Ian O. Ellis , Andy Green , Linlin Shen , Guoping Qiu

Breast cancer screening, primarily conducted through mammography, is often supplemented with ultrasound for women with dense breast tissue. However, existing deep learning models analyze each modality independently, missing opportunities to…

图像与视频处理 · 电气工程与系统科学 2023-11-16 Yiqiu Shen , Jungkyu Park , Frank Yeung , Eliana Goldberg , Laura Heacock , Farah Shamout , Krzysztof J. Geras

With the development of medical imaging technology, medical images have become an important basis for doctors to diagnose patients. The brain structure in the collected data is complicated, thence, doctors are required to spend plentiful…

图像与视频处理 · 电气工程与系统科学 2020-07-10 Nan Wang , Chengwei Chen , Yuan Xie , Lizhuang Ma

Anomaly detection in medical imaging plays a crucial role in identifying pathological regions across various imaging modalities, such as brain MRI, liver CT, and carotid ultrasound (US). However, training fully supervised segmentation…

图像与视频处理 · 电气工程与系统科学 2025-07-29 Yuan Bi , Lucie Huang , Ricarda Clarenbach , Reza Ghotbi , Angelos Karlas , Nassir Navab , Zhongliang Jiang

Ovarian cancer remains a challenging malignancy to diagnose and manage, with prognosis heavily dependent on the stage at detection. Accurate grading and staging, primarily based on histopathological examination of biopsy tissue samples, are…

医学物理 · 物理学 2025-05-16 Ashmit K Mishra , Mousa Alrubayan , Prabhakar Pradhan

The detection of weak, spatially distributed anomalies in volumetric medical imaging remains challenging due to the difficulty of integrating subtle signals across non-adjacent regions. This study presents a controlled comparison of sixteen…

计算机视觉与模式识别 · 计算机科学 2025-12-12 Lynn Kandakji , William Woof , Nikolas Pontikos

The automatic analysis of subtle changes between longitudinal MR images is an important task as it is still a challenging issue in scope of the breast medical image processing. In this paper we propose an effective automatic change…

图像与视频处理 · 电气工程与系统科学 2021-10-22 Narges Norouzi , Reza Azmi , Nooshin Noshiri , Robab Anbiaee

Artificial intelligence may assist healthcare systems in meeting increasing demand for pathology services while maintaining diagnostic quality and reducing turnaround time and costs. We aimed to investigate the performance of an…

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