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The cells and their spatial patterns in the tumor microenvironment (TME) play a key role in tumor evolution, and yet the latter remains an understudied topic in computational pathology. This study, to the best of our knowledge, is among the…

定量方法 · 定量生物学 2021-09-21 Pingjun Chen , Muhammad Aminu , Siba El Hussein , Joseph D. Khoury , Jia Wu

The heterogeneity of breast cancer presents considerable challenges for its early detection, prognosis, and treatment selection. Convolutional neural networks often neglect the spatial relationships within histopathological images, which…

计算机视觉与模式识别 · 计算机科学 2023-07-18 Akhila Krishna K , Ravi Kant Gupta , Nikhil Cherian Kurian , Pranav Jeevan , Amit Sethi

Cancer diagnosis, prognosis, and therapy response predictions from tissue specimens highly depend on the phenotype and topological distribution of constituting histological entities. Thus, adequate tissue representations for encoding…

The recent surge in performance for image analysis of digitised pathology slides can largely be attributed to the advances in deep learning. Deep models can be used to initially localise various structures in the tissue and hence facilitate…

图像与视频处理 · 电气工程与系统科学 2022-11-15 Simon Graham , Quoc Dang Vu , Mostafa Jahanifar , Shan E Ahmed Raza , Fayyaz Minhas , David Snead , Nasir Rajpoot

The structural and spatial arrangements of cells within tissues represent their functional states, making graph-based learning highly suitable for histopathology image analysis. Existing methods often rely on fixed graphs with predefined…

图像与视频处理 · 电气工程与系统科学 2025-10-16 Sudipta Paul , Amanda W. Lund , George Jour , Iman Osman , Bülent Yener

Pathologists routinely alternate between different magnifications when examining Whole-Slide Images, allowing them to evaluate both broad tissue morphology and intricate cellular details to form comprehensive diagnoses. However, existing…

Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric…

计算机视觉与模式识别 · 计算机科学 2023-10-06 Amruta Parulekar , Utkarsh Kanwat , Ravi Kant Gupta , Medha Chippa , Thomas Jacob , Tripti Bameta , Swapnil Rane , Amit Sethi

Different convolutional neural network (CNN) models have been tested for their application in histological image analyses. However, these models are prone to overfitting due to their large parameter capacity, requiring more data or valuable…

Spatial arrangement of cells of various types, such as tumor infiltrating lymphocytes and the advancing edge of a tumor, are important features for detecting and characterizing cancers. However, convolutional neural networks (CNNs) do not…

图像与视频处理 · 电气工程与系统科学 2019-08-15 Shrey Gadiya , Deepak Anand , Amit Sethi

Graph neural networks (GNNs) have achieved superior performance on node classification tasks in the last few years. Commonly, this is framed in a transductive semi-supervised learning setup wherein the entire graph, including the target…

机器学习 · 计算机科学 2021-10-11 Artun Bayer , Arindam Chowdhury , Santiago Segarra

Based on a large dataset containing thousands of real-world networks ranging from genetic, protein interaction, and metabolic networks to brain, language, ecology, and social networks we search for defining structural measures of the…

机器学习 · 计算机科学 2021-06-22 Máté Józsa , Alpár S. Lázár , Zsolt I. Lázár

Learning anatomical segmentation from heterogeneous labels in multi-center datasets is a common situation encountered in clinical scenarios, where certain anatomical structures are only annotated in images coming from particular medical…

图像与视频处理 · 电气工程与系统科学 2023-09-06 Nicolás Gaggion , Maria Vakalopoulou , Diego H. Milone , Enzo Ferrante

In radiologists' routine work, one major task is to read a medical image, e.g., a CT scan, find significant lesions, and describe them in the radiology report. In this paper, we study the lesion description or annotation problem. Given a…

计算机视觉与模式识别 · 计算机科学 2019-04-30 Ke Yan , Yifan Peng , Veit Sandfort , Mohammadhadi Bagheri , Zhiyong Lu , Ronald M. Summers

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

图像与视频处理 · 电气工程与系统科学 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

Automated classification of clinical transcriptions into medical specialties is essential for routing, coding, and clinical decision support, yet prior work on the widely used MTSamples benchmark suffers from severe data leakage caused by…

人工智能 · 计算机科学 2026-03-25 Pronob Kumar Barman , Pronoy Kumar Barman

In this study, a novel method of data augmentation has been presented for the segmentation of placental histological images when the labeled data are scarce. This method generates new realizations of the placenta intervillous morphology…

图像与视频处理 · 电气工程与系统科学 2022-10-10 Arash Rabbani , Masoud Babaei , Masoumeh Gharib

Many state-of-the art visualization techniques must be tailored to the specific type of dataset, its modality (CT, MRI, etc.), the recorded object or anatomical region (head, spine, abdomen, etc.) and other parameters related to the data…

图形学 · 计算机科学 2009-06-15 Dženan Zukić , Christof Rezk-Salama , Andreas Kolb

Survival prediction is a complex ordinal regression task that aims to predict the survival coefficient ranking among a cohort of patients, typically achieved by analyzing patients' whole slide images. Existing deep learning approaches…

计算机视觉与模式识别 · 计算机科学 2024-05-01 Minghao Han , Xukun Zhang , Dingkang Yang , Tao Liu , Haopeng Kuang , Jinghui Feng , Lihua Zhang

Graph Neural Networks (GNNs) have recently been found to excel in histopathology. However, an important histopathological task, where GNNs have not been extensively explored, is the classification of glomeruli health as an important…

Studying the cellular architecture of the human cerebral cortex is critical for understanding brain organization and function. It requires investigating complex texture patterns in histological images, yet automatic methods that scale…