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To identify the estimand in missing data problems and observational studies, it is common to base the statistical estimation on the "missing at random" and "no unmeasured confounder" assumptions. However, these assumptions are unverifiable…

统计方法学 · 统计学 2018-10-09 Qingyuan Zhao , Dylan S. Small , Bhaswar B. Bhattacharya

We provide an approach to exploratory data analysis in matched observational studies with a single intervention and multiple endpoints. In such settings, the researcher would like to explore evidence for actual treatment effects among these…

统计方法学 · 统计学 2025-12-10 Mengqi Lin , Colin Fogarty

Matching is one of the most widely used study designs for adjusting for measured confounders in observational studies. However, unmeasured confounding may exist and cannot be removed by matching. Therefore, a sensitivity analysis is…

统计方法学 · 统计学 2024-01-17 Jeffrey Zhang , Dylan Small , Siyu Heng

Inverse propensity weighting (IPW) is a popular method for estimating treatment effects from observational data. However, its correctness relies on the untestable (and frequently implausible) assumption that all confounders have been…

统计理论 · 数学 2023-08-04 Jacob Dorn , Kevin Guo

Unmeasured confounding, selection bias, and measurement error are well-known sources of bias in epidemiologic research. Methods for assessing these biases have their own limitations. Many quantitative sensitivity analysis approaches…

统计方法学 · 统计学 2021-08-11 Louisa H. Smith , Maya B. Mathur , Tyler J. VanderWeele

In this paper, we propose a robust method to estimate the average treatment effects in observational studies when the number of potential confounders is possibly much greater than the sample size. We first use a class of penalized…

统计方法学 · 统计学 2018-12-21 Yang Ning , Sida Peng , Kosuke Imai

A key objective of decomposition analysis is to identify a factor (the 'mediator') contributing to disparities in an outcome between social groups. In decomposition analysis, a scholarly interest often centers on estimating how much the…

统计方法学 · 统计学 2022-05-27 Soojin Park , Suyeon Kang , Chioun Lee , Shujie Ma

Propensity score matching is a common tool for adjusting for observed confounding in observational studies, but is known to have limitations in the presence of unmeasured confounding. In many settings, researchers are confronted with…

统计方法学 · 统计学 2017-12-08 Georgia Papadogeorgou , Christine Choirat , Corwin Zigler

This paper clarifies a fundamental difference between causal inference and traditional statistical inference by formalizing a mathematical distinction between their respective parameters. We connect two major approaches to causal inference,…

统计方法学 · 统计学 2025-08-29 Muye Liu , Jun Xie

We propose a novel method for sensitivity analysis to unobserved confounding in causal inference. The method builds on a copula-based causal graphical normalizing flow that we term $\rho$-GNF, where $\rho \in [-1,+1]$ is the sensitivity…

统计方法学 · 统计学 2025-08-13 Sourabh Balgi , Marc Braun , Jose M. Peña , Adel Daoud

The association between a continuous and an ordinal variable is commonly modeled through the polyserial correlation model. However, this model, which is based on a partially-latent normality assumption, may be misspecified in practice, due…

统计方法学 · 统计学 2026-02-11 Max Welz

Multivariate meta-analysis of test accuracy studies when tests are evaluated in terms of sensitivity and specificity at more than one threshold represents an effective way to synthesize results by fully exploiting the data, if compared to…

统计方法学 · 统计学 2019-01-29 Annamaria Guolo , Duc Khanh To

Unmeasured confounding and selection bias are often of concern in observational studies and may invalidate a causal analysis if not appropriately accounted for. Under outcome-dependent sampling, a latent factor that has causal effects on…

统计方法学 · 统计学 2022-08-03 Kendrick Qijun Li , Xu Shi , Wang Miao , Eric Tchetgen Tchetgen

Various methods have recently been proposed to estimate causal effects with confidence intervals that are uniformly valid over a set of data generating processes when high-dimensional nuisance models are estimated by post-model-selection or…

统计方法学 · 统计学 2025-10-07 Niloofar Moosavi , Tetiana Gorbach , Xavier de Luna

Spurious association arises from covariance between propensity for the treatment and individual risk for the outcome. For sensitivity analysis with stochastic counterfactuals we introduce a methodology to characterize uncertainty in causal…

统计方法学 · 统计学 2021-03-11 Brian Knaeble , Braxton Osting , Placede Tshiaba

The propensity score (PS) is often used to control for large numbers of covariates in high-dimensional healthcare database studies. The least absolute shrinkage and selection operator (LASSO) has become the most widely used tool for fitting…

统计方法学 · 统计学 2025-12-17 Richard Wyss , Ben B. Hansen , Georg Hahn , Lars van der Laan , Kueiyu Joshua Lin

We extend our previous work on sensitivity analysis for the risk ratio and difference contrasts under unmeasured confounding to any contrast. We prove that the bounds produced are still arbitrarily sharp, i.e. practically attainable. We…

统计方法学 · 统计学 2024-06-13 Jose M. Peña

The lack of non-parametric statistical tests for confounding bias significantly hampers the development of robust, valid and generalizable predictive models in many fields of research. Here I propose the partial and full confounder tests,…

机器学习 · 计算机科学 2025-05-30 Tamas Spisak

Contrasting marginal counterfactual survival curves across treatment arms is an effective and popular approach for inferring the causal effect of an intervention on a right-censored time-to-event outcome. A key challenge to drawing such…

统计方法学 · 统计学 2022-04-29 Andrew Ying , Yifan Cui , Eric J. Tchetgen Tchetgen

Large language models (LLMs) have demonstrated impressive capabilities across various tasks, but their performance is highly sensitive to the prompts utilized. This variability poses challenges for accurate assessment and user satisfaction.…

计算与语言 · 计算机科学 2024-10-17 Jingming Zhuo , Songyang Zhang , Xinyu Fang , Haodong Duan , Dahua Lin , Kai Chen