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Probabilistic Boolean Networks (PBNs) were introduced as a computational model for the study of complex dynamical systems, such as Gene Regulatory Networks (GRNs). Controllability in this context is the process of making strategic…

机器学习 · 计算机科学 2020-09-08 Georgios Papagiannis , Sotiris Moschoyiannis

In this paper, a deep reinforcement learning based method is proposed to obtain optimal policies for optimal infinite-horizon control of probabilistic Boolean control networks (PBCNs). Compared with the existing literatures, the proposed…

系统与控制 · 电气工程与系统科学 2023-04-10 Jingjie Ni , Fangfei Li , Zheng-Guang Wu

The area of Smart Power Grids needs to constantly improve its efficiency and resilience, to pro-vide high quality electrical power, in a resistant grid, managing faults and avoiding failures. Achieving this requires high component…

机器学习 · 计算机科学 2021-02-03 Pedro J. Rivera Torres , Carlos Gershenson García , Samir Kanaan Izquierdo

This paper investigates the stabilization of probabilistic Boolean networks (PBNs) via a novel pinning control strategy based on network structure. In a PBN, the evolution equation of each gene switches among a collection of candidate…

系统与控制 · 电气工程与系统科学 2020-10-26 Lin Lin , Jinde Cao , Jianquan Lu , Jie Zhong

Many organisms and cell types, from bacteria to cancer cells, exhibit a remarkable ability to adapt to fluctuating environments. Additionally, cells can leverage a memory of past environments to better survive previously-encountered…

机器学习 · 计算机科学 2025-01-29 Josiah C. Kratz , Jacob Adamczyk

Practitioners often rely on compute-intensive domain randomization to ensure reinforcement learning policies trained in simulation can robustly transfer to the real world. Due to unmodeled nonlinearities in the real system, however, even…

机器学习 · 计算机科学 2020-02-27 Gabriel I. Fernandez , Colin Togashi , Dennis W. Hong , Lin F. Yang

This paper proposes a lexicographic Deep Reinforcement Learning (DeepRL)-based approach to chance-constrained Markov Decision Processes, in which the controller seeks to ensure that the probability of satisfying the constraint is above a…

机器学习 · 计算机科学 2020-10-20 Alessandro Giuseppi , Antonio Pietrabissa

In this paper, we present a reinforcement learning (RL) method for solving optimal false data injection attack problems in probabilistic Boolean control networks (PBCNs) where the attacker lacks knowledge of the system model. Specifically,…

系统与控制 · 电气工程与系统科学 2023-11-30 Xianlun Peng , Yang Tang , Fangfei Li , Yang Liu

Training a deep neural network to maximize a target objective has become the standard recipe for successful machine learning over the last decade. These networks can be optimized with supervised learning, if the target objective is…

机器学习 · 计算机科学 2025-05-12 Bernhard Jaeger , Andreas Geiger

In distributed optimization, the practical problem-solving performance is essentially sensitive to algorithm selection, parameter setting, problem type and data pattern. Thus, it is often laborious to acquire a highly efficient method for a…

最优化与控制 · 数学 2024-01-04 Daokuan Zhu , Tianqi Xu , Jie Lu

Cellular reprogramming can be used for both the prevention and cure of different diseases. However, the efficiency of discovering reprogramming strategies with classical wet-lab experiments is hindered by lengthy time commitments and high…

机器学习 · 计算机科学 2025-03-04 Andrzej Mizera , Jakub Zarzycki

In this paper, we investigate the problem of controlling probabilistic Boolean control networks (PBCNs) to achieve reachability with maximum probability in the finite time horizon. We address three questions: 1) finding control policies…

系统与控制 · 电气工程与系统科学 2023-12-13 Hongyue Fan , Jingjie Ni , Fangfei Li

Reinforcement Learning (RL) has emerged as an efficient method of choice for solving complex sequential decision making problems in automatic control, computer science, economics, and biology. In this paper we present a model-free RL…

计算机科学中的逻辑 · 计算机科学 2019-09-13 Mohammadhosein Hasanbeig , Yiannis Kantaros , Alessandro Abate , Daniel Kroening , George J. Pappas , Insup Lee

Reinforcement learning (RL) involves sequential decision making in uncertain environments. The aim of the decision-making agent is to maximize the benefit of acting in its environment over an extended period of time. Finding an optimal…

人工智能 · 计算机科学 2007-05-23 Istvan Szita , Balint Takacs , Andras Lorincz

Bayesian reinforcement learning (BRL) is a method that merges principles from Bayesian statistics and reinforcement learning to make optimal decisions in uncertain environments. As a model-based RL method, it has two key components: (1)…

机器学习 · 统计学 2025-06-03 Shreya Sinha Roy , Richard G. Everitt , Christian P. Robert , Ritabrata Dutta

Proton pencil beam scanning (PBS) treatment planning for head and neck (H&N) cancers is a time-consuming and experience-demanding task where a large number of planning objectives are involved. Deep reinforcement learning (DRL) has recently…

定量方法 · 定量生物学 2024-09-19 Qingqing Wang , Chang Chang

Reinforcement Learning (RL) techniques have been increasingly applied in optimizing control systems. However, their application in quantum systems is hampered by the challenge of performing closed-loop control due to the difficulty in…

量子物理 · 物理学 2024-02-08 Tanmay Neema , Susmit Jha , Tuhin Sahai

This paper presents a deep reinforcement learning (DRL) framework for dynamic portfolio optimization under market uncertainty and risk. The proposed model integrates a Sharpe ratio-based reward function with direct risk control mechanisms,…

投资组合管理 · 定量金融 2025-11-17 Emmanuel Lwele , Sabuni Emmanuel , Sitali Gabriel Sitali

We develop a portfolio allocation framework that leverages deep learning techniques to address challenges arising from high-dimensional, non-stationary, and low-signal-to-noise market information. Our approach includes a dynamic embedding…

投资组合管理 · 定量金融 2025-01-31 Jinghai He , Cheng Hua , Chunyang Zhou , Zeyu Zheng

Deep Reinforcement Learning has enabled the learning of policies for complex tasks in partially observable environments, without explicitly learning the underlying model of the tasks. While such model-free methods achieve considerable…

机器学习 · 计算机科学 2017-01-11 Tanmay Shankar , Santosha K. Dwivedy , Prithwijit Guha
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