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One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the development of high-sensitivity tests and diagnostic kits is…

光学 · 物理学 2022-12-13 Junfei Wang , Zhenyu Xu , Domna G. Kotsifaki

Despite being extremely old concepts, plasmonics and surface plasmon resonance-based biosensors have been increasingly popular in the recent two decades due to the growing interest in nanooptics and are now of relevant significance in…

光学 · 物理学 2023-04-19 Giuseppina Simone

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Rapid progress in plasmonics biosensors and immunosensors brings many methodologies to employ resonant subwavelength structures associated with the physics of multipoles, Fano resonances, and analogous moments. Here, we review a broad range…

应用物理 · 物理学 2018-09-18 Arash Ahmadivand , Burak Gerislioglu

Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the…

应用物理 · 物理学 2017-08-02 Ozlem Yavas , Mikael Svedendahl , Paulina Dobosz , Vanesa Sanz , Romain Quidant

Three-dimensional (3D) imaging of the subcellular organisation and morphology of cells and tissues is essential for understanding biological function. Although staining is the most widely used approach for visualising biological samples…

Our atmosphere is constantly changing and new pathogens are erupting now and then and the existing pathogens are mutating continuously. Some of these pathogens, such as SARS-CoV-2, become so deadly that they put the whole technological…

定量方法 · 定量生物学 2021-05-26 Mohammad Muntasir Hassan , Farhan Sadik Sium , Fariba Islam , Sajid Muhaimin Choudhury

Low-profile patterned plasmonic surfaces are synergized with a broad class of silicon microstructures to greatly enhance near-field nanoscale imaging, sensing, and energy harvesting coupled with far-field free-space detection. This concept…

光学 · 物理学 2017-05-02 Hamid T. Chorsi , Ying Zhu , John X. J. Zhang

Fluorescence imaging and spectroscopy remain the most powerful tools for visualization with chemical and immunological specificity of labeled biomolecules, viruses, cellular organelles, and living cells in complex biological backgrounds.…

Biosensors are an essential tool for medical diagnostics, environmental monitoring and food safety. Typically, biosensors are designed to detect specific analytes through functionalization with the appropriate capture agents. However, the…

医学物理 · 物理学 2023-09-26 Simon J. Ward , Tengfei Cao , Xiang Zhou , Catie Chang , Sharon M. Weiss

Biomarker detection is the key to identifying health risks. However, designing sensitive biosensors in a single-use mode for disease diagnosis remains a major challenge. Here, we report sub-monolayer biolasers with remarkable repeatability…

Droplet microfluidics offers a versatile platform for analyzing liquid samples. Despite its potential, there is a lack of techniques that allow to reliably probe individual circulating droplets. The prospect of combining droplet…

定量方法 · 定量生物学 2024-03-08 Marc Sulliger , Jaime Ortega Arroyo , Romain Quidant

Luminescence imaging is invaluable for studying biological and material systems, particularly when advanced protocols that exploit temporal dynamics are employed. However, implementing such protocols often requires custom instrumentation,…

Two-dimensional materials and their van der Waals heterostructures enable a large range of applications, including label-free biosensing. Lattice mismatch and work function difference in the heterostructure material result in strain and…

介观与纳米尺度物理 · 物理学 2021-11-19 Tetyana Ignatova , Sajedeh Pourianejad , Xinyi Li , Kirby Schmidt , Frederick Aryeetey , Shyam Aravamudhan , Slava V. Rotkin

Biomedical and environmental testing currently require access to highly specialized facilities or extensive training. Current biochemical tests require complex reagents to achieve a simple human readable result such as a color change. This…

Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

Conventional histopathology has long been essential for disease diagnosis, relying on visual inspection of tissue sections. Immunohistochemistry aids in detecting specific biomarkers but is limited by its single-marker approach, restricting…

Optical detection of individual nanometer-sized analytes, virus particles, and protein molecules holds great promise for understanding and control of biological samples and healthcare applications. As fluorescent labels impose restrictions…

光学 · 物理学 2020-10-19 Martin Dieter Baaske , Peter Sebastian Neu , Michel Orrit

In recent years significant efforts have been made to design and fabricate functional nanomaterials for biomedical applications based on the control of light matter interaction at the nanometer scale. Among many other artificial materials,…

Dynamic speckle imaging, typically used in laser-illuminated surface diagnostics, has proven valuable for assessing biological activity. In this work, we demonstrate its feasibility in an endoscopic context using a disposable bronchoscope.…

仪器与探测器 · 物理学 2025-05-01 Aurélien plyer , Elise Colin , Enrique Garcia-Caurel
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