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Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-liquid and glass-liquid transitions. These transitions are biologically relevant to our understanding of embryonic development, wound healing, and…

软凝聚态物质 · 物理学 2020-07-22 Benjamin Loewe , Michael Chiang , Davide Marenduzzo , M. Cristina Marchetti

Tuning cell rearrangements is essential in collective cell movement that underlies cancer progression, wound repair, and embryonic development. A key question is how tissue material properties and morphology emerge from cellular factors…

生物物理 · 物理学 2025-07-15 Soumyadipta Ray , Santidan Biswas , Dipjyoti Das

Cell migration is important in many biological processes, including embryonic development, cancer metastasis, and wound healing. In these tissues, a cell's motion is often strongly constrained by its neighbors, leading to glassy dynamics.…

生物物理 · 物理学 2016-01-20 Dapeng Bi , J. H. Lopez , J. M. Schwarz , M. Lisa Manning

We use event driven simulations to analyze glassy dynamics as a function of density and energy dissipation in a two-dimensional bidisperse granular fluid under stationary conditions. Clear signatures of a glass transition are identified,…

统计力学 · 物理学 2011-10-05 Iraj Gholami , Andrea Fiege , Annette Zippelius

We study the solid-to-liquid transition in a two-dimensional fully periodic soft-glassy model with an imposed spatially heterogeneous stress. The model we consider consists of droplets of a dispersed phase jammed together in a continuous…

软凝聚态物质 · 物理学 2018-06-06 Matteo Lulli , Roberto Benzi , Mauro Sbragaglia

Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

组织与器官 · 定量生物学 2023-03-08 Nen Saito , Shuji Ishihara

Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy…

软凝聚态物质 · 物理学 2019-05-07 Michael Czajkowski , Daniel M. Sussman , M. Cristina Marchetti , M. Lisa Manning

Much attention has been devoted to water's metastable phase behavior, including polyamorphism (multiple amorphous solid phases), and the hypothesized liquid-liquid transition and associated critical point. However, the possible relationship…

软凝聚态物质 · 物理学 2021-06-09 Thomas E. Gartner , Salvatore Torquato , Roberto Car , Pablo G. Debenedetti

We consider the stationary state of a fluid comprised of inelastic hard spheres or disks under the influence of a random, momentum-conserving external force. Starting from the microscopic description of the dynamics, we derive a nonlinear…

统计力学 · 物理学 2013-02-25 W. T. Kranz , M. Sperl , A. Zippelius

We study the interplay between the fluid-crystal transition and the glass transition of elastic sphere system with polydispersity using nonequilibrium molecular dynamics simulations. It is found that the end point of the crystal-fluid…

统计力学 · 物理学 2010-09-29 Tomoaki Nogawa , Nobuyasu Ito , Hiroshi Watanabe

Cell monolayers and epithelial tissues display slow dynamics during the liquid-glass transitions, a phenomenon with direct relevance to embryogenesis, tumor metastases, and wound healing. In active cells, persistent motion and cell…

软凝聚态物质 · 物理学 2024-01-25 Meng-Yuan Li , Yan-Wei Li

Recent experimental realizations of liquid-liquid phase separation of active liquid crystals have offered an insight into the interaction between phase separation, ubiquitous in soft matter and biology, and chaotic active flows. In this…

软凝聚态物质 · 物理学 2025-04-23 Paarth Gulati , Fernando Caballero , M. Cristina Marchetti

The synergetic approach proposed here is based on characteristic instability of chemical bonding in the form of the bond wave considered as the spatiotemporal correlation between the elementary acts of bond exchange. In frames of the model,…

材料科学 · 物理学 2024-07-02 Elena A. Chechetkina

Tissue fluidity regulates many critical biological processes, including embryonic development, wound healing, and cancer metastasis. In confluent epithelia, where cell packing fraction is effectively fixed, the prevailing paradigm…

生物物理 · 物理学 2026-03-09 Pradip K. Bera , Anh Q. Nguyen , Molly McCord , Dapeng Bi , Jacob Notbohm

A theory for the non-local stress in liquids captures the crossover from viscous to elastic correlations upon supercooling. It explains the emergence of long-ranged stress fields in glass which originate from the coupling of shear stress to…

软凝聚态物质 · 物理学 2022-05-03 Annette Zippelius , Matthias Fuchs

The fragile-to-strong glass transition is a fascinating phenomenon that still presents many theoretical and experimental challenges. A major one is how to tune the fragility of a glass-forming liquid. Here, we study a two-dimensional (2D)…

Melt supercooling leads to glass formation. Liquid-to-liquid phase transitions are observed depending on thermal paths. Viscosity, density and surface tension thermal dependences measured at heating and subsequent cooling show hysteresis…

材料科学 · 物理学 2016-12-21 Robert F. Tournier

Based on experimental evidences we present a phenomenological description of the thermal glass transition as a dynamical phase transition. Different susceptibilities calculated on the basis of this description are in good qualitative…

无序系统与神经网络 · 物理学 2016-08-16 J. K. Krüger , J. Petersson , J. Baller , M. Henkel

We propose that the dynamics of supercooled liquids and the formation of glasses can be understood from the existence of a zero temperature dynamical critical point. To support our proposal, we derive from simple physical assumptions a…

软凝聚态物质 · 物理学 2009-11-10 Stephen Whitelam , Ludovic Berthier , Juan P. Garrahan

Glasses acquire their solid-like properties by cooling from the supercooled liquid via a continuous transition known as the glass transition. Recent research on soft glasses indicates that besides temperature, another route to liquify…

软凝聚态物质 · 物理学 2015-07-17 D. V. Denisov , M. T. Dang , B. Struth , A. Zaccone , G. H. Wegdam , P. Schall
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