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Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…

机器学习 · 计算机科学 2021-08-03 Amish Mittal , Sourav Sahoo , Arnhav Datar , Juned Kadiwala , Hrithwik Shalu , Jimson Mathew

Medical patient data is always multimodal. Images, text, age, gender, histopathological data are only few examples for different modalities in this context. Processing and integrating this multimodal data with deep learning based methods is…

人工智能 · 计算机科学 2025-09-11 Christian Gapp , Elias Tappeiner , Martin Welk , Rainer Schubert

Magnetic Resonance Imaging (MRI) plays a pivotal role in the early diagnosis and monitoring of Alzheimer's disease (AD). However, the subtle structural variations in brain MRI scans often pose challenges for conventional deep learning…

图像与视频处理 · 电气工程与系统科学 2025-12-22 Faisal Ahmed

Multi-modal learning has shown exceptional performance in various tasks, especially in medical applications, where it integrates diverse medical information for comprehensive diagnostic evidence. However, there still are several challenges…

机器学习 · 计算机科学 2024-11-19 Lin Fan , Yafei Ou , Cenyang Zheng , Pengyu Dai , Tamotsu Kamishima , Masayuki Ikebe , Kenji Suzuki , Xun Gong

Generative approaches for cross-modality transformation have recently gained significant attention in neuroimaging. While most previous work has focused on case-control data, the application of generative models to disorder-specific…

神经元与认知 · 定量生物学 2024-05-10 Reihaneh Hassanzadeh , Anees Abrol , Hamid Reza Hassanzadeh , Vince D. Calhoun

Recent studies have shown that integrating multimodal data fusion techniques for imaging and genetic features is beneficial for the etiological analysis and predictive diagnosis of Alzheimer's disease (AD). However, there are several…

基因组学 · 定量生物学 2025-06-03 Lina Qin , Cheng Zhu , Chuqi Zhou , Yukun Huang , Jiayi Zhu , Ping Liang , Jinju Wang , Yixing Huang , Cheng Luo , Dezhong Yao , Ying Tan

Healthcare data now span EHRs, medical imaging, genomics, and wearable sensors, but most diagnostic models still process these modalities in isolation. This limits their ability to capture early, cross-modal disease signatures. This paper…

机器学习 · 计算机科学 2025-12-18 Md Talha Mohsin , Ismail Abdulrashid

Early and accurate detection of Alzheimer's disease (AD) is crucial for enabling timely intervention and improving outcomes. However, developing reliable machine learning (ML) models for AD diagnosis is challenging due to limited labeled…

机器学习 · 计算机科学 2025-11-27 Abolfazl Moslemi , Hossein Peyvandi

A plethora of deep learning models have been developed for the task of Alzheimer's disease classification from brain MRI scans. Many of these models report high performance, achieving three-class classification accuracy of up to 95%.…

计算机视觉与模式识别 · 计算机科学 2019-04-18 Ziqiang Guan , Ritesh Kumar , Yi Ren Fung , Yeahuay Wu , Madalina Fiterau

In the field of Alzheimer's disease diagnosis, segmentation and classification tasks are inherently interconnected. Sharing knowledge between models for these tasks can significantly improve training efficiency, particularly when training…

图像与视频处理 · 电气工程与系统科学 2024-09-13 Ke Chen , Yifeng Wang , Yufei Zhou , Haohan Wang

Alzheimer's Disease (AD) is a prevalent neurodegenerative condition where early detection is vital. Handwriting, often affected early in AD, offers a non-invasive and cost-effective way to capture subtle motor changes. State-of-the-art…

计算机视觉与模式识别 · 计算机科学 2024-10-15 Changqing Gong , Huafeng Qin , Mounîm A. El-Yacoubi

Medical data collected for diagnostic decisions are typically multimodal, providing comprehensive information on a subject. While computer-aided diagnosis systems can benefit from multimodal inputs, effectively fusing such data remains a…

计算机视觉与模式识别 · 计算机科学 2025-02-03 Qiuhui Chen , Yi Hong

Volumetric neuroimaging examinations like structural Magnetic Resonance Imaging (sMRI) are routinely applied to support the clinical diagnosis of dementia like Alzheimer's Disease (AD). Neuroradiologists examine 3D sMRI to detect and…

计算机视觉与模式识别 · 计算机科学 2024-07-23 Lisa Anita De Santi , Jörg Schlötterer , Meike Nauta , Vincenzo Positano , Christin Seifert

Alzheimer's disease (AD) constitutes a neurodegenerative disease with serious consequences to peoples' everyday lives, if it is not diagnosed early since there is no available cure. Alzheimer's is the most common cause of dementia, which…

计算与语言 · 计算机科学 2023-01-18 Loukas Ilias , Dimitris Askounis , John Psarras

FDG-PET reveals altered brain metabolism in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Some biomarkers derived from FDG-PET by computer-aided-diagnosis (CAD) technologies have been proved that they can…

图像与视频处理 · 电气工程与系统科学 2021-11-10 Wenju Cui , Caiying Yan , Zhuangzhi Yan , Yunsong Peng , Yilin Leng , Chenlu Liu , Shuangqing Chen , Xi Jiang

Alzheimer's disease (AD) is the most common neurodegenerative disease in older people. Despite considerable efforts to find a cure for AD, there is a 99.6% failure rate of clinical trials for AD drugs, likely because AD patients cannot…

机器学习 · 计算机科学 2019-03-25 Jack Albright

Alzheimer's Disease (AD) is the world leading cause of dementia, a progressively impairing condition leading to high hospitalization rates and mortality. To optimize the diagnostic process, numerous efforts have been directed towards the…

图像与视频处理 · 电气工程与系统科学 2025-01-20 Davide Coluzzi , Valentina Bordin , Massimo Walter Rivolta , Igor Fortel , Liang Zhang , Alex Leow , Giuseppe Baselli

In healthcare, the integration of multimodal data is pivotal for developing comprehensive diagnostic and predictive models. However, managing missing data remains a significant challenge in real-world applications. We introduce MARIA…

机器学习 · 计算机科学 2026-03-13 Camillo Maria Caruso , Paolo Soda , Valerio Guarrasi

Cognitive impairment detection through spontaneous speech is a promising avenue for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), where timely intervention can significantly improve patient outcomes. The…

声音 · 计算机科学 2025-02-19 Yifan Gao , Long Guo , Hong Liu

Alzheimer's disease (AD) constitutes a complex neurocognitive disease and is the main cause of dementia. Although many studies have been proposed targeting at diagnosing dementia through spontaneous speech, there are still limitations.…

计算与语言 · 计算机科学 2023-08-24 Loukas Ilias , Dimitris Askounis
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