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The Influenza virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Hemagglutinin (HA) gene of the virus can be a target for antiviral drug development…

定量方法 · 定量生物学 2021-08-11 Charalambos Chrysostomou , Floris Alexandrou , Mihalis A. Nicolaou , Huseyin Seker

The Influenza type A virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Haemagglutinin (HA) gene of the virus has the potential to be a target for…

定量方法 · 定量生物学 2021-02-16 Charalambos Chrysostomou , Harris Partaourides , Huseyin Seker

Influenza occurs every season and occasionally causes pandemics. Despite its low mortality rate, influenza is a major public health concern, as it can be complicated by severe diseases like pneumonia. A fast, accurate and low-cost method to…

定量方法 · 定量生物学 2022-08-01 Yanhua Xu , Dominik Wojtczak

Influenza poses a significant threat to public health, particularly among the elderly, young children, and people with underlying dis-eases. The manifestation of severe conditions, such as pneumonia, highlights the importance of preventing…

机器学习 · 计算机科学 2024-02-23 Yanhua Xu , Dominik Wojtczak

The rapid mutation of the influenza virus threatens public health. Reassortment among viruses with different hosts can lead to a fatal pandemic. However, it is difficult to detect the original host of the virus during or after an outbreak…

计算与语言 · 计算机科学 2023-11-21 Yanhua Xu , Dominik Wojtczak

The influenza virus hemagglutinin is an important part of the virus attachment to the host cells. The hemagglutinin proteins are one of the genetic regions of the virus with a high potential for mutations. Due to the importance of…

A central challenge in every field of biology is to use existing measurements to predict the outcomes of future experiments. In this work, we consider the wealth of antibody inhibition data against variants of the influenza virus. Due to…

定量方法 · 定量生物学 2023-07-27 Tal Einav , Rong Ma

Identifying viral pathogens and characterizing their transmission is essential to developing effective public health measures in response to a pandemic. Phylogenetics, though currently the most popular tool used to characterize the likely…

定量方法 · 定量生物学 2015-05-28 Anil Raj , Michael Dewar , Gustavo Palacios , Raul Rabadan , Chris H. Wiggins

The evolution of the hemagglutinin amino acids sequences of Influenza A virus is studied by a method based on an informational metrics, originally introduced by Rohlin for partitions in abstract probability spaces. This metrics does not…

种群与进化 · 定量生物学 2015-06-03 Raffaella Burioni , Riccardo Scalco , Mario Casartelli

A principal component analysis of a multiple sequence alignement of hemagglutinin sequences of subtype H1 has been performed, the sequences being encoded using the amino-acid property that maximizes the weight of the major component. In the…

生物大分子 · 定量生物学 2018-03-16 Yves-Henri Sanejouand

Avian Influenza breakouts cause millions of dollars in damage each year globally, especially in Asian countries such as China and South Korea. The impact magnitude of a breakout directly correlates to time required to fully understand the…

定量方法 · 定量生物学 2018-02-27 Woo Yong Choi , Kyu Ye Song , Chan Woo Lee

Influenza, an infectious disease, causes many deaths worldwide. Predicting influenza victims during epidemics is an important task for clinical, hospital, and community outbreak preparation. On-line user-generated contents (UGC), primarily…

计算机与社会 · 计算机科学 2021-04-15 Taichi Murayama , Nobuyuki Shimizu , Sumio Fujita , Shoko Wakamiya , Eiji Aramaki

Public health surveillance systems often fail to detect emerging infectious diseases, particularly in resource limited settings. By integrating relevant clinical and internet-source data, we can close critical gaps in coverage and…

应用统计 · 统计学 2019-03-05 Kai Liu , Ravi Srinivasan , Lauren Ancel Meyers

Influenza A is responsible for 290,000 to 650,000 respiratory deaths a year, though this estimate is an improvement from years past due to improvements in sanitation, healthcare practices, and vaccination programs. In this study, we perform…

机器学习 · 计算机科学 2025-07-29 Edmund F. Agyemang , Hansapani Rodrigo , Vincent Agbenyeavu

We propose an approach based on a combination of physical, chemical, and mathematical methods to identify and characterize virulent influenza A viruses (IAVs) through the analysis of the hemagglutinin protein. These methods include the…

定量方法 · 定量生物学 2024-11-08 Meitner Cadena , Alejandro Yerovi

Influenza is an infectious disease with the potential to become a pandemic, and hence, forecasting its prevalence is an important undertaking for planning an effective response. Research has found that web search activity can be used to…

机器学习 · 计算机科学 2021-05-27 Michael Morris , Peter Hayes , Ingemar J. Cox , Vasileios Lampos

Determining phenotype from genetic data is a fundamental challenge. Influenza A viruses undergo rapid antigenic drift and identification of emerging antigenic variants is critical to the vaccine selection process. Using former seasonal…

High order structures (cavities and cliques) of the gene network of influenza A virus reveal tight associations among viruses during evolution and are key signals that indicate viral cross-species infection and cause pandemics. As…

基因组学 · 定量生物学 2022-11-08 Junjie Li , Jietong Zhao , Yanqing Su , Jiahao Shen , Yaohua Liu , Xinyue Fan , Zheng Kou

Predicting cross-immunity between viral strains is vital for public health surveillance and vaccine development. Traditional neural network methods, such as BiLSTM, could be ineffective due to the lack of lab data for model training and the…

计算工程、金融与科学 · 计算机科学 2023-10-18 Yiming Du , Zhuotian Li , Qian He , Thomas Wetere Tulu , Kei Hang Katie Chan , Lin Wang , Sen Pei , Zhanwei Du , Xiao-Ke Xu , Xiao Fan Liu

H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with…

种群与进化 · 定量生物学 2012-04-30 Keyao Pan , Krystina C. Subieta , Michael W. Deem
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