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While spatial dose conformity delivered to a target volume has been pushed to its practical limits with advanced treatment planning and delivery, investigations in novel temporal dose delivery are unfolding new mechanisms. Recent advances…

UHE particle detection using the lunar Cherenkov technique aims to detect nanosecond pulses of Cherenkov emission which are produced during UHE cosmic ray and neutrino interactions in the Moon's regolith. These pulses will reach Earth-based…

高能天体物理现象 · 物理学 2015-05-27 R. McFadden , R. Ekers , P. Roberts

Using kilometric arrays of air Cherenkov telescopes, intensity interferometry may increase the spatial resolution in optical astronomy by an order of magnitude, enabling images of rapidly rotating stars with structures in their…

天体物理仪器与方法 · 物理学 2015-06-05 Dainis Dravins , Stephan LeBohec , Hannes Jensen , Paul D. Nuñez

FLASH-RT has proven beneficial in preclinical studies. However, the lack of accurate real time 2D dosimetry is a limiting factor. In this work, an innovative solution for 2D real time dosimetry in UHDR electron beams is presented. The…

Background: The normal tissue sparing effect of ultra-high dose rate irradiation (>40 Gy/s, UHDR), as compared to conventional dose rate (CONV), has attracted significant research interest for FLASH radiotherapy (RT). Accurate, dose rate…

医学物理 · 物理学 2025-07-08 Lixiang Guo , Banghao Zhou , Yi-Chun Tsai , Kai Jiang , Viktor Iakovenko , Ken Kang-Hsin Wang

The increasing interest in FLASH-RT has lead to the conversion of linear accelerators to enable ultra-high dose rate (UHDR) beams for preclinical research. Dosimetry hereof remains challenging with several crucial aspects missing. This work…

Beam diagnostics are crucial for smooth accelerator operations. Many techniques rely on instrumentation in which the beam properties are significantly affected by the measurement. Novel approaches aim to use Cherenkov Diffraction Radiation…

Lunar Cherenkov experiments aim to detect nanosecond pulses of Cherenkov emission produced during UHE cosmic ray or neutrino interactions in the lunar regolith. Pulses from these interactions are dispersed, and therefore reduced in…

天体物理仪器与方法 · 物理学 2013-06-04 Rebecca McFadden , Ron Ekers , Justin Bray

VERITAS employs a 12m segmented mirror and pixellated photomultiplier tube camera to detect the brief pulse of Cherenkov radiation produced by the extensive air shower initiated by a cosmic high-energy gamma ray. The VERITAS data…

天体物理学 · 物理学 2019-08-13 P. Cogan

We characterized the dosimetric properties of a clinical linear accelerator configured to deliver ultra-high dose rate (UHDR) irradiation to mice and cell-culture FLASH radiobiology experiments. UHDR electron beams were controlled by a…

The Lunar Cherenkov technique is a promising method for UHE neutrino and cosmic ray detection which aims to detect nanosecond radio pulses produced during particle interactions in the Lunar regolith. For low frequency experiments, such as…

天体物理仪器与方法 · 物理学 2015-06-16 Rebecca McFadden , Olaf Scholten , Maaijke Mevius

Ultra-high dose rate electron sources require dose rate independent dosimeters and a calibrated dose control system for accurate delivery. In this study, we developed a single-pulse dose monitoring and a real-time dose-based control system…

Purpose: In this study, procedures were developed to achieve efficient reversible conversion of a clinical linear accelerator (LINAC) and deliver electron FLASH (eFLASH) or conventional beams to the treatment room isocenter. Material &…

Objective: While FLASH radiotherapy is recognized for short-term normal tissue sparing, its durability in late-responding organs remains uncertain, limiting clinical adoption. With its clinical importance and steep dose-response, the spinal…

In this exploratory simulation study, we compare the event-progenitor classification potential of a variety of measurable parameters of atmospheric Cherenkov pulses which are produced by ultra-high energy (UHE) gamma-ray and hadron…

天体物理学 · 物理学 2009-11-07 A. Razdan , A. Haungs , H. Rebel , C. L. Bhat

Purpose: Cherenkov radiation carries the potential of direct in-water dose measurements, but its precision is currently limited by a strong anisotropy. Taking advantage of polarization imaging, this work proposes a new approach for high…

医学物理 · 物理学 2022-10-12 Emily Cloutier , Louis Archambault , Luc Beaulieu

Ground-based Cherenkov telescopes, although typically inoperative during moonlit nights for gamma-ray observations, offer a valuable opportunity for secondary scientific applications through Intensity Interferometry (II). Recent…

天体物理仪器与方法 · 物理学 2025-08-14 Km Nitu Rai , Prasenjit Saha , Subrata Sarangi

Kilometric-scale optical imagers seem feasible to realize by intensity interferometry, using telescopes primarily erected for measuring Cherenkov light induced by gamma rays. Planned arrays envision 50--100 telescopes, distributed over some…

天体物理仪器与方法 · 物理学 2010-09-30 Hannes Jensen , Dainis Dravins , Stephan LeBohec , Paul D. Nuñez

High angular resolution observations at optical wavelengths provide valuable insights in stellar astrophysics, directly measuring fundamental stellar parameters, and probing stellar atmospheres, circumstellar disks, elongation of rapidly…

Cherenkov imaging enables real-time visualization of megavoltage X-ray or electron beam delivery to the patient during Radiation Therapy (RT). Bio-morphological features, such as vasculature, seen in these images are patient-specific…

图像与视频处理 · 电气工程与系统科学 2024-09-10 Shiru Wang , Yao Chen , Lesley A. Jarvis , Yucheng Tang , David J. Gladstone , Kimberley S. Samkoe , Brian W. Pogue , Petr Bruza , Rongxiao Zhang
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