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Multi-omic datasets offer opportunities for improved biomarker discovery in cancer research, but their high dimensionality and limited sample sizes make identifying compact and effective biomarker panels challenging. Feature selection in…

基因组学 · 定量生物学 2026-04-02 Luca Cattelani , Vittorio Fortino

Cancer prognosis is a critical task that involves predicting patient outcomes and survival rates. To enhance prediction accuracy, previous studies have integrated diverse data modalities, such as clinical notes, medical images, and genomic…

机器学习 · 计算机科学 2025-02-04 Jie Peng , Shuang Zhou , Longwei Yang , Yiran Song , Mohan Zhang , Kaixiong Zhou , Feng Xie , Mingquan Lin , Rui Zhang , Tianlong Chen

Masked Autoencoders (MAEs) have emerged as a dominant strategy for self-supervised representation learning in natural images, where models are pre-trained to reconstruct masked patches with a pixel-wise mean squared error (MSE) between…

图像与视频处理 · 电气工程与系统科学 2025-07-16 Chetan Madan , Aarjav Satia , Soumen Basu , Pankaj Gupta , Usha Dutta , Chetan Arora

The Masked Autoencoder (MAE) has recently demonstrated effectiveness in pre-training Vision Transformers (ViT) for analyzing natural images. By reconstructing complete images from partially masked inputs, the ViT encoder gathers contextual…

图像与视频处理 · 电气工程与系统科学 2025-06-03 Badhan Kumar Das , Gengyan Zhao , Han Liu , Thomas J. Re , Dorin Comaniciu , Eli Gibson , Andreas Maier

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

计算机视觉与模式识别 · 计算机科学 2025-11-25 Samuel Stevens , Jacob Beattie , Tanya Berger-Wolf , Yu Su

COVID-19 has caused many deaths worldwide. The automation of the diagnosis of this virus is highly desired. Convolutional neural networks (CNNs) have shown outstanding classification performance on image datasets. To date, it appears that…

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

计算机视觉与模式识别 · 计算机科学 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

We have gained access to vast amounts of multi-omics data thanks to Next Generation Sequencing. However, it is challenging to analyse this data due to its high dimensionality and much of it not being annotated. Lack of annotated data is a…

机器学习 · 计算机科学 2022-10-04 Sayed Hashim , Karthik Nandakumar , Mohammad Yaqub

Masked autoencoders (MAE) have shown tremendous potential for self-supervised learning (SSL) in vision and beyond. However, point clouds from LiDARs used in automated driving are particularly challenging for MAEs since large areas of the 3D…

计算机视觉与模式识别 · 计算机科学 2025-02-28 Mohamed Abdelsamad , Michael Ulrich , Claudius Gläser , Abhinav Valada

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of…

机器学习 · 计算机科学 2023-12-06 Mark Peelen , Leila Bagheriye , Johan Kwisthout

Aims Late diagnosis of Oral Squamous Cell Carcinoma (OSCC) contributes significantly to its high global mortality rate, with over 50\% of cases detected at advanced stages and a 5-year survival rate below 50\% according to WHO statistics.…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Ajo Babu George , Sreehari J R Ajo Babu George , Sreehari J R Ajo Babu George , Sreehari J R

Survival analysis is a task to model the time until an event of interest occurs, widely used in clinical and biomedical research. A key challenge is to model patient heterogeneity while also adapting risk predictions to both individual…

机器学习 · 计算机科学 2025-10-31 Hyeonjun Lee , Hyungseob Shin , Gunhee Nam , Hyeonsoo Lee

Objectives: Lung cancer poses a significant global health challenge, necessitating improved prognostic methods for personalized treatment. This study introduces a censor-aware semi-supervised learning (SSL) framework that integrates…

Masked autoencoders (MAEs) have displayed significant potential in the classification and semantic segmentation of medical images in the last year. Due to the high similarity of human tissues, even slight changes in medical images may…

计算机视觉与模式识别 · 计算机科学 2023-05-11 Jiawei Mao , Shujian Guo , Yuanqi Chang , Xuesong Yin , Binling Nie

In this paper we propose Structuring AutoEncoders (SAE). SAEs are neural networks which learn a low dimensional representation of data which are additionally enriched with a desired structure in this low dimensional space. While traditional…

机器学习 · 计算机科学 2019-08-20 Marco Rudolph , Bastian Wandt , Bodo Rosenhahn

According to GLOBOCAN 2020, prostate cancer is the second most common cancer in men worldwide and the fourth most prevalent cancer overall. For pathologists, grading prostate cancer is challenging, especially when discriminating between…

图像与视频处理 · 电气工程与系统科学 2023-03-22 Zahra Tabatabaei , Adrian colomer , Kjersti Engan , Javier Oliver , Valery Naranjo

With the advanced imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

应用统计 · 统计学 2020-12-10 Esteban Fernández Morales , Cong Zhang , Guanghua Xiao , Chul Moon , Qiwei Li

Steered-Mixtures-of-Experts (SMoE) models provide sparse, edge-aware representations, applicable to many use-cases in image processing. This includes denoising, super-resolution and compression of 2D- and higher dimensional pixel data.…

图像与视频处理 · 电气工程与系统科学 2022-07-26 Elvira Fleig , Jonas Geistert , Erik Bochinski , Rolf Jongebloed , Thomas Sikora

Recent advances in representation learning have successfully leveraged the underlying domain-specific structure of data across various fields. However, representing diverse and complex entities stored in tabular format within a latent space…

机器学习 · 计算机科学 2025-02-05 Jan Henrik Bertrand , David B. Hoffmann , Jacopo Pio Gargano , Laurent Mombaerts , Jonathan Taws

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

统计方法学 · 统计学 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon