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Early diagnosis of lung cancer is a key intervention for the treatment of lung cancer computer aided diagnosis (CAD) can play a crucial role. However, most published CAD methods treat lung cancer diagnosis as a lung nodule classification…

图像与视频处理 · 电气工程与系统科学 2022-10-12 Junhua Chen , Haiyan Zeng , Chong Zhang , Zhenwei Shi , Andre Dekker , Leonard Wee , Inigo Bermejo

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for…

计算机视觉与模式识别 · 计算机科学 2024-05-06 Diogo J. Araújo , M. Rita Verdelho , Alceu Bissoto , Jacinto C. Nascimento , Carlos Santiago , Catarina Barata

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

计算机视觉与模式识别 · 计算机科学 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations. Often, this approach directly applies "natural image…

Advances in medical imaging and deep learning have propelled progress in whole slide image (WSI) analysis, with multiple instance learning (MIL) showing promise for efficient and accurate diagnostics. However, conventional MIL models often…

计算机视觉与模式识别 · 计算机科学 2025-05-19 Xianrui Li , Yufei Cui , Jun Li , Antoni B. Chan

A new multi-attention based method for solving the MIL problem (MAMIL), which takes into account the neighboring patches or instances of each analyzed patch in a bag, is proposed. In the method, one of the attention modules takes into…

机器学习 · 计算机科学 2021-12-14 Andrei V. Konstantinov , Lev V. Utkin

Multiple Instance Learning is the predominant method for Whole Slide Image classification in digital pathology, enabling the use of slide-level labels to supervise model training. Although MIL eliminates the tedious fine-grained annotation…

计算机视觉与模式识别 · 计算机科学 2025-05-28 Chen Shu , Boyu Fu , Yiman Li , Ting Yin , Wenchuan Zhang , Jie Chen , Yuhao Yi , Hong Bu

In the field of computational pathology, the use of decision support systems powered by state-of-the-art deep learning solutions has been hampered by the lack of large labeled datasets. Until recently, studies relied on datasets in the…

计算机视觉与模式识别 · 计算机科学 2018-10-01 Gabriele Campanella , Vitor Werneck Krauss Silva , Thomas J. Fuchs

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

计算机视觉与模式识别 · 计算机科学 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

Traditional supervised learning tasks require a label for every instance in the training set, but in many real-world applications, labels are only available for collections (bags) of instances. This problem setting, known as multiple…

计算机视觉与模式识别 · 计算机科学 2023-05-23 Georg Wölflein , Lucie Charlotte Magister , Pietro Liò , David J. Harrison , Ognjen Arandjelović

Multi-instance learning (MIL) is an effective paradigm for whole-slide pathological images (WSIs) classification to handle the gigapixel resolution and slide-level label. Prevailing MIL methods primarily focus on improving the feature…

计算机视觉与模式识别 · 计算机科学 2023-03-14 Tiancheng Lin , Zhimiao Yu , Hongyu Hu , Yi Xu , Chang Wen Chen

Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

图像与视频处理 · 电气工程与系统科学 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

Whole Slide Images (WSIs) are high-resolution digital scans widely used in medical diagnostics. WSI classification is typically approached using Multiple Instance Learning (MIL), where the slide is partitioned into tiles treated as…

计算机视觉与模式识别 · 计算机科学 2025-11-25 Sharon Peled , Yosef E. Maruvka , Moti Freiman

Multiple instance learning (MIL) is the standard approach for whole-slide image (WSI) classification and survival prediction, where attention-based models ag gregate patch features into slide-level predictions. These models treat attention…

计算机视觉与模式识别 · 计算机科学 2026-05-19 Xiangyu Li , Ran Su

Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of…

计算机视觉与模式识别 · 计算机科学 2024-08-13 Thiziri Nait Saada , Valentina Di Proietto , Benoit Schmauch , Katharina Von Loga , Lucas Fidon

Multiple Instance Learning (MIL) gains popularity in many real-life machine learning applications due to its weakly supervised nature. However, the corresponding effort on explaining MIL lags behind, and it is usually limited to presenting…

In Multiple Instance Learning (MIL), models are trained using bags of instances, where only a single label is provided for each bag. A bag label is often only determined by a handful of key instances within a bag, making it difficult to…

机器学习 · 计算机科学 2022-03-16 Joseph Early , Christine Evers , Sarvapali Ramchurn

Multiple instance learning (MIL) is a powerful tool to solve the weakly supervised classification in whole slide image (WSI) based pathology diagnosis. However, the current MIL methods are usually based on independent and identical…

计算机视觉与模式识别 · 计算机科学 2021-11-02 Zhuchen Shao , Hao Bian , Yang Chen , Yifeng Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang