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The statistical analysis of clinical trials is often complicated by missing data. Patients sometimes experience intercurrent events (ICEs), which usually (although not always) lead to missing subsequent outcome measurements for such…

统计方法学 · 统计学 2025-07-03 Brendah Nansereko , Marcel Wolbers , James Carpenter , Jonathan Bartlett

We propose a family of novel hierarchical Bayesian deep auto-encoder models capable of identifying disentangled factors of variability in data. While many recent attempts at factor disentanglement have focused on sophisticated learning…

机器学习 · 计算机科学 2019-09-10 Minyoung Kim , Yuting Wang , Pritish Sahu , Vladimir Pavlovic

Accurate phase estimation at the edge of data segments is crucial for EEG applications such as EEG-TMS in offline and real-time data analysis. Our research evaluates the phase estimation performance of four commonly used methods…

神经元与认知 · 定量生物学 2026-04-03 Miriam Kirchhoff , Johanna Rösch , Maria Ermolova , Oskari Ahola , Sarah Harders , Juliana Hougland , Ulf Ziemann

Variational autoencoders (VAE) represent a popular, flexible form of deep generative model that can be stochastically fit to samples from a given random process using an information-theoretic variational bound on the true underlying…

机器学习 · 计算机科学 2019-10-08 Bin Dai , Yu Wang , John Aston , Gang Hua , David Wipf

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt…

统计方法学 · 统计学 2025-07-28 Luke Benz , Alexander Levis , Sebastien Haneuse

In healthcare, risk assessment of patient outcomes has been based on survival analysis for a long time, i.e. modeling time-to-event associations. However, conventional approaches rely on data from a single time-point, making them suboptimal…

机器学习 · 计算机科学 2026-02-20 Mine Öğretir , Miika Koskinen , Juha Sinisalo , Risto Renkonen , Harri Lähdesmäki

We propose a new statistical approach to obtain differential gene expression of non-detects in quantitative real-time PCR (qPCR) experiments through Bayesian hierarchical modeling. We propose to treat non-detects as non-random missing data,…

应用统计 · 统计学 2019-10-31 Valeriia Sherina , Matthew N. McCall , Tanzy M. T. Love

Estimating causal effects from large experimental and observational data has become increasingly prevalent in both industry and research. The bootstrap is an intuitive and powerful technique used to construct standard errors and confidence…

统计方法学 · 统计学 2023-02-07 Matthew Kosko , Lin Wang , Michele Santacatterina

Many statistical applications involve models for which it is difficult to evaluate the likelihood, but from which it is relatively easy to sample. Approximate Bayesian computation is a likelihood-free method for implementing Bayesian…

统计方法学 · 统计学 2017-11-29 Wentao Li , Paul Fearnhead

Building a scalable machine learning system for unsupervised anomaly detection via representation learning is highly desirable. One of the prevalent methods is using a reconstruction error from variational autoencoder (VAE) via maximizing…

机器学习 · 计算机科学 2020-05-08 Seonho Park , George Adosoglou , Panos M. Pardalos

Although artificial neural networks are often described as brain-inspired, their representations typically rely on continuous activations, such as the continuous latent variables in variational autoencoders (VAEs), which limits their…

机器学习 · 计算机科学 2026-04-09 Yixuan Zhang , Jinhao Sheng , Wenxin Zhang , Quyu Kong , Feng Zhou

The interventional effects approach to causal mediation analysis is increasingly common in epidemiologic research, given its potential to address policy-relevant questions about hypothetical mediator interventions. Multiple imputation (MI)…

Estimating the causal effects of an intervention from high-dimensional observational data is difficult due to the presence of confounding. The task is often complicated by the fact that we may have a systematic missingness in our data at…

机器学习 · 统计学 2020-03-02 Sonali Parbhoo , Mario Wieser , Aleksander Wieczorek , Volker Roth

The combination of machine learning models with physical models is a recent research path to learn robust data representations. In this paper, we introduce p$^3$VAE, a variational autoencoder that integrates prior physical knowledge about…

计算机视觉与模式识别 · 计算机科学 2025-02-27 Romain Thoreau , Laurent Risser , Véronique Achard , Béatrice Berthelot , Xavier Briottet

Event argument extraction (EAE) aims to extract arguments with given roles from texts, which have been widely studied in natural language processing. Most previous works have achieved good performance in specific EAE datasets with dedicated…

计算与语言 · 计算机科学 2022-09-07 Jie Zhou , Qi Zhang , Qin Chen , Liang He , Xuanjing Huang

Ideally, a meta-analysis will summarize data from several unbiased studies. Here we consider the less than ideal situation in which contributing studies may be compromised by measurement error. Measurement error affects every study design,…

Methods to handle missing data have been extensively explored in the context of estimation and descriptive studies, with multiple imputation being the most widely used method in clinical research. However, in the context of clinical risk…

统计方法学 · 统计学 2024-11-25 Junhui Mi , Rahul D. Tendulkar , Sarah M. C. Sittenfeld , Sujata Patil , Emily C. Zabor

Data-driven reduced-order models based on autoencoders generally lack interpretability compared to classical methods such as the proper orthogonal decomposition. More interpretability can be gained by disentangling the latent variables and…

机器学习 · 计算机科学 2025-02-21 Henning Schwarz , Pyei Phyo Lin , Jens-Peter M. Zemke , Thomas Rung

The estimation of coverage probabilities, and in particular of the missing mass, is a classical statistical problem with applications in numerous scientific fields. In this paper, we study this problem in relation to randomized data…

统计方法学 · 统计学 2022-09-07 Stefano Favaro , Matteo Sesia

We consider parameter estimation and inference when data feature blockwise, non-monotone missingness. Our approach, rooted in semiparametric theory and inspired by prediction-powered inference, leverages off-the-shelf AI (predictive or…

统计方法学 · 统计学 2025-09-30 Qi Xu , Lorenzo Testa , Jing Lei , Kathryn Roeder