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Subretinal injection is a critical procedure for delivering therapeutic agents to treat retinal diseases such as age-related macular degeneration (AMD). However, retinal motion caused by physiological factors such as respiration and…

A physics-informed neural network (PINN) uses physics-augmented loss functions, e.g., incorporating the residual term from governing partial differential equations (PDEs), to ensure its output is consistent with fundamental physics laws.…

Convolutional neural networks (CNNs) have shown exceptional performance for a range of medical imaging tasks. However, conventional CNNs are not able to explain their reasoning process, therefore limiting their adoption in clinical…

A central challenge in neuroscience is to understand neural computations and circuit mechanisms that underlie the encoding of ethologically relevant, natural stimuli. In multilayered neural circuits, nonlinear processes such as synaptic…

In this study, we tackle a modern research challenge within the field of perceptual brain decoding, which revolves around synthesizing images from EEG signals using an adversarial deep learning framework. The specific objective is to…

Hyperspectral imaging is a powerful bioimaging tool which can uncover novel insights, thanks to its sensitivity to the intrinsic properties of materials. However, this enhanced contrast comes at the cost of system complexity, constrained by…

In this paper, we introduce a new deep learning framework for discovering the phase field models from existing image data. The new framework embraces the approximation power of physics informed neural networks (PINN), and the computational…

We present an interactive approach to train a deep neural network pixel classifier for the segmentation of neuronal structures. An interactive training scheme reduces the extremely tedious manual annotation task that is typically required…

Learning binary representation is essential to large-scale computer vision tasks. Most existing algorithms require a separate quantization constraint to learn effective hashing functions. In this work, we present Direct Binary Embedding…

This paper reviews recent studies in understanding neural-network representations and learning neural networks with interpretable/disentangled middle-layer representations. Although deep neural networks have exhibited superior performance…

Retinal implants are a promising treatment option for degenerative retinal disease. While numerous models have been developed to simulate the appearance of elicited visual percepts ("phosphenes"), these models often either focus solely on…

Deep learning approaches have shown promising performance for compressed sensing-based Magnetic Resonance Imaging. While deep neural networks trained with mean squared error (MSE) loss functions can achieve high peak signal to noise ratio,…

Deep learning is currently playing a crucial role toward higher levels of artificial intelligence. This paradigm allows neural networks to learn complex and abstract representations, that are progressively obtained by combining simpler…

In various engineering and applied science applications, repetitive numerical simulations of partial differential equations (PDEs) for varying input parameters are often required (e.g., aircraft shape optimization over many design…

Implicit Neural Representation (INR), which utilizes a neural network to map coordinate inputs to corresponding attributes, is causing a revolution in the field of signal processing. However, current INR techniques suffer from a restricted…

Artificial Neural Networks are computational network models inspired by signal processing in the brain. These models have dramatically improved the performance of many learning tasks, including speech and object recognition. However,…

Although deep learning has solved difficult problems in visual pattern recognition, it is mostly successful in tasks where there are lots of labeled training data available. Furthermore, the global back-propagation based training rule and…

The interpretability of neural networks (NNs) is a challenging but essential topic for transparency in the decision-making process using machine learning. One of the reasons for the lack of interpretability is random weight initialization,…

Blind deconvolution is a challenging problem, but in low-light it is even more difficult. Existing algorithms, both classical and deep-learning based, are not designed for this condition. When the photon shot noise is strong, conventional…

Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep…