相关论文: Functional Clustering of Neuronal Signals with FMM…

We propose a construction for joint feature learning and clustering of multichannel extracellular electrophysiological data across multiple recording periods for action potential detection and discrimination ("spike sorting"). Our…

The modelling of action potentials from extracellular recordings, or spike sorting, is a rich area of neuroscience research in which latent variable models are often used. Two such models, Overfitted Finite Mixture models (OFMs) and…

With advances in neural recording techniques, neuroscientists are now able to record the spiking activity of many hundreds of neurons simultaneously, and new statistical methods are needed to understand the structure of this large-scale…

We introduce the spiked mixture model (SMM) to address the problem of estimating a set of signals from many randomly scaled and noisy observations. Subsequently, we design a novel expectation-maximization (EM) algorithm to recover all…

Spike sorting plays an irreplaceable role in understanding brain codes. Traditional spike sorting technologies perform feature extraction and clustering separately after spikes are well detected. However, it may often cause many additional…

Probabilistic clustering models (or equivalently, mixture models) are basic building blocks in countless statistical models and involve latent random variables over discrete spaces. For these models, posterior inference methods can be…

Any clustering algorithm must synchronously learn to model the clusters and allocate data to those clusters in the absence of labels. Mixture model-based methods model clusters with pre-defined statistical distributions and allocate data to…

In this paper, we analyze electroencephalograms (EEG) which are recordings of brain electrical activity. We develop new clustering methods for identifying synchronized brain regions, where the EEGs show similar oscillations or waveforms…

Data-driven spatial filtering algorithms optimize scores such as the contrast between two conditions to extract oscillatory brain signal components. Most machine learning approaches for filter estimation, however, disregard within-trial…

Data represented as covariance-type matrices arise in many fields, including brain functional connectivity and diffusion tensor imaging. We develop the MFM-Wishart, a Bayesian model-based clustering approach for such data that combines…

Spike sorting is an essential process in neural recording, which identifies and separates electrical signals from individual neurons recorded by electrodes in the brain, enabling researchers to study how specific neurons communicate and…

Clustering mixed-type data remains a major challenge in biomedical research to uncover clinically meaningful subgroups within heterogeneous patient populations. Most existing clustering methods impose restrictive assumptions like local…

This paper studies a factor modeling-based approach for clustering high-dimensional data generated from a mixture of strongly correlated variables. Statistical modeling with correlated structures pervades modern applications in economics,…

Modern neural recording techniques allow neuroscientists to obtain spiking activity of multiple neurons from different brain regions over long time periods, which requires new statistical methods to be developed for understanding structure…

Purpose: Functional Magnetic Resonance Imaging (fMRI) data acquired through resting-state studies have been used to obtain information about the spontaneous activations inside the brain. One of the approaches for analysis and interpretation…

Recent advancements in miniaturized fluorescence microscopy have made it possible to investigate neuronal responses to external stimuli in awake behaving animals through the analysis of intra-cellular calcium signals. An on-going challenge…

Functional connectivity (FC) derived from functional magnetic resonance imaging (fMRI) data offers vital insights for understanding brain function and neurological and psychiatric disorders. Unsupervised clustering methods are desired to…

Clustering data objects into homogeneous groups is one of the most important tasks in data mining. Spectral clustering is arguably one of the most important algorithms for clustering, as it is appealing for its theoretical soundness and is…

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

The problem of complex data analysis is a central topic of modern statistical science and learning systems and is becoming of broader interest with the increasing prevalence of high-dimensional data. The challenge is to develop statistical…