相关论文: Hybrid in-beam PET- and Compton prompt-gamma imagi…
Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and…
PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements…
The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning the proton range and target composition. In order to image prompt gamma we present different approaches. The…
Modern PET systems reach a spatial resolution of 3-10 mm. A disadvantage of this technique is the diffusion of the positron before its decay with a typical range of ca. 1 mm (depending on its energy). This motion and Compton scattering of…
Prompt Gamma Timing (PGT) is a promising technique for in vivo range verification in particle therapy, exploiting the time-of-flight between primary particles and prompt gamma rays emitted by nuclear interactions. PGT distribution is highly…
In this work, we report on the advantageous aspects of the i-TED Compton imager for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that…
Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…
We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection system consists of eight LaBr3 scintillators and a tungsten collimator,…
Range uncertainties in proton therapy hamper treatment precision. Prompt gamma-rays were suggested 16 years ago for real-time range verification, and have already shown promising results in clinical studies with collimated cameras.…
Background and purpose: In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. PET distributions obtained during various treatment sessions can…
For the in vivo range verification in proton therapy, it has been tried to measure the spatial distribution of the prompt gammas generated by the proton-induced interactions with the close relationship with the proton dose distribution.…
Objective. Prompt-gamma imaging encompasses several approaches for online monitoring of beam range or deposited dose distribution in proton therapy. We test one of the imaging techniques - a coded mask approach - both experimentally and via…
Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…
In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a…
Charged particle beams are used in Particle Therapy (PT) to treat oncological patients due to their selective dose deposition in tissues and to their high biological effect in killing cancer cells with respect to photons and electrons used…
Monitoring the dose delivered during proton and carbon ion therapy is still a matter of research. Among the possible solutions, several exploit the measurement of the single photon emission from nuclear decays induced by the irradiation. To…
Recent studies of positron emission tomography (PET) devices have shown that the detection of polarization-correlated annihilation quanta can potentially reduce the background and creation of false lines of response (LORs) leading to…
Two major challenges in time-of-flight positron emission tomography (TOF-PET) are low spatial resolution and high radioactive dose to the patient, both of which result from limitations in detection technology rather than fundamental…
Compton scattering of a laser beam with a relativistic electron beam has been used to generate intense, highly polarized and nearly monoenergetic x-ray or gamma-ray beams at many facilities. The ability to predict the spatial, spectral and…
The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…