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The Gleason score is the most important prognostic marker for prostate cancer patients but suffers from significant inter-observer variability. We developed a fully automated deep learning system to grade prostate biopsies. The system was…

Introduction The focus of analyzing data from microarray experiments and extracting biological insight from such data has experienced a shift from identification of individual genes in association with a phenotype to that of biological…

基因组学 · 定量生物学 2015-08-10 Lei Zhang , Linlin Wang , Pu Tian , Suyan Tian

Melanoma is the most lethal form of skin cancer, and early detection is critical for improving patient outcomes. Although dermoscopy combined with deep learning has advanced automated skin-lesion analysis, progress is hindered by limited…

计算机视觉与模式识别 · 计算机科学 2026-03-17 Pei-Yu Lin , Yidan Shen , Neville Mathew , Renjie Hu , Siyu Huang , Courtney M. Queen , Cameron E. West , Ana Ciurea , George Zouridakis

This paper introduces a new approach to address the issue of class imbalance in graph neural networks (GNNs) for learning on graph-structured data. Our approach integrates imbalanced node classification and Bias-Variance Decomposition,…

机器学习 · 计算机科学 2025-02-26 Liang Yan , Gengchen Wei , Chen Yang , Shengzhong Zhang , Zengfeng Huang

The accurate automated classification of variable stars into their respective sub-types is difficult. Machine learning based solutions often fall foul of the imbalanced learning problem, which causes poor generalisation performance in…

天体物理仪器与方法 · 物理学 2020-03-18 Zafiirah Hosenie , Robert Lyon , Benjamin Stappers , Arrykrishna Mootoovaloo , Vanessa McBride

Quantitative analysis of large-scale data is often complicated by the presence of diverse subgroups, which reduce the accuracy of inferences they make on held-out data. To address the challenge of heterogeneous data analysis, we introduce…

机器学习 · 计算机科学 2021-09-01 Nazanin Alipourfard , Keith Burghardt , Kristina Lerman

Coarse-graining (CG) of molecular simulations simplifies the particle representation by grouping selected atoms into pseudo-beads and drastically accelerates simulation. However, such CG procedure induces information losses, which makes…

机器学习 · 计算机科学 2022-06-20 Wujie Wang , Minkai Xu , Chen Cai , Benjamin Kurt Miller , Tess Smidt , Yusu Wang , Jian Tang , Rafael Gómez-Bombarelli

In many applications, multivariate samples may harbor previously unrecognized heterogeneity at the level of conditional independence or network structure. For example, in cancer biology, disease subtypes may differ with respect to…

机器学习 · 统计学 2013-01-11 Steven M. Hill , Sach Mukherjee

Imbalanced classification on graphs is ubiquitous yet challenging in many real-world applications, such as fraudulent node detection. Recently, graph neural networks (GNNs) have shown promising performance on many network analysis tasks.…

机器学习 · 计算机科学 2021-06-08 Liang Qu , Huaisheng Zhu , Ruiqi Zheng , Yuhui Shi , Hongzhi Yin

Deep learning has been increasingly incorporated into various computational pathology applications to improve its efficiency, accuracy, and robustness. Although successful, most previous approaches for image classification have crucial…

图像与视频处理 · 电气工程与系统科学 2024-07-15 Anh Tien Nguyen , Jin Tae Kwak

Weakly supervised whole slide image classification is a key task in computational pathology, which involves predicting a slide-level label from a set of image patches constituting the slide. Constructing models to solve this task involves…

Accurate automatic organ segmentation is an important yet challenging problem for medical image analysis. The pancreas is an abdominal organ with very high anatomical variability. This inhibits traditional segmentation methods from…

计算机视觉与模式识别 · 计算机科学 2016-06-28 Holger R. Roth , Le Lu , Amal Farag , Andrew Sohn , Ronald M. Summers

The objective of graph coarsening is to generate smaller, more manageable graphs while preserving key information of the original graph. Previous work were mainly based on the perspective of spectrum-preserving, using some predefined…

人工智能 · 计算机科学 2025-06-25 Shuyin Xia , Guan Wang , Gaojie Xu , Sen Zhao , Guoyin Wang

Quantifying the phagocytosis of dynamic, unstained cells is essential for evaluating neurodegenerative diseases. However, measuring rapid cell interactions and distinguishing cells from background make this task very challenging when…

图像与视频处理 · 电气工程与系统科学 2024-03-14 Mehdi Ounissi , Morwena Latouche , Daniel Racoceanu

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

计算机视觉与模式识别 · 计算机科学 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

In recent literature, the Gaussian Graphical model (GGM; Lauritzen, 1996),a network of partial correlation coefficients, has been used to capture potential dynamic relationships between observed variables. The GGM can be estimated using…

统计方法学 · 统计学 2017-09-25 Sacha Epskamp

Grading of cancer is important to know the extent of its spread. Prior to grading, segmentation of glandular structures is important. Manual segmentation is a time consuming process and is subject to observer bias. Hence, an automated…

计算机视觉与模式识别 · 计算机科学 2017-08-16 Rohith AP , Salman S. Khan , Kumar Anubhav , Angshuman Paul

Gaussian Splatting (GS) has recently emerged as a promising technique for 3D object reconstruction, delivering high-quality rendering results with significantly improved reconstruction speed. As variants continue to appear, assessing the…

计算机视觉与模式识别 · 计算机科学 2026-03-10 Tianang Chen , Jian Jin , Shilv Cai , Zhuangzi Li , Weisi Lin

Gastric cancer is one of the most common cancers, which ranks third among the leading causes of cancer death. Biopsy of gastric mucosa is a standard procedure in gastric cancer screening test. However, manual pathological inspection is…

This paper studies the problem of class-imbalanced graph classification, which aims at effectively classifying the graph categories in scenarios with imbalanced class distributions. While graph neural networks (GNNs) have achieved…

机器学习 · 计算机科学 2024-12-31 Wei Ju , Zhengyang Mao , Siyu Yi , Yifang Qin , Yiyang Gu , Zhiping Xiao , Jianhao Shen , Ziyue Qiao , Ming Zhang