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Identifying and characterizing relationships between treatments, exposures, or other covariates and time-to-event outcomes has great significance in a wide range of biomedical settings. In research areas such as multi-center clinical…

统计方法学 · 统计学 2025-04-02 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Xianlu L. Peng , Jen Jen Yeh

We present ASCENDgpt, a transformer-based model specifically designed for cardiovascular risk prediction from longitudinal electronic health records (EHRs). Our approach introduces a novel phenotype-aware tokenization scheme that maps…

计算与语言 · 计算机科学 2025-09-08 Chris Sainsbury , Andreas Karwath

Recent advances in using quantitative ultrasound (QUS) methods have provided a promising framework to non-invasively and inexpensively monitor or predict the effectiveness of therapeutic cancer responses. One of the earliest steps in using…

计算机视觉与模式识别 · 计算机科学 2017-01-16 Mehrdad J. Gangeh , Hamid R. Tizhoosh , Kan Wu , Dun Huang , Hadi Tadayyon , Gregory J. Czarnota

Objective: To develop an effective and scalable individual-level patient cost prediction method by automatically learning hidden temporal patterns from multivariate time series data in patient insurance claims using a convolutional neural…

机器学习 · 计算机科学 2020-09-16 Mohammad Amin Morid , Olivia R. Liu Sheng , Kensaku Kawamoto , Samir Abdelrahman

The interpretation of the results of survival analysis often benefits from latent factor representations of baseline covariates. However, existing methods, such as Nonnegative Matrix Factorization (NMF), do not incorporate survival…

机器学习 · 计算机科学 2025-08-26 Paul Fogel , Christophe Geissler , George Luta

Treatment of cancer involves heterogeneous, complex care pathways. The relationship between these longitudinal trajectories, baseline mental health, and prognostic outcomes remains poorly understood. We introduce an interpretable…

Lung cancer is among the most common cancers in the United States, in terms of incidence and mortality. In 2009, it is estimated that more than 150,000 deaths will result from lung cancer alone. Genetic information is an extremely valuable…

应用统计 · 统计学 2011-08-10 Brent A. Johnson , Qi Long

Cancer is a number of related yet highly heterogeneous diseases. Correct identification of cancer subtypes is critical for clinical decisions. The advance in sequencing technologies has made it possible to study cancer based on abundant…

应用统计 · 统计学 2018-11-27 Xiaochun Chen , Honggang Wang , Donghui Yan

Breast cancer's complexity and variability pose significant challenges in understanding its progression and guiding effective treatment. This study aims to integrate protein sequence data with expression levels to improve the molecular…

生物大分子 · 定量生物学 2025-10-31 Hossein Sholehrasa , Majid Jaberi-Douraki

As much as data science is playing a pivotal role everywhere, healthcare also finds it prominent application. Breast Cancer is the top rated type of cancer amongst women; which took away 627,000 lives alone. This high mortality rate due to…

机器学习 · 计算机科学 2019-02-26 Vivek Kumar , Brojo Kishore Mishra , Manuel Mazzara , Dang N. H. Thanh , Abhishek Verma

Risk prediction is central to both clinical medicine and public health. While many machine learning models have been developed to predict mortality, they are rarely applied in the clinical literature, where classification tasks typically…

机器学习 · 统计学 2017-12-05 Maggie Makar , Marzyeh Ghassemi , David Cutler , Ziad Obermeyer

Purpose: We propose a general framework for quantifying predictive uncertainties of dose-related quantities and leveraging this information in a dose mimicking problem in the context of automated radiation therapy treatment planning.…

医学物理 · 物理学 2021-09-08 Tianfang Zhang , Rasmus Bokrantz , Jimmy Olsson

Monitoring the health status of patients in the Intensive Care Unit (ICU) is a critical aspect of providing superior care and treatment. The availability of large-scale electronic health records (EHR) provides machine learning models with…

人工智能 · 计算机科学 2023-05-05 Jun Wu , Xuesong Ye , Chengjie Mou , Weinan Dai

Bottom-Up Hidden Tree Markov Model is a highly expressive model for tree-structured data. Unfortunately, it cannot be used in practice due to the intractable size of its state-transition matrix. We propose a new approximation which lies on…

机器学习 · 计算机科学 2019-06-03 Daniele Castellana , Davide Bacciu

The integration of quantum machine learning with classical deep learning offers promising avenues for medical image analysis by mapping data into high-dimensional Hilbert spaces. However, effectively unifying these distinct paradigms…

计算机视觉与模式识别 · 计算机科学 2026-04-28 Yasmin Rodrigues Sobrinho , João Renato Ribeiro Manesco , João Paulo Papa

Cancer classification based on gene expression increases early diagnosis and recovery, but high-dimensional genes with a small number of samples are a major challenge. This work introduces a new hybrid quantum kernel support vector machine…

机器学习 · 计算机科学 2022-02-25 Essam H. Houssein , Zainab Abohashima , Mohamed Elhoseny , Waleed M. Mohamed

The transcriptomics of cancer tumors are characterized with tens of thousands of gene expression features. Patient prognosis or tumor stage can be assessed by machine learning techniques like supervised classification tasks given a gene…

机器学习 · 计算机科学 2020-04-13 Martin Palazzo , Patricio Yankilevich , Pierre Beauseroy

Breast cancer is the most commonly occurring cancer worldwide. This cancer caused 670,000 deaths globally in 2022, as reported by the WHO. Yet since health officials began routine mammography screening in age groups deemed at risk in the…

计算机视觉与模式识别 · 计算机科学 2025-06-17 Mahmudul Hasan

Accurate tumor classification is essential for selecting effective treatments, but current methods have limitations. Standard tumor grading, which categorizes tumors based on cell differentiation, is not recommended as a stand-alone…

计算机视觉与模式识别 · 计算机科学 2025-02-11 Marianne Abémgnigni Njifon , Tobias Weber , Viktor Bezborodov , Tyll Krueger , Dominic Schuhmacher

Tumor protein P53 is believed to be involved in over half of human cancers cases, the prediction of malignancies plays essential roles not only in advance detection for cancer, but also in discovering effective prevention and treatment of…

计算工程、金融与科学 · 计算机科学 2013-10-09 Ayad Ghany Ismaeel