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Gene expression datasets consist of thousand of genes with relatively small samplesizes (i.e. are large-$p$-small-$n$). Moreover, dependencies of various orders co-exist in the datasets. In the Undirected probabilistic Graphical Model (UGM)…

分子网络 · 定量生物学 2022-12-21 Catharina Elisabeth Graafland , José Manuel Gutiérrez

Desirable random graph models (RGMs) should (i) reproduce common patterns in real-world graphs (e.g., power-law degrees, small diameters, and high clustering), (ii) generate variable (i.e., not overly similar) graphs, and (iii) remain…

机器学习 · 计算机科学 2025-09-26 Fanchen Bu , Ruochen Yang , Paul Bogdan , Kijung Shin

Spatial transcriptomics technologies enable the measurement of gene expression with spatial context, providing opportunities to understand how gene regulatory networks vary across tissue regions. However, existing graphical models focus…

统计方法学 · 统计学 2025-12-15 Trisha Dawn , Yang Ni

Dynamic graphs are extensively employed for detecting anomalous behavior in nodes within the Internet of Things (IoT). Graph generative models are often used to address the issue of imbalanced node categories in dynamic graphs.…

机器人学 · 计算机科学 2024-12-13 Munan Li , Xianshi Su , Runze Ma , Tongbang Jiang , Zijian Li , Tony Q. S. Quek

We propose an interdependent random geometric graph (RGG) model for interdependent networks. Based on this model, we study the robustness of two interdependent spatially embedded networks where interdependence exists between geographically…

社会与信息网络 · 计算机科学 2018-06-08 Jianan Zhang , Edmund Yeh , Eytan Modiano

In the process of building (structural learning) a probabilistic graphical model from a set of observed data, the directional, cyclic dependencies between the random variables of the model are often found. Existing graphical models such as…

机器学习 · 计算机科学 2023-10-26 Oleksii Sirotkin

Recent studies have revealed that GNNs are vulnerable to adversarial attacks. Most existing robust graph learning methods measure model robustness based on label information, rendering them infeasible when label information is not…

机器学习 · 计算机科学 2023-06-09 Jihong Wang , Minnan Luo , Jundong Li , Ziqi Liu , Jun Zhou , Qinghua Zheng

We define Recurrent Gaussian Processes (RGP) models, a general family of Bayesian nonparametric models with recurrent GP priors which are able to learn dynamical patterns from sequential data. Similar to Recurrent Neural Networks (RNNs),…

Bayesian networks have been used as a mechanism to represent the joint distribution of multiple random variables in a flexible yet interpretable manner. One major challenge in learning the structure of a Bayesian network is how to model…

统计方法学 · 统计学 2022-12-06 Wanchuang Zhu , Ngoc Lan Chi Nguyen

Quantifying causal effects of exposures on outcomes, such as a treatment and a disease respectively, is a crucial issue in medical science for the administration of effective therapies. Importantly, any related causal analysis should…

统计方法学 · 统计学 2024-09-04 Federico Castelletti , Laura Ferrini

Unraveling the co-expression of genes across studies enhances the understanding of cellular processes. Inferring gene co-expression networks from transcriptome data presents many challenges, including spurious gene correlations, sample…

机器学习 · 统计学 2024-10-01 Teodora Pandeva , Martijs Jonker , Leendert Hamoen , Joris Mooij , Patrick Forré

Traditional model-based diagnosis relies on constructing explicit system models, a process that can be laborious and expertise-demanding. In this paper, we propose a novel framework that combines concepts of model-based diagnosis with deep…

人工智能 · 计算机科学 2023-10-11 Jan Lukas Augustin , Oliver Niggemann

Computer-aided diagnosis (CADx) has become vital in medical imaging, but automated systems often struggle to replicate the nuanced process of clinical interpretation. Expert diagnosis requires a comprehensive analysis of how abnormalities…

计算机视觉与模式识别 · 计算机科学 2026-03-11 Tran Bao Sam , Hung Vu , Dao Trung Kien , Tran Dat Dang , Van Ha Tang , Steven Truong

Graph convolutional neural networks (GCNN) have been successfully applied to many different graph based learning tasks including node and graph classification, matrix completion, and learning of node embeddings. Despite their impressive…

机器学习 · 计算机科学 2019-10-29 Soumyasundar Pal , Florence Regol , Mark Coates

Unsupervised anomaly detection aims to identify anomalous samples from highly complex and unstructured data, which is pervasive in both fundamental research and industrial applications. However, most existing methods neglect the complex…

机器学习 · 计算机科学 2020-10-20 Haoyi Fan , Fengbin Zhang , Ruidong Wang , Liang Xi , Zuoyong Li

Time series graphical models have recently received considerable attention for characterizing (conditional) dependence structures in multivariate time series. In many applications, the multivariate series exhibit variable-partitioned…

统计方法学 · 统计学 2026-04-09 Qin Fang , Xinghao Qiao , Zihan Wang

Gaussian graphical model is one of the powerful tools to analyze conditional independence between two variables for multivariate Gaussian-distributed observations. When the dimension of data is moderate or high, penalized likelihood methods…

统计方法学 · 统计学 2025-01-24 Takahiro Onizuka , Shintaro Hashimoto

Machine learning methods can detect complex relationships between variables, but usually do not exploit domain knowledge. This is a limitation because in many scientific disciplines, such as systems biology, domain knowledge is available in…

人工智能 · 计算机科学 2023-07-31 Bastian Pfeifer , Hubert Baniecki , Anna Saranti , Przemyslaw Biecek , Andreas Holzinger

Omics data, such as transcriptomics, proteomics, and metabolomics, provide critical insights into disease mechanisms and clinical outcomes. However, their high dimensionality, small sample sizes, and intricate biological networks pose major…

机器学习 · 计算机科学 2026-01-22 Tiantian Yang , Yuxuan Wang , Zhenwei Zhou , Ching-Ti Liu

In the modern age of social media and networks, graph representations of real-world phenomena have become an incredibly useful source to mine insights. Often, we are interested in understanding how entities in a graph are interconnected.…

机器学习 · 计算机科学 2021-12-16 Aneesh Komanduri , Justin Zhan