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Computational models that accurately predict the binding affinity of an input protein-chemical pair can accelerate drug discovery studies. These models are trained on available protein-chemical interaction datasets, which may contain…

定量方法 · 定量生物学 2023-01-10 Rıza Özçelik , Alperen Bağ , Berk Atıl , Melih Barsbey , Arzucan Özgür , Elif Özkırımlı

Understanding why a model makes a certain prediction can be as crucial as the prediction's accuracy in many applications. However, the highest accuracy for large modern datasets is often achieved by complex models that even experts struggle…

人工智能 · 计算机科学 2017-11-28 Scott Lundberg , Su-In Lee

Representational similarity analysis (RSA) is a multivariate technique to investigate cortical representations of objects or constructs. While avoiding ill-posed matrix inversions that plague multivariate approaches in the presence of many…

统计方法学 · 统计学 2021-12-03 Roberto Viviani

Pairwise re-ranking models predict which of two documents is more relevant to a query and then aggregate a final ranking from such preferences. This is often more effective than pointwise re-ranking models that directly predict a relevance…

信息检索 · 计算机科学 2022-07-12 Lukas Gienapp , Maik Fröbe , Matthias Hagen , Martin Potthast

We introduce a class of algorithms, termed proximal interacting particle Langevin algorithms (PIPLA), for inference and learning in latent variable models whose joint probability density is non-differentiable. Leveraging proximal Markov…

统计计算 · 统计学 2025-05-30 Paula Cordero Encinar , Francesca R. Crucinio , O. Deniz Akyildiz

Big data is transforming our world, revolutionizing operations and analytics everywhere, from financial engineering to biomedical sciences. The complexity of big data often makes dimension reduction techniques necessary before conducting…

统计方法学 · 统计学 2018-01-08 Jianqing Fan , Qiang Sun , Wen-Xin Zhou , Ziwei Zhu

We introduce a new method for estimating the parameter of the bivariate Clayton copulas within the framework of Algorithmic Inference. The method consists of a variant of the standard boot-strapping procedure for inferring random…

机器学习 · 统计学 2019-10-08 Bruno Apolloni

Sparse principal component analysis (sparse PCA) is a widely used technique for dimensionality reduction in multivariate analysis, addressing two key limitations of standard PCA. First, sparse PCA can be implemented in high-dimensional low…

统计方法学 · 统计学 2025-10-07 Jan O. Bauer

Principal component analysis (PCA) is commonly used in genetics to infer and visualize population structure and admixture between populations. PCA is often interpreted in a way similar to inferred admixture proportions, where it is assumed…

统计方法学 · 统计学 2023-02-10 Jan van Waaij , Song Li , Genís Garcia-Erill , Anders Albrechtsen , Carsten Wiuf

Imbalances in covariates between treatment groups are frequent in observational studies and can lead to biased comparisons. Various adjustment methods can be employed to correct these biases in the context of multi-level treatments ($>$ 2).…

应用统计 · 统计学 2021-06-04 Diop S. Arona , Duchesne Thierry , Cumming Steven , Diop Awa , Talbot Denis

Probabilistic models often have parameters that can be translated, scaled, permuted, or otherwise transformed without changing the model. These symmetries can lead to strong correlation and multimodality in the posterior distribution over…

机器学习 · 统计学 2013-12-20 Robert Nishihara , Thomas Minka , Daniel Tarlow

Principal component analysis (PCA) is a classical dimension reduction method which projects data onto the principal subspace spanned by the leading eigenvectors of the covariance matrix. However, it behaves poorly when the number of…

统计理论 · 数学 2013-05-27 Zongming Ma

Data values in a dataset can be missing or anomalous due to mishandling or human error. Analysing data with missing values can create bias and affect the inferences. Several analysis methods, such as principle components analysis or…

人工智能 · 计算机科学 2022-05-11 Sandeep Hans , Diptikalyan Saha , Aniya Aggarwal

Sparse principal component analysis (SPCA) has emerged as a powerful technique for modern data analysis, providing improved interpretation of low-rank structures by identifying localized spatial structures in the data and disambiguating…

The preferential attachment (PA) model is a popular way of modeling dynamic social networks, such as collaboration networks. Assuming that the PA function takes a parametric form, we propose and study the maximum likelihood estimator of the…

统计理论 · 数学 2022-08-17 Fengnan Gao , Aad van der Vaart

Principal component analysis (PCA) has been widely applied to dimensionality reduction and data pre-processing for different applications in engineering, biology and social science. Classical PCA and its variants seek for linear projections…

机器学习 · 计算机科学 2017-07-11 Xiaojun Chang , Feiping Nie , Yi Yang , Heng Huang

Explainable AI is an emerging field providing solutions for acquiring insights into automated systems' rationale. It has been put on the AI map by suggesting ways to tackle key ethical and societal issues. Existing explanation techniques…

机器学习 · 计算机科学 2022-05-02 Ioannis Mollas , Nick Bassiliades , Grigorios Tsoumakas

Dimension reduction is useful for exploratory data analysis. In many applications, it is of interest to discover variation that is enriched in a "foreground" dataset relative to a "background" dataset. Recently, contrastive principal…

统计方法学 · 统计学 2021-05-04 Didong Li , Andrew Jones , Barbara Engelhardt

Learning Ising or Potts models from data has become an important topic in statistical physics and computational biology, with applications to predictions of structural contacts in proteins and other areas of biological data analysis. The…

生物物理 · 物理学 2018-09-19 Chen-Yi Gao , Hai-Jun Zhou , Erik Aurell

This study proposes a low-complexity interpretable classification system. The proposed system contains three main modules including feature extraction, feature reduction, and classification. All of them are linear. Thanks to the linear…

计算机视觉与模式识别 · 计算机科学 2020-04-15 Tzu-Wei Tseng , Kai-Jiun Yang , C. -C. Jay Kuo , Shang-Ho , Tsai