相关论文: Activity-induced instabilities of brain organoids
Active stresses can cause instabilities in contractile gels and living tissues. Here we describe a generic hydrodynamic theory that treats these systems as a mixture of two phases of varying activity and different mechanical properties. We…
Active-elastic instabilities are common phenomena in the natural world which have the aspect of sudden mechanical morphings. Frequently, the driving force of the instability mechanisms has a chemo-mechanical nature which makes these kind of…
Understanding the mechanics of brain embryogenesis can provide insights on pathologies related to brain development, such as lissencephaly, a genetic disease which cause a reduction of the number of cerebral sulci. Recent experiments on…
The emergence of hydrodynamic bend instabilities in ordered suspensions of active particles is widely observed across diverse living and synthetic systems, and is considered to be governed by dipolar active stresses generated by the…
Tremendous neuroscientific progress has recently been made by mapping brain connectivity, complementing extensive knowledge of task-evoked brain activation patterns. However, despite evidence that they are related, these connectivity and…
Metastable brain dynamics are characterized by abrupt, jump-like modulations so that the neural activity in single trials appears to unfold as a sequence of discrete, quasi-stationary states. Evidence that cortical neural activity unfolds…
One of the defining features of active nematics is that above a critical activity the quiescent state becomes unstable to a distorted, flowing one. We show that spatial variations in activity can fundamentally change the nature of this…
Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs…
Brain organoids recapitulate a number of brain properties, including neuronal diversity. However, do they recapitulate brain structure? Using a hydrodynamic description for cell nuclei as particles interacting initially via an effective,…
The directed motion of active colloids is governed by spatial variations in surface chemistry and interfacial stress, yet these properties remain extremely difficult to measure directly. We introduce a physics-informed neural network…
Living systems are chiral on multiple scales, from constituent biopolymers to large scale morphology, and their active mechanics is both driven by chiral components and serves to generate chiral morphologies. We describe the mechanics of…
Models for fluid deformable surfaces provide valid theories to describe the dynamics of thin fluidic sheets of soft materials. To use such models in morphogenesis and development requires to incorporate active forces. We consider active…
Microswimmers and active colloids often move in confined systems, including those involving interfaces. Such interfaces, especially at the microscale, may deform in response to the stresses of the flow created by the active particle. We…
The Ogden model is often considered as a standard model in the literature for application to the deformation of brain tissue. Here we show that, in some of those applications, the use of the Ogden model leads to non-convexity of the…
We consider two minimal models of active fluid droplets that exhibit complex dynamics including steady motion, deformation, rotation and oscillating motion. First we consider a droplet with a concentration of active contractile matter…
A new hydrodynamic mechanism is proposed for the ion beam induced surface patterning on solid surfaces. Unlike the standard mechanisms based on the ion beam impact generated erosion and mass redistribution at the free surface (proposed by…
Active stresses in biological cells and tissues drive many developmental processes. However, increasing experimental evidence suggests that additional mechanical interactions with surrounding material can play a crucial role in guiding…
Active contributions to fluctuations are a direct consequence of metabolic energy consumption in living cells. Such metabolic processes continuously create active forces, which deform the membrane to control motility, proliferation as well…
The brain is a non-equilibrium system whose dynamics change in different brain states, such as wakefulness and deep sleep. Thermodynamics provides the tools for revealing these non-equilibrium dynamics. We used violations of the…
During the early-stages of embryo development, morphogenesis--- the emergence of shape and form in living organisms--- is almost exclusively associated with monolayers of tightly bound epithelial cells. To understand how such tissues change…