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Accurate prediction of clinical scores is critical for early detection and prognosis of Alzheimers disease (AD). While existing approaches primarily focus on forecasting the ADAS-Cog global score, they often overlook the predictive value of…

The transition from mild cognitive impairment (MCI) to Alzheimer's disease (AD) is of great interest to clinical researchers. This phenomenon also serves as a valuable data source for quantitative methodological researchers developing new…

应用统计 · 统计学 2020-12-02 Zihuan Liu , Tapabrate Maiti , Andrew R. Bender

The systemic, metabolic, lifestyle factors have established associations with Alzheimer's Disease (AD) through epidemiologic and AD-specific biomarker studies. Whether colored fundus photography (CFP) contains retinal structural signatures…

计算机视觉与模式识别 · 计算机科学 2026-05-04 Seowung Leem , Yunchao Yang , Adam J. Woods , Ruogu Fang

Alzheimer's disease is a progressive, neurodegenerative disorder that causes memory loss and cognitive decline. While there has been extensive research in applying deep learning models to Alzheimer's prediction tasks, these models remain…

计算机视觉与模式识别 · 计算机科学 2025-09-15 Emily Kaczmarek , Justin Szeto , Brennan Nichyporuk , Tal Arbel

The ability to predict the future trajectory of a patient is a key step toward the development of therapeutics for complex diseases such as Alzheimer's disease (AD). However, most machine learning approaches developed for prediction of…

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer\{'}s disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

机器学习 · 计算机科学 2016-11-15 Ehsan Hosseini-Asl , Robert Keynto , Ayman El-Baz

Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming traditional statistical techniques. However, to establish ML as a reliable tool in clinical practice, adherence to best practices regarding data…

图像与视频处理 · 电气工程与系统科学 2023-09-15 Rosanna Turrisi , Alessandro Verri , Annalisa Barla

Early and accessible detection of Alzheimer's disease (AD) remains a major challenge, as current diagnostic methods often rely on costly and invasive biomarkers. Speech and language analysis has emerged as a promising non-invasive and…

音频与语音处理 · 电气工程与系统科学 2026-03-06 Franziska Braun , Christopher Witzl , Florian Hönig , Elmar Nöth , Tobias Bocklet , Korbinian Riedhammer

Alzheimer's disease is a degenerative brain disease. Being the primary cause of Dementia in adults and progressively destroys brain memory. Though Alzheimer's disease does not have a cure currently, diagnosing it at an earlier stage will…

机器学习 · 计算机科学 2023-02-17 Shrish Pellakur , Nelly Elsayed , Zag ElSayed , Murat Ozer

Early detection is crucial to prevent the progression of Alzheimer's disease (AD). Thus, specialists can begin preventive treatment as soon as possible. They demand fast and precise assessment in the diagnosis of AD in the earliest and…

Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related…

机器学习 · 计算机科学 2016-07-05 Ehsan Hosseini-Asl , Georgy Gimel'farb , Ayman El-Baz

As shown in computer vision, the power of deep learning lies in automatically learning relevant and powerful features for any perdition task, which is made possible through end-to-end architectures. However, deep learning approaches applied…

计算机视觉与模式识别 · 计算机科学 2018-10-02 Soheil Esmaeilzadeh , Dimitrios Ioannis Belivanis , Kilian M. Pohl , Ehsan Adeli

Speech is usually used for constructing an automatic Alzheimer's dementia (AD) detection system, as the acoustic and linguistic abilities show a decline in people living with AD at the early stages. However, speech includes not only…

音频与语音处理 · 电气工程与系统科学 2024-10-11 Yilin Pan , Yanpei Shi , Yijia Zhang , Mingyu Lu

In diagnosing challenging conditions such as Alzheimer's disease (AD), imaging is an important reference. Non-imaging patient data such as patient information, genetic data, medication information, cognitive and memory tests also play a…

机器学习 · 计算机科学 2023-06-01 Yingjie Feng , Jun Wang , Xianfeng Gu , Xiaoyin Xu , Min Zhang

Alzheimer's disease (AD) is a progressive brain disorder that causes memory and functional impairments. The advances in machine learning and publicly available medical datasets initiated multiple studies in AD diagnosis. In this work, we…

图像与视频处理 · 电气工程与系统科学 2021-07-20 Aidana Massalimova , Huseyin Atakan Varol

A novel framework is proposed for handling the complex task of modelling and analysis of longitudinal, multivariate, heterogeneous clinical data. This method uses temporal abstraction to convert the data into a more appropriate form for…

机器学习 · 计算机科学 2025-05-09 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

We describe a new method to automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on multidimensional classification of hippocampal shape features. This…

To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions. To help uncover the relationships between brain circuits and cognitive…

Cognitive impairment detection through spontaneous speech is a promising avenue for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), where timely intervention can significantly improve patient outcomes. The…

声音 · 计算机科学 2025-02-19 Yifan Gao , Long Guo , Hong Liu

The detection of Alzheimer's disease (AD) from spontaneous speech has attracted increasing attention while the sparsity of training data remains an important issue. This paper handles the issue by knowledge transfer, specifically from both…

计算与语言 · 计算机科学 2024-04-02 Ziyun Cui , Wen Wu , Wei-Qiang Zhang , Ji Wu , Chao Zhang