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Lung cancer is the leading cause of cancer-related mortality worldwide. Lung cancer screening (LCS) using annual low-dose computed tomography (CT) scanning has been proven to significantly reduce lung cancer mortality by detecting cancerous…

Prognostic models in survival analysis are aimed at understanding the relationship between patients' covariates and the distribution of survival time. Traditionally, semi-parametric models, such as the Cox model, have been assumed. These…

机器学习 · 统计学 2020-11-06 Denise Rava , Jelena Bradic

Lung cancer is a major cause of cancer-related deaths, and early diagnosis and treatment are crucial for improving patients' survival outcomes. In this paper, we propose to employ convolutional neural networks to model the non-linear…

图像与视频处理 · 电气工程与系统科学 2024-08-20 Xiawei Wang , James Sharpnack , Thomas C. M. Lee

One of the main challenges for broad adoption of deep learning based models such as convolutional neural networks (CNN), is the lack of understanding of their decisions. In many applications, a simpler, less capable model that can be easily…

计算机视觉与模式识别 · 计算机科学 2018-02-08 Devinder Kumar , Vlado Menkovski , Graham W. Taylor , Alexander Wong

The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In…

机器学习 · 计算机科学 2017-01-27 Zhengping Che , Yu Cheng , Zhaonan Sun , Yan Liu

With the long-term rapid increase in incidences of colorectal cancer (CRC), there is an urgent clinical need to improve risk stratification. The conventional pathology report is usually limited to only a few histopathological features.…

图像与视频处理 · 电气工程与系统科学 2020-07-08 Christian Abbet , Inti Zlobec , Behzad Bozorgtabar , Jean-Philippe Thiran

Accurate survival prediction is crucial for development of precision cancer medicine, creating the need for new sources of prognostic information. Recently, there has been significant interest in exploiting routinely collected clinical and…

机器学习 · 计算机科学 2021-03-23 Sejin Kim , Michal Kazmierski , Benjamin Haibe-Kains

An every increasing number of clinical trials features a time-to-event outcome and records non-tabular patient data, such as magnetic resonance imaging or text data in the form of electronic health records. Recently, several neural-network…

机器学习 · 计算机科学 2022-10-24 Gabriele Campanella , Lucas Kook , Ida Häggström , Torsten Hothorn , Thomas J. Fuchs

Understanding how deep learning models predict oncology patient risk can provide critical insights into disease progression, support clinical decision-making, and pave the way for trustworthy and data-driven precision medicine. Building on…

计算机视觉与模式识别 · 计算机科学 2024-11-13 Marvin Sextro , Gabriel Dernbach , Kai Standvoss , Simon Schallenberg , Frederick Klauschen , Klaus-Robert Müller , Maximilian Alber , Lukas Ruff

Deep learning motivated by convolutional neural networks has been highly successful in a range of medical imaging problems like image classification, image segmentation, image synthesis etc. However for validation and interpretability, not…

图像与视频处理 · 电气工程与系统科学 2024-08-19 Abhinav Sagar

Accurate prognostication and risk estimation are essential for guiding clinical decision-making and optimizing patient management. While radiologist-assessed features from CT scans provide valuable indicators of disease severity and…

Prognostication for lung cancer, a leading cause of mortality, remains a complex task, as it needs to quantify the associations of risk factors and health events spanning a patient's entire life. One challenge is that an individual's…

机器学习 · 统计学 2025-08-28 Stephen Salerno , Yi Li

Survival analysis plays a crucial role in many healthcare decisions, where the risk prediction for the events of interest can support an informative outlook for a patient's medical journey. Given the existence of data censoring, an…

机器学习 · 计算机科学 2023-09-29 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Bin Liu , Mei Liu , Zijun Yao

The COVID-19 pandemic has had a considerable impact on day-to-day life. Tackling the disease by providing the necessary resources to the affected is of paramount importance. However, estimation of the required resources is not a trivial…

图像与视频处理 · 电气工程与系统科学 2022-05-11 Sai Vidyaranya Nuthalapati , Marcela Vizcaychipi , Pallav Shah , Piotr Chudzik , Chee Hau Leow , Paria Yousefi , Ahmed Selim , Keiran Tait , Ben Irving

Survival models are used in various fields, such as the development of cancer treatment protocols. Although many statistical and machine learning models have been proposed to achieve accurate survival predictions, little attention has been…

机器学习 · 计算机科学 2020-03-26 Hrushikesh Loya , Pranav Poduval , Deepak Anand , Neeraj Kumar , Amit Sethi

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data.…

计算机视觉与模式识别 · 计算机科学 2024-04-05 Paschalis Bizopoulos , Dimitrios Koutsouris

Deep learning models for survival analysis have gained significant attention in the literature, but they suffer from severe performance deficits when the dataset contains many irrelevant features. We give empirical evidence for this problem…

机器学习 · 计算机科学 2019-03-08 Carl Rietschel , Jinsung Yoon , Mihaela van der Schaar

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, yet early risk detection is often limited by available diagnostics. Carotid ultrasound, a non-invasive and widely accessible modality, encodes rich structural…

The abundance of modern health data provides many opportunities for the use of machine learning techniques to build better statistical models to improve clinical decision making. Predicting time-to-event distributions, also known as…

机器学习 · 统计学 2020-12-15 Zidi Xiu , Chenyang Tao , Benjamin A. Goldstein , Ricardo Henao

Digital mammography is essential to breast cancer detection, and deep learning offers promising tools for faster and more accurate mammogram analysis. In radiology and other high-stakes environments, uninterpretable ("black box") deep…

计算机视觉与模式识别 · 计算机科学 2024-06-11 Julia Yang , Alina Jade Barnett , Jon Donnelly , Satvik Kishore , Jerry Fang , Fides Regina Schwartz , Chaofan Chen , Joseph Y. Lo , Cynthia Rudin