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This paper provides a link between causal inference and machine learning techniques - specifically, Classification and Regression Trees (CART) - in observational studies where the receipt of the treatment is not randomized, but the…

机器学习 · 计算机科学 2019-05-23 Falco J. Bargagli-Stoffi , Giorgio Gnecco

This paper generalizes the changes-in-changes (CIC) model to handle discrete treatments with more than two categories, extending the binary case of Athey and Imbens (2006). While the original CIC model is well-suited for binary treatments,…

计量经济学 · 经济学 2024-11-05 Onil Boussim

One of the most significant challenges in Conditional Average Treatment Effect (CATE) estimation is the statistical discrepancy between distinct treatment groups. To address this issue, we propose a model-agnostic data augmentation method…

机器学习 · 计算机科学 2025-06-17 Ahmed Aloui , Juncheng Dong , Cat P. Le , Vahid Tarokh

Quantifying the causal effects of continuous exposures on outcomes of interest is critical for social, economic, health, and medical research. However, most existing software packages focus on binary exposures. We develop the CausalGPS R…

统计计算 · 统计学 2023-10-03 Naeem Khoshnevis , Xiao Wu , Danielle Braun

In observational studies, the assumption of sufficient overlap (positivity) is fundamental for the identification and estimation of causal effects. Failing to account for this assumption yields inaccurate and potentially infeasible…

统计方法学 · 统计学 2025-04-07 Jaehyuk Jang , Suehyun Kim , Kwonsang Lee

Treatment effect estimation is essential for informed decision-making in many fields such as healthcare, economics, and public policy. While flexible machine learning models have been widely applied for estimating heterogeneous treatment…

机器学习 · 计算机科学 2025-09-29 Pascal Memmesheimer , Vincent Heuveline , Jürgen Hesser

Missing data is a major challenge in clinical research. In electronic medical records, often a large fraction of the values in laboratory tests and vital signs are missing. The missingness can lead to biased estimates and limit our ability…

机器学习 · 计算机科学 2023-04-18 Omer Noy , Ron Shamir

The association between multidimensional exposure patterns and outcomes is commonly investigated by first applying cluster analysis algorithms to derive patterns and then estimating the associations. However, errors in the underlying…

统计方法学 · 统计学 2023-05-31 Timm Intemann , Iris Pigeot

Medical advances have increased cancer survival rates and the possibility of finding a cure. Hence, it is crucial to evaluate the impact of treatments both in terms of cure and prolongation of survival. To achieve this, we may use a Cox…

统计方法学 · 统计学 2024-12-31 Marta Cipriani , Marta Fiocco , Marco Alfò , Maria Quelhas , Eni Musta

The increased prevalence of observational data and the need to integrate information from multiple sources are critical challenges in contemporary data analysis. Record linkage is a widely used tool for combining datasets in the absence of…

统计方法学 · 统计学 2025-12-17 Martin Slawski

The foremost challenge to causal inference with real-world data is to handle the imbalance in the covariates with respect to different treatment options, caused by treatment selection bias. To address this issue, recent literature has…

机器学习 · 统计学 2022-02-23 Zhixuan Chu , Stephen Rathbun , Sheng Li

Interpretability and transparency are essential for incorporating causal effect models from observational data into policy decision-making. They can provide trust for the model in the absence of ground truth labels to evaluate the accuracy…

统计方法学 · 统计学 2024-02-01 Lucile Ter-Minassian , Liran Szlak , Ehud Karavani , Chris Holmes , Yishai Shimoni

We propose Causal Interaction Trees for identifying subgroups of participants that have enhanced treatment effects using observational data. We extend the Classification and Regression Tree algorithm by using splitting criteria that focus…

统计方法学 · 统计学 2021-12-08 Jiabei Yang , Issa J. Dahabreh , Jon A. Steingrimsson

Generating probabilistic forecasts of potential outcomes and individual treatment effects (ITE) is essential for risk-aware decision-making in domains such as healthcare, policy, marketing, and finance. We propose two novel methods: the…

机器学习 · 计算机科学 2025-09-24 Jef Jonkers , Jarne Verhaeghe , Glenn Van Wallendael , Luc Duchateau , Sofie Van Hoecke

Analysis of longitudinal randomised controlled trials is frequently complicated because patients deviate from the protocol. Where such deviations are relevant for the estimand, we are typically required to make an untestable assumption…

统计方法学 · 统计学 2018-05-16 Suzie Cro , James R Carpenter , Michael G Kenward

The interventional effects approach to causal mediation analysis is increasingly common in epidemiologic research, given its potential to address policy-relevant questions about hypothetical mediator interventions. Multiple imputation (MI)…

Despite the popularity of Vision Transformers (ViTs) and eXplainable AI (XAI), only a few explanation methods have been designed specially for ViTs thus far. They mostly use attention weights of the [CLS] token on patch embeddings and often…

计算机视觉与模式识别 · 计算机科学 2023-06-12 Weiyan Xie , Xiao-Hui Li , Caleb Chen Cao , Nevin L. Zhang

Randomized trials typically estimate average relative treatment effects, but decisions on the benefit of a treatment are possibly better informed by more individualized predictions of the absolute treatment effect. In case of a binary…

统计方法学 · 统计学 2021-08-20 J Hoogland , J IntHout , M Belias , MM Rovers , RD Riley , FE Harrell , KGM Moons , TPA Debray , JB Reitsma

We develop methodology for causal inference in observational studies when using propensity score subclassification on data constructed with probabilistic record linkage techniques. We focus on scenarios where covariates and binary treatment…

统计方法学 · 统计学 2018-04-03 Joan Heck Wortman , Jerome P. Reiter

Causal inference concerns not only the average effect of the treatment on the outcome but also the underlying mechanism through an intermediate variable of interest. Principal stratification characterizes such a mechanism by targeting…

统计方法学 · 统计学 2022-03-29 Zhichao Jiang , Shu Yang , Peng Ding