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Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently very little brain disorder…

神经元与认知 · 定量生物学 2021-02-08 Beatriz E. P. Mizusaki , Cian O'Donnell

We introduce Neural Optimal Design of Experiments, a learning-based framework for optimal experimental design in inverse problems that avoids classical bilevel optimization and indirect sparsity regularization. NODE jointly trains a neural…

机器学习 · 计算机科学 2026-01-08 John E. Darges , Babak Maboudi Afkham , Matthias Chung

Neural networks have been criticized for their lack of easy interpretation, which undermines confidence in their use for important applications. Here, we introduce a novel technique, interpreting a trained neural network by investigating…

机器学习 · 计算机科学 2019-03-22 Roozbeh Yousefzadeh , Dianne P. O'Leary

Function and dysfunctions of neural systems are tied to the temporal evolution of neural states. The current limitations in showing their causal role stem largely from the absence of tools capable of probing the brain's internal state in…

No man is an island, as individuals interact and influence one another daily in our society. When social influence takes place in experiments on a population of interconnected individuals, the treatment on a unit may affect the outcomes of…

统计方法学 · 统计学 2017-08-30 Edward K. Kao

The brain is a highly complex organ consisting of a myriad of subsystems that flexibly interact and adapt over time and context to enable perception, cognition, and behavior. Understanding the multi-scale nature of the brain, i.e., how…

神经元与认知 · 定量生物学 2025-01-17 Adam S. Charles

Sparse coding is a basic task in many fields including signal processing, neuroscience and machine learning where the goal is to learn a basis that enables a sparse representation of a given set of data, if one exists. Its standard…

机器学习 · 计算机科学 2015-03-04 Sanjeev Arora , Rong Ge , Tengyu Ma , Ankur Moitra

Estimating the effects of interventions in networks is complicated when the units are interacting, such that the outcomes for one unit may depend on the treatment assignment and behavior of many or all other units (i.e., there is…

统计方法学 · 统计学 2014-08-15 Dean Eckles , Brian Karrer , Johan Ugander

The study of mechanistic interpretability aims to reverse-engineer a model to explain its behaviors. While recent studies have focused on the static mechanism of a certain behavior, the learning dynamics inside a model remain to be…

机器学习 · 计算机科学 2025-09-24 Yueyan Li , Wenhao Gao , Caixia Yuan , Xiaojie Wang

Ising machines are a form of quantum-inspired processing-in-memory computer which has shown great promise for overcoming the limitations of traditional computing paradigms while operating at a fraction of the energy use. The process of…

最优化与控制 · 数学 2025-07-18 Isaac K. Martin , Andrew G. Moore , John T. Daly , Jess J. Meyer , Teresa M. Ranadive

Neuroscience research is undergoing a minor revolution. Recent advances in machine learning and artificial intelligence (AI) research have opened up new ways of thinking about neural computation. Many researchers are excited by the…

神经元与认知 · 定量生物学 2020-04-20 Andrew Saxe , Stephanie Nelli , Christopher Summerfield

Reversible simulation of irreversible algorithms is analyzed in the stylized form of a `reversible' pebble game. While such simulations incur little overhead in additional computation time, they use a large amount of additional memory space…

量子物理 · 物理学 2009-10-30 Ming Li , John Tromp , Paul Vitanyi

Modelling persuasion strategies as predictors of task outcome has several real-world applications and has received considerable attention from the computational linguistics community. However, previous research has failed to account for the…

Building machines that learn and think like humans is essential not only for cognitive science, but also for computational neuroscience, whose ultimate goal is to understand how cognition is implemented in biological brains. A new cognitive…

人工智能 · 计算机科学 2017-11-15 Nikolaus Kriegeskorte , Robert M. Mok

Inverse optimization describes a process that is the "reverse" of traditional mathematical optimization. Unlike traditional optimization, which seeks to compute optimal decisions given an objective and constraints, inverse optimization…

最优化与控制 · 数学 2022-07-28 Timothy C. Y. Chan , Rafid Mahmood , Ian Yihang Zhu

Contemporary machine learning optimizes for predictive accuracy, yet systems that achieve state of the art performance remain causally opaque: their internal representations provide no principled handle for intervention. We can retrain such…

人工智能 · 计算机科学 2025-10-28 Marcus Thomas

We introduce a new programming language and its categorical semantics in order to design and implement neural networks within the framework of algebraic effects and handlers for arrows. Our language enables us to construct neural networks…

编程语言 · 计算机科学 2026-02-23 Takahiro Sanada , Keisuke Hoshino , Kenshin Hirai , Shin-ya Katsumata

Computation models such as circuits describe sequences of computation steps that are carried out one after the other. In other words, algorithm design is traditionally subject to the restriction imposed by a fixed causal order. We address a…

量子物理 · 物理学 2017-07-04 Ämin Baumeler , Stefan Wolf

The paper introduces RPSE, Reification as a Paradigm of Software Engineering, and enumerates the most important theoretical and practical problems of the development and application of this paradigm. Main thesis: Software engineering is the…

软件工程 · 计算机科学 2018-10-05 Viktor Sirotin

This paper describes some biologically-inspired processes that could be used to build the sort of networks that we associate with the human brain. New to this paper, a 'refined' neuron will be proposed. This is a group of neurons that by…

人工智能 · 计算机科学 2018-02-06 Kieran Greer