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When making treatment selection decisions, it is essential to include a causal effect estimation analysis to compare potential outcomes under different treatments or controls, assisting in optimal selection. However, merely estimating…

机器学习 · 统计学 2024-10-08 Sherly Alfonso-Sánchez , Kristina P. Sendova , Cristián Bravo

We examine study designs for extending (generalizing or transporting) causal inferences from a randomized trial to a target population. Specifically, we consider nested trial designs, where randomized individuals are nested within a sample…

Causal effect estimation from observational data is a crucial but challenging task. Currently, only a limited number of data-driven causal effect estimation methods are available. These methods either provide only a bound estimation of the…

统计方法学 · 统计学 2020-11-10 Debo Cheng , Jiuyong Li , Lin Liu , Kui Yu , Thuc Duy Lee , Jixue Liu

Many applications of causal inference require using treatment effects estimated on a study population to make decisions in a separate target population. We consider the challenging setting where there are covariates that are observed in the…

机器学习 · 计算机科学 2024-10-22 Khurram Yamin , Vibhhu Sharma , Ed Kennedy , Bryan Wilder

This paper combines causal mediation analysis with double machine learning to control for observed confounders in a data-driven way under a selection-on-observables assumption in a high-dimensional setting. We consider the average indirect…

计量经济学 · 经济学 2021-02-17 Helmut Farbmacher , Martin Huber , Lukáš Lafférs , Henrika Langen , Martin Spindler

Many causal models of interest in epidemiology involve longitudinal exposures, confounders and mediators. However, repeated measurements are not always available or used in practice, leading analysts to overlook the time-varying nature of…

统计方法学 · 统计学 2023-02-21 Lola Etievant , Vivian Viallon

Conditioning on some set of confounders that causally affect both treatment and outcome variables can be sufficient for eliminating bias introduced by all such confounders when estimating causal effect of the treatment on the outcome from…

统计方法学 · 统计学 2018-04-24 Priyantha Wijayatunga

We introduce a framework for estimating causal effects of binary and continuous treatments in high dimensions. We show how posterior distributions of treatment and outcome models can be used together with doubly robust estimators. We…

统计方法学 · 统计学 2020-10-06 Joseph Antonelli , Georgia Papadogeorgou , Francesca Dominici

Non-linear mixed effects modeling and simulation (NLME M&S) is evaluated to be used for standardization with longitudinal data in presence of confounders. Standardization is a well-known method in causal inference to correct for confounding…

统计方法学 · 统计学 2024-05-01 Christian Bartels , Martina Scauda , Neva Coello , Thomas Dumortier , Bjoern Bornkamp , Giusi Moffa

An essential goal of program evaluation and scientific research is the investigation of causal mechanisms. Over the past several decades, causal mediation analysis has been used in medical and social sciences to decompose the treatment…

统计方法学 · 统计学 2016-01-15 K. C. G. Chan , K. Imai , S. C. P. Yam , Z. Zhang

The era of big data has witnessed an increasing availability of multiple data sources for statistical analyses. We consider estimation of causal effects combining big main data with unmeasured confounders and smaller validation data with…

统计方法学 · 统计学 2021-08-24 Shu Yang , Peng Ding

We describe a design-based framework for drawing causal inference in general randomized experiments. Causal effects are defined as linear functionals evaluated at unit-level potential outcome functions. Assumptions about the potential…

统计方法学 · 统计学 2025-08-15 Christopher Harshaw , Fredrik Sävje , Yitan Wang

Cluster-randomized trials (CRTs) are widely used to evaluate group-level interventions and increasingly collect multiple outcomes capturing complementary dimensions of benefit and risk. Investigators often seek a single global summary of…

统计方法学 · 统计学 2026-01-22 Xinyuan Chen , Fan Li

We consider methods for causal inference in randomized trials nested within cohorts of trial-eligible individuals, including those who are not randomized. We show how baseline covariate data from the entire cohort, and treatment and outcome…

统计方法学 · 统计学 2019-10-30 Issa Dahabreh , Sarah Robertson , Eric Tchetgen Tchetgen , Elizabeth Stuart , Miguel Hernan

Over the past few decades, statistical methods for causal inference have made impressive strides, enabling progress across a range of scientific fields. However, much of this methodological development has been confined to individual…

统计方法学 · 统计学 2025-09-30 Wenqi Shi , José R. Zubizarreta

Drawing causal conclusions from observational data requires making assumptions about the true data-generating process. Causal inference research typically considers low-dimensional data, such as categorical or numerical fields in structured…

计算与语言 · 计算机科学 2021-02-11 Zach Wood-Doughty , Ilya Shpitser , Mark Dredze

Modern medical research demands specialized causal inference methods evaluating complex continuous-time dynamic treatment regimens using observational data. For instance, obtaining the causal effects of intravenous administration, a…

统计方法学 · 统计学 2026-04-02 Haiyan Zhu , Yingchun Zhou

I argue that regularizing terms in standard regression methods not only help against overfitting finite data, but sometimes also yield better causal models in the infinite sample regime. I first consider a multi-dimensional variable…

机器学习 · 统计学 2019-07-01 Dominik Janzing

Bipartite experiments arise in various fields, in which the treatments are randomized over one set of units, while the outcomes are measured over another separate set of units. However, existing methods often rely on strong model…

统计方法学 · 统计学 2025-04-16 Sizhu Lu , Lei Shi , Yue Fang , Wenxin Zhang , Peng Ding

Predicting the effect of interventions with many possible variations, e.g., therapeutic content that affects mental health outcomes or an earnings call transcript that drives movement in share price, is useful across several domains.…

机器学习 · 计算机科学 2026-05-27 Nikita Dhawan , Arnav Paruthi , Andrew Kim , Lovedeep Gondara , Jekaterina Novikova , Chris J. Maddison